- home
- Search
Filters
Clear All- Energy Research
- 6. Clean water
- AU
- FI
- Neuroscience
- Energy Research
- 6. Clean water
- AU
- FI
- Neuroscience
description Publicationkeyboard_double_arrow_right Article , Journal 1991Publisher:Elsevier BV Ken-ichi Kato; Nagao Suzuki; Yasuo Gomi; Hideo Kato; Yuji Iwanaga; Kouji Morikawa; Tatsuya Kimura; Yasuo Ito;doi: 10.1254/jjp.61.277 , 10.1254/jjp.61.333 , 10.1254/jjp.62.289 , 10.1254/jjp.61.341 , 10.1254/jjp.62.379 , 10.1254/jjp.62.161 , 10.1254/jjp.62.1 , 10.1254/jjp.62.9 , 10.1254/jjp.62.269 , 10.1254/jjp.61.283 , 10.1254/jjp.62.99 , 10.1254/jjp.62.123 , 10.1254/jjp.61.299 , 10.1254/jjp.61.351 , 10.1254/jjp.61.291 , 10.1254/jjp.61.325 , 10.1254/jjp.62.387 , 10.1254/jjp.62.183 , 10.1254/jjp.61.375 , 10.1254/jjp.62.49 , 10.1254/jjp.62.111 , 10.1254/jjp.62.103 , 10.1016/s0021-5198(19)39119-x , 10.1254/jjp.62.373 , 10.1254/jjp.62.263 , 10.1016/1056-8719(94)90054-x , 10.1254/jjp.62.415 , 10.1254/jjp.62.339 , 10.1254/jjp.62.169 , 10.1254/jjp.62.75 , 10.1254/jjp.62.131 , 10.1254/jjp.62.175 , 10.1254/jjp.62.223 , 10.1016/0921-8696(92)90705-6 , 10.1254/jjp.62.199 , 10.1254/jjp.62.325 , 10.1254/jjp.62.215 , 10.1254/jjp.62.279 , 10.1254/jjp.62.211 , 10.1254/jjp.62.57 , 10.1254/jjp.62.107 , 10.1254/jjp.62.329 , 10.1254/jjp.62.331 , 10.1254/jjp.62.395 , 10.1254/jjp.62.67 , 10.1254/jjp.62.419
pmid: 8105126 , 8391605 , 8341031 , 8371515 , 8320874 , 8101883 , 8101886 , 8320884 , 8230864 , 8320879 , 8391606 , 7693993 , 8230869 , 8411779 , 8101884 , 8230865 , 8411775 , 8371517 , 8371516 , 8230860 , 7901446 , 7688057 , 8411771 , 7688056 , 8103809 , 8411776 , 8371514 , 8230866 , 8105123 , 8105124 , 7690431 , 8320878 , 8411770 , 8341029 , 8320875 , 8100594 , 8320880 , 8341023 , 8230867 , 8341024 , 7688055
doi: 10.1254/jjp.61.277 , 10.1254/jjp.61.333 , 10.1254/jjp.62.289 , 10.1254/jjp.61.341 , 10.1254/jjp.62.379 , 10.1254/jjp.62.161 , 10.1254/jjp.62.1 , 10.1254/jjp.62.9 , 10.1254/jjp.62.269 , 10.1254/jjp.61.283 , 10.1254/jjp.62.99 , 10.1254/jjp.62.123 , 10.1254/jjp.61.299 , 10.1254/jjp.61.351 , 10.1254/jjp.61.291 , 10.1254/jjp.61.325 , 10.1254/jjp.62.387 , 10.1254/jjp.62.183 , 10.1254/jjp.61.375 , 10.1254/jjp.62.49 , 10.1254/jjp.62.111 , 10.1254/jjp.62.103 , 10.1016/s0021-5198(19)39119-x , 10.1254/jjp.62.373 , 10.1254/jjp.62.263 , 10.1016/1056-8719(94)90054-x , 10.1254/jjp.62.415 , 10.1254/jjp.62.339 , 10.1254/jjp.62.169 , 10.1254/jjp.62.75 , 10.1254/jjp.62.131 , 10.1254/jjp.62.175 , 10.1254/jjp.62.223 , 10.1016/0921-8696(92)90705-6 , 10.1254/jjp.62.199 , 10.1254/jjp.62.325 , 10.1254/jjp.62.215 , 10.1254/jjp.62.279 , 10.1254/jjp.62.211 , 10.1254/jjp.62.57 , 10.1254/jjp.62.107 , 10.1254/jjp.62.329 , 10.1254/jjp.62.331 , 10.1254/jjp.62.395 , 10.1254/jjp.62.67 , 10.1254/jjp.62.419
pmid: 8105126 , 8391605 , 8341031 , 8371515 , 8320874 , 8101883 , 8101886 , 8320884 , 8230864 , 8320879 , 8391606 , 7693993 , 8230869 , 8411779 , 8101884 , 8230865 , 8411775 , 8371517 , 8371516 , 8230860 , 7901446 , 7688057 , 8411771 , 7688056 , 8103809 , 8411776 , 8371514 , 8230866 , 8105123 , 8105124 , 7690431 , 8320878 , 8411770 , 8341029 , 8320875 , 8100594 , 8320880 , 8341023 , 8230867 , 8341024 , 7688055
We investigated the subtype of alpha-adrenoceptors participating in central noradrenergic inhibition of gastric motility in urethane-anesthetized rats. Noradrenaline at 10 nmole administered intracisternally (i.c.) significantly decreased gastric motility. Yohimbine at 10 nmole, i.c., but not the same dose of prazosin, abolished this noradrenaline-induced decrease in gastric motility. Clonidine at 10 nmole, i.c., but not phenylephrine at 20 nmole, significantly decreased gastric motility. These results suggest that alpha 2-adrenoceptor-mediated mechanisms in the brain stem are involved in noradrenergic inhibitory regulation of gastric motility.
