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Abstract This work assesses the impacts of aggressive driving behavior on pollutants emissions and energy consumption at a city level. Furthermore, it performs an economic analysis considering the potential avoided emissions and fuel savings and discusses potential policy measures to address this topic. The results showed that aggressive driving significantly impacts energy consumption and emissions, with energy consumption increasing by more than ∼200% and emissions by 330% for aggressive driving compared to non-aggressive driving (in MJ/km and in g/km, respectively). This increment was found to be even higher for diesel vehicles than for gasoline vehicles. On the contrary, gasoline vehicles showed higher percentages of increase for most emissions (CO, NOx and NO). Results also revealed that aggressive driving impacts are higher for local streets when examining the city level. Moreover, the economic analysis showed that significant cost reductions may be achieved by avoiding aggressive driving, reaching up to 52.5 k€ on a daily basis. In conclusion, this study is of particular relevance to policy makers and urban planners, enabling to obtain a comprehensive overview of the impacts of aggressive driving behaviors at a city level and providing new insights to perform further developments and to assess the feasibility of the implementation of policy measures.

Activity pacing (AP) is a concept that is central to many chronic pain theories and treatments, yet there remains confusion regarding its definition and effects.To review the current knowledge concerning AP and integrate this knowledge in a manner that allows for a clear definition and useful directions for future research.A narrative review of the major theoretical approaches to AP and of the empirical evidence regarding the effects of AP interventions, followed by an integrative discussion.The concept of AP is derived from 2 main traditions: operant and energy conservation. Although there are common elements across these traditions, significant conceptual and practical differences exist, which has led to confusion. Little empirical evidence exists concerning the efficacy of AP as a treatment for chronic pain.Future research on AP should be based on a clear theoretical foundation, consider the context in which the AP behavior occurs and the type of pacing problem ("underactivity" vs. "overactivity"), and should examine the impact of AP treatment on multiple clinical outcomes. We provide a provisional definition of AP and specific recommendations that we believe will move the field forward.

Systemic delivery of therapeutic agents remains ineffective against diffuse intrinsic pontine glioma (DIPG), possibly due to an intact blood-brain-barrier (BBB) and to dose-limiting toxicity of systemic chemotherapeutic agents. Convection-enhanced delivery (CED) into the brainstem may provide an effective local delivery alternative for DIPG patients.The aim of this study is to develop a method to perform CED into the murine brainstem and to test this method using the chemotherapeutic agent carmustine (BiCNU). To this end, a newly designed murine CED catheter was tested in vitro and in vivo. After determination of safety and distribution, mice bearing VUMC-DIPG-3 and E98FM-DIPG brainstem tumors were treated with carmustine dissolved in DW 5% or carmustine dissolved in 10% ethanol.Our results show that CED into the murine brainstem is feasible and well tolerated by mice with and without brainstem tumors. CED of carmustine dissolved in 5% DW increased median survival of mice with VUMC-DIPG-3 and E98FM-DIPG tumors with 35% and 25% respectively. Dissolving carmustine in 10% ethanol further improved survival to 45% in mice with E98FM-DIPG tumors.Since genetically engineered and primary DIPG models are currently only available in mice, murine CED studies have clear advantages over CED studies in other animals.CED in the murine brainstem can be performed safely, is well tolerated and can be used to study efficacy of chemotherapeutic agents orthotopically. These results set the foundation for more CED studies in murine DIPG models.

Alternative fuels and energy vectors are becoming increasingly important in terms of technical, geopolitical, economic, and environmental aspects. In particular, gaseous fuels and vectors, such as fossil or synthetic natural gas (NG) blended with hydrogen, commonly help provide optimal strategies to reduce global and toxic emissions of internal combustion engines, owing to their adaptability, anti-knock capacity, lower toxicity of pollutants, reduced CO2 emissions, and costeffectiveness. However, diesel engines still represent the reference category among internal combustion engines in terms of maximum thermodynamic efficiency. The possibility offered by dual-fuel (DF) systems to combine the efficiency and performance of diesel engines with the environmental advantages of gaseous fuels has been the subject of extensive investigations. However, the simple replacement of diesel fuel with gaseous fuel does not allow for optimising the engine performance, owing to the high percentage of unburned gaseous fuel, which compromises the potential reduction of CO2; therefore, more complex combustion strategies should be realised. In this study, with the aim of improving the DF combustion process, an experimental investigation was performed to analyse low-temperature combustion (LTC), using NG and two enriched hydrogen-compressed NG blends as primary fuels. The LTC mode was activated by means of a very early advanced pilot injection and carried out in two close steps. The double pilot injection was used to control the energy release rate in the first combustion stage, thereby minimizing the increase of the rate of pressure and allowing the extension of the operation range under LTC. The experimental activity was also focused on analysing the particle emissions, as it is well known that these emissions, together with those of nitrogen oxide, constitute the main pollutants resulting from diesel fuel combustion. The results demonstrated the potential to reduce the unburned fuel, NOx, and particle emissions simultaneously, while maintaining equivalent CO2 emissions to a diesel-only engine. Both the timing and pressure of the pilot injection proved to be critical parameters for optimising the emissions and performance

Despite the well-established finding from questionnaire studies that positive expectancies are associated with drinking behavior, there is comparatively little known about the mechanisms through which they may affect drinking behavior. Incentive motivation models suggest that alcohol itself may alter the value of the expected outcomes of drinking. The current study was designed to examine the influence of low-dose alcohol on the activation of alcohol outcome expectancy value.Forty-eight hazardous drinkers (34 men) between the ages of 21 and 35 years were recruited from advertisements in local newspapers for a social drinking study. Participants, whose most frequently consumed beverage was beer, were administered a dose of either alcoholic (8.5%) beer, based on gender and weight to reach a blood alcohol concentration of 40 mg/dl, or an equivalent volume of placebo beer. Following an absorption phase, a computerized evaluative priming task was completed in which participants made a series of judgments about the value of positive and negative outcomes following either alcohol or neutral word primes.Those who consumed alcohol made faster evaluative responses to positive relative to negative outcomes, compared with individuals who consumed the placebo beverage.These findings suggest that moderate doses of alcohol may influence the incentive value of positive relative to negative outcome expectancies. It is suggested that these processes may play a role in patterns of hazardous alcohol use.

