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Oskarshamn is one of the municipalities being discussed as a possible site for disposal of nuclear waste from the Swedish nuclear power plants, and there has been inquiries made for a pilot study in the area. In view of this the local council of Oskarshamn appointed a ´Youth team´, consisting of ten young politicians from all political parties represented in the local council. The aim of the team was to inform and create debate among adolescents about how to store the radioactive waste from nuclear power plants. The purpose of this survey, addressed to young people in Oskarshamn, was to shed light on their opinion towards a pilot study and possible disposal of nuclear waste in Oskarshamn. The respondents had to answer questions about their opinion on the use of nuclear power in Sweden, if they believed nuclear power to be abolished by year 2010, and about their general interest in issues concerning energy and nuclear power. Other questions concerned risks associated with nuclear power, the influence different groups have/ought to have when it comes to disposal of nuclear waste, and if the respondent would accept a decision to dispose nuclear waste in Oskarshamn. A number of questions dealt with the suggested pilot study; if the respondent was for or against a pilot study; who should decide about the pilot study; if there had been enough information about the study; and if the respondent had attended any meeting, signed any petition, contacted any politician, contacted or participated in mass media, or tried to influence anyone´s opinion on any issue concerning the pilot study. The respondents also had to state the issues they considered to be important to study in a pilot study. Furthermore the respondents had to give their opinion about a number of risks discussed in connection with disposal of nuclear waste in Oskarshamn. Other questions concerned the influence on job opportunities and tourism. Demographic items include age, gender, marital status, children, education, occupation, and trade union membership. Oskarshamn is one of the municipalities being discussed as a possible site for disposal of nuclear waste from the Swedish nuclear power plants, and there has been inquiries made for a pilot study in the area. In view of this the local council of Oskarshamn appointed a 'Youth team', consisting of ten young politicians from all political parties represented in the local council. The aim of the team was to inform and create debate among adolescents about how to store the radioactive waste from nuclear power plants. The purpose of this survey, addressed to young people in Oskarshamn, was to shed light on their opinion towards a pilot study and possible disposal of nuclear waste in Oskarshamn. The respondents had to answer questions about their opinion on the use of nuclear power in Sweden, if they believed nuclear power to be abolished by year 2010, and about their general interest in issues concerning energy and nuclear power. Other questions concerned risks associated with nuclear power, the influence different groups have/ought to have when it comes to disposal of nuclear waste, and if the respondent would accept a decision to dispose nuclear waste in Oskarshamn. A number of questions dealt with the suggested pilot study; if the respondent was for or against a pilot study; who should decide about the pilot study; if there had been enough information about the study; and if the respondent had attended any meeting, signed any petition, contacted any politician, contacted or participated in mass media, or tried to influence anyone's opinion on any issue concerning the pilot study. The respondents also had to state the issues they considered to be important to study in a pilot study. Furthermore the respondents had to give their opinion about a number of risks discussed in connection with disposal of nuclear waste in Oskarshamn. Other questions concerned the influence on job opportunities and tourism. Demographic items include age, gender, marital status, children, education, occupation, and trade union membership.

Diesel engine exhausts from a common rail 3.0 L F1C diesel engine were analyzed at two different load conditions of the WLTC testing cycle downstream of both the diesel particulate filter (DPF) and selective catalytic reactor (SCR) to verify their effect on the characteristics of carbon particulate matter. An array of chemical, physical and spectroscopic techniques (gas chromatography coupled with mass spectrometry (GC-MS), mobility analyzer, UV-Visible absorption and fluorescence spectroscopy) was applied for characterizing polycyclic aromatic hydrocarbons (PAH), heavy aromatic compounds and soot, constituting the particulate matter (PM) sampled from the exhaust. The engine was operated in half load (HL) (188 Nm, representing the more common condition for engine in urban traffic) and full load (FL) (452 Nm, representing the best performance of the engine operation) conditions, at the same engine speed (2000 rpm). Soot formation was enhanced in HL condition, with respect to FL, but, just because of the much lower soot amount, the after-treatment systems in this last condition resulted to be less efficient in the soot abatement. Indeed, the abatement through DPF was about 40% lower in the FL condition with respect to HL condition, and any significant further concentration decrease was found after SCR, in both conditions. By contrast, PAH concentration after DPF abatement was found to be higher in the HL with respect to FL condition. A further PAH concentration decrease of about 30% was found after the SCR in the HL condition whereas in FL the reduction was only about 5-6%. Also the heavy aromatic compounds having molecular weight above the GC-MS detection limit (300 u), were mitigated by SCR. Therefore, SCR did not cause a further soot reduction, whereas it was effective in largely reducing PAH and heavy aromatics emissions, especially in the lower temperature condition featuring the half-load condition, when combustion efficiency is worse. Moreover, SCR system reduced the emission of small particles probably due to an enhanced agglomeration of particles, with beneficial effect on the harmfulness to human health.