The Japanese Journal... arrow_drop_down The Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1991 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefJournal of Pharmacological and Toxicological MethodsArticle . 1994 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefNeuroscience Research SupplementsArticle . 1992 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1254/jjp.61.277&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesgold 521 citations 521 popularity Top 10% influence Top 1% impulse Top 1% 
Powered by BIP!more_vert The Japanese Journal... arrow_drop_down The Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1991 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefJournal of Pharmacological and Toxicological MethodsArticle . 1994 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefNeuroscience Research SupplementsArticle . 1992 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1254/jjp.61.277&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1976Publisher:Elsevier BV Authors: Jorma Hirvonen;pmid: 976901
A series of 22 cases of fatal accidental or suicidal hypothermia is presented. Necropsy findings on which the diagnosis can be based were analysed. Purple skin and swelling of face, hands and feet, as well as violet patches on elbows or knees were the most frequent external signs (Frequency 54--59%). The most conspicuous internal macroscopic signs were gastric erosions or haemorrhages, which were seen in half of the cases. Other less frequent signs were pulmonary oedema and acute renal and hepatic degeneration. Microscopically the myocardium showed small degenerative foci and/or fuchsinophilic fibres in two thirds of the cases. The myocardium was macroscopically normal. Histamine and serotonin assays from urine did not indicate increased excretion during exposure. Catecholamine concentrations in urine were high (greater than 0.1 mug/ml) in most hypothermia deaths indicating increased excretion due to cold. The best diagnostic signs seem to be purple skin and oedema in face and ears, stomach erosions, degenerative foci in myocardium and high concentration of catecholamines in the urine.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0300-9432(76)90059-5&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesbronze 93 citations 93 popularity Top 10% influence Top 10% impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0300-9432(76)90059-5&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1974Publisher:Elsevier BV Authors: Mustala O; Matti Kekki; P. J. Pentikäinen;pmid: 4412193
Carbon-14-labeled 5-hydroxytryptamine (5HT) was administered intraportally to normal and cirrhotic rats, and urine and bile were collected periodically for periods up to 6, and occasionally up to 10 hr. 14C-labeled 5HT metabolites were separated with the use of two-dimensional paper chromatography, and the radioactivity of nine metabolites of 5HT was measured. Cirrhotic rats excreted 14C metabolites into urine in less quantity than did normal rats. In addition, the biliary excretion of 14C-labeled 5HT metabolites was markedly depressed in cirrhotic rats. The preferential occurrence of glucuronide conjugates was demonstrated in both the urine and bile of cirrhotic animals. 14C-labeled 5-hydroxytryptophol conjugates decreased and relabeled 5HT conjugates increased in cirrhotic rats. In normal animals, at least one-third of the 14C-labeled 5HT metabolites excreted into the bile go through the enterohepatic circulation, and a significant proportion of these can be found again in bile after intrajejunal administration of prelabeled bile.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0016-5085(19)32797-0&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0016-5085(19)32797-0&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2019Publisher:Springer Science and Business Media LLC L. Y. Lin; S. Y. Luo; M. Al-Hawwas; M. F. Herselman; X. F. Zhou; Larisa Bobrovskaya;pmid: 31127538