Stories play an exceptionally important role in how people assign value to a place. Taken together, all those stories essentially give a place an identity. The aim of placemaking is to ensure that the people using a place can appreciate that place. Placemaking approaches are focussed on strategic interventions in a place and aimed at changing the meaning and value of that place for local people, thus creating a qualitative place for enhanced storytelling. Using greenery is a common approach in place-making. Urban greenery has gone through a process of emancipation in the past 15 years. This emancipation has led to awareness that urban greenery is about more than just ecology and biodiversity, but also has social and economic consequences for a city’s fortunes. It is clear that green spaces do not stand alone: they are part of a complex urban system, and the use of green spaces in this complex system has immediate repercussions for how the city functions. With the changing role of green spaces within cities, the need to manage these spaces is emphasized. In this sense, the place-making approach, along with the storytelling approach could provide valuable insight on the planning and management of green spaces within the urban environment, with the aim to enhance quality of life by means of the social connection between people, the users of the space, and the qualitative place provided. This research illustrated that green space managers would need more social and organizational skills to manage modern urban green spaces in an attempt to create qualitative, usable spaces for citizens, spaces that are built upon stories and spaces that would further enable future stories of citizen life. The Story Behind the Place: Creating Urban Spaces That Enhance Quality of Life (PDF Download Available). Available from: https://www.researchgate.net/publication/271918395_The_Story_Behind_the_Place_Creating_Urban_Spaces_That_Enhance_Quality_of_Life [accessed Dec 21, 2015].

In themediumtolongterm,lowfossilfuelavailabilitywillmakeitnecessarytofindalternatives.Mass productionofbiofuelswillnotbeapracticalsolutionbecauseitrequiresstrongcompetitionforland that isusedforgrowingfood.Therefore,itwillbenecessarytorevisetheframeoftransportation energy sources.Thenumberofpurelight-andheavy-dutyelectricvehiclescouldincreaseinurban areas.Instead,itwillbehardtofindaviablealternativetotheinternalcombustionengineforextra- urban transportvehicles,thereforealternativesyntheticfuelscouldbeusedtocompensateforfossil fuel depletion.Asidefromasmallshareobtainablefrombiomass,mostsyntheticfuelsareexpectedto be obtainedfromcoal.Amongthese,syntheticnaturalgasrepresentsaverygoodsolution.Infact, syntheticnaturalgaswillbeadvantageouswithrespecttohydrogen,whoseon-boardstoragewillbean unsolvedprobleminthemediumterm,andwithrespecttosyntheticliquidfuels,whichrequiremore energy intheproductionphase.Moreover,thecarboncontentofliquidfuels,whichishigherthanthat of gaseousfuels,willberesponsibleforhigherCO2 emissionsfromvehicles.Currently,naturalgashas poor diffusioninthetransportsector,andthispaperhighlightsthemotivationsforfavouringapolicy aimedatincreasingtheshareofgaseousfuel-poweredvehicles.Inadditiontothelowenvironmental impact,syntheticnaturalgasalsooffersthepossibilityofoptimisingtheutilisationoffutureresources

Biodegradation rates of benzoate and related aromatic compounds, 3-nitrobenzoate, 4-chlorobenzoate, 4-chlorophenol, and 2,4-dichlorophenol by unexposed (unacclimated) and long-term exposed (acclimated) biomass were quantified using a modified fed-batch technique. The acclimated biomass was taken after approximately 1-year of operation from three lab-scale sequencing batch reactors (SBR). These reactors were operated under various cycling electron acceptor conditions with a continuous feed of a synthetic wastewater containing biogenic and nonbiogenic chemicals including benzoate, 3-nitrobenzoate, and 4-chlorophenol, but not 4-chlorobenzoate or 2,4-dichlorophenol. The unexposed biomass was taken from a full-scale wastewater treatment plant, which constituted one of the original sources of inoculum for the lab-scale SBRs. The acclimated biomass manifested high removal rates of benzoate and related aromatic compounds with additional removal of structurally similar chemicals (4-chlorobenzoate and 2,4-dichlorophenol). The unacclimated biomass showed no removal of 3-nitrobenzoate, 4-chlorobenzoate or 2,4-dichlorophenol. Addition of biogenic substrates reduced the degradation of most aromatic compounds tested, but it enhanced 2,4-dichlorophenol removal. Biodegradation rates of each aromatic compound with the biomass from the anoxic/aerobic SBR were further determined under anaerobic (absence of aeration and NO3-), anoxic (no aeration, but with surplus NO3-), standard oxygen (DO > 0.2 mg/L), and elevated oxygen (DO > 25 mg/L) conditions. The removal rate of both benzoate and 3-nitrobenzoate decreased under anaerobic condition but not under the anoxic condition; 4-chlorophenol biodegradation, on the other hand, was reduced significantly under both anoxic and anaerobic conditions. The removal rates of aromatic compounds, particularly those of 3-nitrobenzoate and 2,4-dichlorophenol, increased significantly under elevated dissolved oxygen conditions. Our results demonstrated that when the biochemical conditions shifted from oxygen-respiration to nitrate respiration, to anaerobiosis, the biodegradation rates of test aromatic compounds decreased or ceased.