Green tea catechins mixed with caffeine have been proposed as adjuvants for maintaining or enhancing energy expenditure and for increasing fat oxidation, in the context of prevention and treatment of obesity. These catechins-caffeine mixtures seem to counteract the decrease in metabolic rate that occurs during weight loss. Their effects are of particular importance during weight maintenance after weight loss. Other metabolic targets may be fat absorption and the gut microbiota composition, but these effects still need further investigation in combination with weight loss. Limitations for the effects of green tea catechins are moderating factors such as genetic predisposition related to COMT-activity, habitual caffeine intake, and ingestion combined with dietary protein. In conclusion, a mixture of green tea catechins and caffeine has a beneficial effect on body-weight management, especially by sustained energy expenditure, fat oxidation, and preservation of fat free body-mass, after energy restriction induced body-weight loss, when taking the limitations into account.

AbstractThe protic ionic liquid (PIL) N‐butylimidazolium trifluoromethanesulfonate ([BIm][TfO]) was obtained for the first time and incorporated into a sol–gel‐derived di‐ureasil matrix with a concentration of X=5, 10, and 30 %, where X is the ratio of the mass of PIL per mass of poly(oxyethylene). Four years after their synthesis, the resulting quasi‐anhydrous electrolytes remained amorphous, homogeneous, flexible, and thermally stable below 200 °C. SEM/EDS data revealed the presence of the PIL at the surface of the xerogels with X>5 %, demonstrating that this type of morphological characterization is mandatory to avoid misleading ionic conductivity values. The highest ionic conductivity was produced in the washed sample with X=30 % (3.5×10−5 and 2.1×10−3 S cm−1 at 25 and 170 °C, respectively). The present family of electrolytes yielded higher conductivities than the N‐ethylimidazolium trifluoromethanesulfonate‐based analogues introduced earlier by our group and may thus be considered as promising candidates for applications in fuel cells.

While the harmful effects of alcohol abuse are well documented, experimental and clinical data support a potential benefit of light to moderate alcohol consumption. Cross-sectional studies have suggested an association between alcohol consumption and multiple sclerosis (MS) disability. In the absence of prospective, longitudinal studies, the causal nature of this relationship cannot be established. It remains possible that patients with increased disability progression reduce their alcohol intake. Even though there is substantial evidence for anti-inflammatory effects of low-to-moderate doses of alcohol, the associations need to be interpreted very cautiously. This study discusses the current state of knowledge about MS and alcohol consumption, and the limitations in conducting research with retrospective data in patients with MS.

Activity pacing (AP) is a concept that is central to many chronic pain theories and treatments, yet there remains confusion regarding its definition and effects.To review the current knowledge concerning AP and integrate this knowledge in a manner that allows for a clear definition and useful directions for future research.A narrative review of the major theoretical approaches to AP and of the empirical evidence regarding the effects of AP interventions, followed by an integrative discussion.The concept of AP is derived from 2 main traditions: operant and energy conservation. Although there are common elements across these traditions, significant conceptual and practical differences exist, which has led to confusion. Little empirical evidence exists concerning the efficacy of AP as a treatment for chronic pain.Future research on AP should be based on a clear theoretical foundation, consider the context in which the AP behavior occurs and the type of pacing problem ("underactivity" vs. "overactivity"), and should examine the impact of AP treatment on multiple clinical outcomes. We provide a provisional definition of AP and specific recommendations that we believe will move the field forward.

Systemic delivery of therapeutic agents remains ineffective against diffuse intrinsic pontine glioma (DIPG), possibly due to an intact blood-brain-barrier (BBB) and to dose-limiting toxicity of systemic chemotherapeutic agents. Convection-enhanced delivery (CED) into the brainstem may provide an effective local delivery alternative for DIPG patients.The aim of this study is to develop a method to perform CED into the murine brainstem and to test this method using the chemotherapeutic agent carmustine (BiCNU). To this end, a newly designed murine CED catheter was tested in vitro and in vivo. After determination of safety and distribution, mice bearing VUMC-DIPG-3 and E98FM-DIPG brainstem tumors were treated with carmustine dissolved in DW 5% or carmustine dissolved in 10% ethanol.Our results show that CED into the murine brainstem is feasible and well tolerated by mice with and without brainstem tumors. CED of carmustine dissolved in 5% DW increased median survival of mice with VUMC-DIPG-3 and E98FM-DIPG tumors with 35% and 25% respectively. Dissolving carmustine in 10% ethanol further improved survival to 45% in mice with E98FM-DIPG tumors.Since genetically engineered and primary DIPG models are currently only available in mice, murine CED studies have clear advantages over CED studies in other animals.CED in the murine brainstem can be performed safely, is well tolerated and can be used to study efficacy of chemotherapeutic agents orthotopically. These results set the foundation for more CED studies in murine DIPG models.

There is ongoing debate regarding the validity of the distinction of alcohol abuse and dependence, the distinction between normality and alcohol abuse, and the absence of craving in the DSM-IV classification of alcohol use disorders. In this study, we examine the discriminant validity of the DSM-IV alcohol use disorder diagnoses in three different populations (98 patients from an alcohol treatment service, 68 nontreatment-seeking heavy drinkers, and 75 psychiatric outpatients). We compare the results of the DSM-IV classification with an alternative classification that requires craving and withdrawal for the diagnosis of dependence and at least two DSM-IV abuse-dependence symptoms for the diagnosis of abuse: the Craving Withdrawal Model (CWM). Although the total prevalence of any alcohol use disorder did not differ between DSM-IV and CWM, the distinction between normality and abuse and between abuse and dependence was better for the CWM categories.