In this study, we aimed to establish the effects of chronic corticosterone (CORT) and ethanol administration on mood-related behaviour and the levels of mature brain-derived neurotrophic factor (mBDNF) and its precursor protein proBDNF in mice. C57BL6 male and female mice received drinking water (n = 22), 1% ethanol in drinking water (n = 16) or 100 μg/ml corticosterone in drinking water (containing 1% ethanol, n = 18) for 4.5 weeks. At the end of experimental protocol, the open field test (OFT) and elevated plus maze test were performed. Brain and adrenal tissues were collected and mBDNF and proBDNF were measured by ELISA assays. We found that the mice fed with corticosterone and ethanol developed anxiety-like behaviours as evidenced by reduced time in the central zone in the OFT compared with the control group. Both proBDNF and mBDNF were significantly decreased in the corticosterone and ethanol groups compared with the control group in the prefrontal cortex, hippocampus, hypothalamus and adrenal. The ratio of proBDNF/mBDNF in prefrontal cortex in the corticosterone group was increased compared with the ethanol group. Our data suggest that the ratio of proBDNF/mBDNF is differentially regulated in different tissues. Ethanol and corticosterone downregulate both mBDNF and proBDNF and alter the balance of proBDNF/mBDNF in some tissues. In conclusion, the ethanol and corticosterone may cause abnormal regulation of mBDNF and proBDNF which may lead to mood disorders.
Journal of Molecular... arrow_drop_down Journal of Molecular NeuroscienceArticle . 2019 . Peer-reviewedLicense: Springer TDMData sources: CrossrefAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12031-019-01328-6&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesbronze 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Molecular... arrow_drop_down Journal of Molecular NeuroscienceArticle . 2019 . Peer-reviewedLicense: Springer TDMData sources: CrossrefAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12031-019-01328-6&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 AustraliaPublisher:MDPI AG Authors: Marlou Mackus; Aurora J. A. E. van de Loo; Willie J. M. van den Bogaard; Gerdien A. H. Korte-Bouws; +2 AuthorsMarlou Mackus; Aurora J. A. E. van de Loo; Willie J. M. van den Bogaard; Gerdien A. H. Korte-Bouws; Johan Garssen; Joris C. Verster;Assessment of the presence and severity of alcohol hangovers relies on the subjective method of self-report. Therefore, there is a need of adequate biomarkers that (1) correlate significantly with hangover severity, and (2) correspond to the level of hangover-related performance impairment objectively. In this naturalistic study, n = 35 social drinkers participated. Urine samples were obtained the morning after alcohol consumption and after an alcohol-free control day. Concentrations of 5-hydroxytryptophol (5-HTOL), 5-hydroxyindoleacetic acid (5-HIAA) and the 5-HTOL/5-HIAA ratio were determined. The results confirm previous findings that 5-HTOL and the 5HTOL/5-HIAA ratio are useful biomarkers of recent alcohol consumption. Significant correlations were found with the amount of alcohol consumed, total drink time, and estimated BAC. However, urine concentrations of 5-HTOL and 5-HIAA (and their ratio 5HTOL/5-HIAA) did not significantly correlate with hangover severity. In conclusion, urine 5-HTOL, 5-HIAA, and the 5HTOL/5-HIAA ratio cannot be considered to be suitable biomarkers of alcohol hangover.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/jcm10184241&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/jcm10184241&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu
description Publicationkeyboard_double_arrow_right Article , Journal 1991Publisher:Elsevier BV Ken-ichi Kato; Nagao Suzuki; Yasuo Gomi; Hideo Kato; Yuji Iwanaga; Kouji Morikawa; Tatsuya Kimura; Yasuo Ito;doi: 10.1254/jjp.61.277 , 10.1254/jjp.61.333 , 10.1254/jjp.62.289 , 10.1254/jjp.61.341 , 10.1254/jjp.62.379 , 10.1254/jjp.62.161 , 10.1254/jjp.62.1 , 10.1254/jjp.62.9 , 10.1254/jjp.62.269 , 10.1254/jjp.61.283 , 10.1254/jjp.62.99 , 10.1254/jjp.62.123 , 10.1254/jjp.61.299 , 10.1254/jjp.61.351 , 10.1254/jjp.61.291 , 10.1254/jjp.61.325 , 10.1254/jjp.62.387 , 10.1254/jjp.62.183 , 10.1254/jjp.61.375 , 10.1254/jjp.62.49 , 10.1254/jjp.62.111 , 10.1254/jjp.62.103 , 10.1016/s0021-5198(19)39119-x , 10.1254/jjp.62.373 , 10.1254/jjp.62.263 , 10.1016/1056-8719(94)90054-x , 10.1254/jjp.62.415 , 10.1254/jjp.62.339 , 10.1254/jjp.62.169 , 10.1254/jjp.62.75 , 10.1254/jjp.62.131 , 10.1254/jjp.62.175 , 10.1254/jjp.62.223 , 10.1016/0921-8696(92)90705-6 , 10.1254/jjp.62.199 , 10.1254/jjp.62.325 , 10.1254/jjp.62.215 , 10.1254/jjp.62.279 , 10.1254/jjp.62.211 , 10.1254/jjp.62.57 , 10.1254/jjp.62.107 , 10.1254/jjp.62.329 , 10.1254/jjp.62.331 , 10.1254/jjp.62.395 , 10.1254/jjp.62.67 , 10.1254/jjp.62.419
pmid: 8105126 , 8391605 , 8341031 , 8371515 , 8320874 , 8101883 , 8101886 , 8320884 , 8230864 , 8320879 , 8391606 , 7693993 , 8230869 , 8411779 , 8101884 , 8230865 , 8411775 , 8371517 , 8371516 , 8230860 , 7901446 , 7688057 , 8411771 , 7688056 , 8103809 , 8411776 , 8371514 , 8230866 , 8105123 , 8105124 , 7690431 , 8320878 , 8411770 , 8341029 , 8320875 , 8100594 , 8320880 , 8341023 , 8230867 , 8341024 , 7688055
doi: 10.1254/jjp.61.277 , 10.1254/jjp.61.333 , 10.1254/jjp.62.289 , 10.1254/jjp.61.341 , 10.1254/jjp.62.379 , 10.1254/jjp.62.161 , 10.1254/jjp.62.1 , 10.1254/jjp.62.9 , 10.1254/jjp.62.269 , 10.1254/jjp.61.283 , 10.1254/jjp.62.99 , 10.1254/jjp.62.123 , 10.1254/jjp.61.299 , 10.1254/jjp.61.351 , 10.1254/jjp.61.291 , 10.1254/jjp.61.325 , 10.1254/jjp.62.387 , 10.1254/jjp.62.183 , 10.1254/jjp.61.375 , 10.1254/jjp.62.49 , 10.1254/jjp.62.111 , 10.1254/jjp.62.103 , 10.1016/s0021-5198(19)39119-x , 10.1254/jjp.62.373 , 10.1254/jjp.62.263 , 10.1016/1056-8719(94)90054-x , 10.1254/jjp.62.415 , 10.1254/jjp.62.339 , 10.1254/jjp.62.169 , 10.1254/jjp.62.75 , 10.1254/jjp.62.131 , 10.1254/jjp.62.175 , 10.1254/jjp.62.223 , 10.1016/0921-8696(92)90705-6 , 10.1254/jjp.62.199 , 10.1254/jjp.62.325 , 10.1254/jjp.62.215 , 10.1254/jjp.62.279 , 10.1254/jjp.62.211 , 10.1254/jjp.62.57 , 10.1254/jjp.62.107 , 10.1254/jjp.62.329 , 10.1254/jjp.62.331 , 10.1254/jjp.62.395 , 10.1254/jjp.62.67 , 10.1254/jjp.62.419
pmid: 8105126 , 8391605 , 8341031 , 8371515 , 8320874 , 8101883 , 8101886 , 8320884 , 8230864 , 8320879 , 8391606 , 7693993 , 8230869 , 8411779 , 8101884 , 8230865 , 8411775 , 8371517 , 8371516 , 8230860 , 7901446 , 7688057 , 8411771 , 7688056 , 8103809 , 8411776 , 8371514 , 8230866 , 8105123 , 8105124 , 7690431 , 8320878 , 8411770 , 8341029 , 8320875 , 8100594 , 8320880 , 8341023 , 8230867 , 8341024 , 7688055
We investigated the subtype of alpha-adrenoceptors participating in central noradrenergic inhibition of gastric motility in urethane-anesthetized rats. Noradrenaline at 10 nmole administered intracisternally (i.c.) significantly decreased gastric motility. Yohimbine at 10 nmole, i.c., but not the same dose of prazosin, abolished this noradrenaline-induced decrease in gastric motility. Clonidine at 10 nmole, i.c., but not phenylephrine at 20 nmole, significantly decreased gastric motility. These results suggest that alpha 2-adrenoceptor-mediated mechanisms in the brain stem are involved in noradrenergic inhibitory regulation of gastric motility.
The Japanese Journal... arrow_drop_down The Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1991 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefJournal of Pharmacological and Toxicological MethodsArticle . 1994 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefNeuroscience Research SupplementsArticle . 1992 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1254/jjp.61.277&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesgold 521 citations 521 popularity Top 10% influence Top 1% impulse Top 1% Powered by BIP!more_vert The Japanese Journal... arrow_drop_down The Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1991 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefThe Japanese Journal of PharmacologyArticle . 1993 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefJournal of Pharmacological and Toxicological MethodsArticle . 1994 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefNeuroscience Research SupplementsArticle . 1992 . Peer-reviewedLicense: Elsevier TDMData sources: CrossrefAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1254/jjp.61.277&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1976Publisher:Elsevier BV Authors: Jorma Hirvonen;pmid: 976901
A series of 22 cases of fatal accidental or suicidal hypothermia is presented. Necropsy findings on which the diagnosis can be based were analysed. Purple skin and swelling of face, hands and feet, as well as violet patches on elbows or knees were the most frequent external signs (Frequency 54--59%). The most conspicuous internal macroscopic signs were gastric erosions or haemorrhages, which were seen in half of the cases. Other less frequent signs were pulmonary oedema and acute renal and hepatic degeneration. Microscopically the myocardium showed small degenerative foci and/or fuchsinophilic fibres in two thirds of the cases. The myocardium was macroscopically normal. Histamine and serotonin assays from urine did not indicate increased excretion during exposure. Catecholamine concentrations in urine were high (greater than 0.1 mug/ml) in most hypothermia deaths indicating increased excretion due to cold. The best diagnostic signs seem to be purple skin and oedema in face and ears, stomach erosions, degenerative foci in myocardium and high concentration of catecholamines in the urine.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0300-9432(76)90059-5&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesbronze 93 citations 93 popularity Top 10% influence Top 10% impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/0300-9432(76)90059-5&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 1974Publisher:Elsevier BV Authors: Mustala O; Matti Kekki; P. J. Pentikäinen;pmid: 4412193
Carbon-14-labeled 5-hydroxytryptamine (5HT) was administered intraportally to normal and cirrhotic rats, and urine and bile were collected periodically for periods up to 6, and occasionally up to 10 hr. 14C-labeled 5HT metabolites were separated with the use of two-dimensional paper chromatography, and the radioactivity of nine metabolites of 5HT was measured. Cirrhotic rats excreted 14C metabolites into urine in less quantity than did normal rats. In addition, the biliary excretion of 14C-labeled 5HT metabolites was markedly depressed in cirrhotic rats. The preferential occurrence of glucuronide conjugates was demonstrated in both the urine and bile of cirrhotic animals. 14C-labeled 5-hydroxytryptophol conjugates decreased and relabeled 5HT conjugates increased in cirrhotic rats. In normal animals, at least one-third of the 14C-labeled 5HT metabolites excreted into the bile go through the enterohepatic circulation, and a significant proportion of these can be found again in bile after intrajejunal administration of prelabeled bile.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0016-5085(19)32797-0&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesbronze 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/s0016-5085(19)32797-0&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2019Publisher:Springer Science and Business Media LLC L. Y. Lin; S. Y. Luo; M. Al-Hawwas; M. F. Herselman; X. F. Zhou; Larisa Bobrovskaya;pmid: 31127538
In this study, we aimed to establish the effects of chronic corticosterone (CORT) and ethanol administration on mood-related behaviour and the levels of mature brain-derived neurotrophic factor (mBDNF) and its precursor protein proBDNF in mice. C57BL6 male and female mice received drinking water (n = 22), 1% ethanol in drinking water (n = 16) or 100 μg/ml corticosterone in drinking water (containing 1% ethanol, n = 18) for 4.5 weeks. At the end of experimental protocol, the open field test (OFT) and elevated plus maze test were performed. Brain and adrenal tissues were collected and mBDNF and proBDNF were measured by ELISA assays. We found that the mice fed with corticosterone and ethanol developed anxiety-like behaviours as evidenced by reduced time in the central zone in the OFT compared with the control group. Both proBDNF and mBDNF were significantly decreased in the corticosterone and ethanol groups compared with the control group in the prefrontal cortex, hippocampus, hypothalamus and adrenal. The ratio of proBDNF/mBDNF in prefrontal cortex in the corticosterone group was increased compared with the ethanol group. Our data suggest that the ratio of proBDNF/mBDNF is differentially regulated in different tissues. Ethanol and corticosterone downregulate both mBDNF and proBDNF and alter the balance of proBDNF/mBDNF in some tissues. In conclusion, the ethanol and corticosterone may cause abnormal regulation of mBDNF and proBDNF which may lead to mood disorders.
Journal of Molecular... arrow_drop_down Journal of Molecular NeuroscienceArticle . 2019 . Peer-reviewedLicense: Springer TDMData sources: CrossrefAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12031-019-01328-6&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess Routesbronze 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Journal of Molecular... arrow_drop_down Journal of Molecular NeuroscienceArticle . 2019 . Peer-reviewedLicense: Springer TDMData sources: CrossrefAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s12031-019-01328-6&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 AustraliaPublisher:MDPI AG Authors: Marlou Mackus; Aurora J. A. E. van de Loo; Willie J. M. van den Bogaard; Gerdien A. H. Korte-Bouws; +2 AuthorsMarlou Mackus; Aurora J. A. E. van de Loo; Willie J. M. van den Bogaard; Gerdien A. H. Korte-Bouws; Johan Garssen; Joris C. Verster;Assessment of the presence and severity of alcohol hangovers relies on the subjective method of self-report. Therefore, there is a need of adequate biomarkers that (1) correlate significantly with hangover severity, and (2) correspond to the level of hangover-related performance impairment objectively. In this naturalistic study, n = 35 social drinkers participated. Urine samples were obtained the morning after alcohol consumption and after an alcohol-free control day. Concentrations of 5-hydroxytryptophol (5-HTOL), 5-hydroxyindoleacetic acid (5-HIAA) and the 5-HTOL/5-HIAA ratio were determined. The results confirm previous findings that 5-HTOL and the 5HTOL/5-HIAA ratio are useful biomarkers of recent alcohol consumption. Significant correlations were found with the amount of alcohol consumed, total drink time, and estimated BAC. However, urine concentrations of 5-HTOL and 5-HIAA (and their ratio 5HTOL/5-HIAA) did not significantly correlate with hangover severity. In conclusion, urine 5-HTOL, 5-HIAA, and the 5HTOL/5-HIAA ratio cannot be considered to be suitable biomarkers of alcohol hangover.
All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/jcm10184241&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/jcm10184241&type=result"></script>'); --> </script>For further information contact us at helpdesk@openaire.eu