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Measurement of Oxygen-Derived Free Radical Generation in the Regionally-Ischemic Rat Heart by the Chemiluminescence Method

doi: 10.1254/jjp.61.277 , 10.1254/jjp.61.333 , 10.1254/jjp.62.289 , 10.1254/jjp.61.341 , 10.1254/jjp.62.379 , 10.1254/jjp.62.161 , 10.1254/jjp.62.1 , 10.1254/jjp.62.9 , 10.1254/jjp.62.269 , 10.1254/jjp.61.283 , 10.1254/jjp.62.99 , 10.1254/jjp.62.123 , 10.1254/jjp.61.299 , 10.1254/jjp.61.351 , 10.1254/jjp.61.291 , 10.1254/jjp.61.325 , 10.1254/jjp.62.387 , 10.1254/jjp.62.183 , 10.1254/jjp.61.375 , 10.1254/jjp.62.49 , 10.1254/jjp.62.111 , 10.1254/jjp.62.103 , 10.1016/s0021-5198(19)39119-x , 10.1254/jjp.62.373 , 10.1254/jjp.62.263 , 10.1016/1056-8719(94)90054-x , 10.1254/jjp.62.415 , 10.1254/jjp.62.339 , 10.1254/jjp.62.169 , 10.1254/jjp.62.75 , 10.1254/jjp.62.131 , 10.1254/jjp.62.175 , 10.1254/jjp.62.223 , 10.1016/0921-8696(92)90705-6 , 10.1254/jjp.62.199 , 10.1254/jjp.62.325 , 10.1254/jjp.62.215 , 10.1254/jjp.62.279 , 10.1254/jjp.62.211 , 10.1254/jjp.62.57 , 10.1254/jjp.62.107 , 10.1254/jjp.62.329 , 10.1254/jjp.62.331 , 10.1254/jjp.62.395 , 10.1254/jjp.62.67 , 10.1254/jjp.62.419
pmid: 8105126 , 8391605 , 8341031 , 8371515 , 8320874 , 8101883 , 8101886 , 8320884 , 8230864 , 8320879 , 8391606 , 7693993 , 8230869 , 8411779 , 8101884 , 8230865 , 8411775 , 8371517 , 8371516 , 8230860 , 7901446 , 7688057 , 8411771 , 7688056 , 8103809 , 8411776 , 8371514 , 8230866 , 8105123 , 8105124 , 7690431 , 8320878 , 8411770 , 8341029 , 8320875 , 8100594 , 8320880 , 8341023 , 8230867 , 8341024 , 7688055
handle: 11570/2328226 , 11570/1682501
doi: 10.1254/jjp.61.277 , 10.1254/jjp.61.333 , 10.1254/jjp.62.289 , 10.1254/jjp.61.341 , 10.1254/jjp.62.379 , 10.1254/jjp.62.161 , 10.1254/jjp.62.1 , 10.1254/jjp.62.9 , 10.1254/jjp.62.269 , 10.1254/jjp.61.283 , 10.1254/jjp.62.99 , 10.1254/jjp.62.123 , 10.1254/jjp.61.299 , 10.1254/jjp.61.351 , 10.1254/jjp.61.291 , 10.1254/jjp.61.325 , 10.1254/jjp.62.387 , 10.1254/jjp.62.183 , 10.1254/jjp.61.375 , 10.1254/jjp.62.49 , 10.1254/jjp.62.111 , 10.1254/jjp.62.103 , 10.1016/s0021-5198(19)39119-x , 10.1254/jjp.62.373 , 10.1254/jjp.62.263 , 10.1016/1056-8719(94)90054-x , 10.1254/jjp.62.415 , 10.1254/jjp.62.339 , 10.1254/jjp.62.169 , 10.1254/jjp.62.75 , 10.1254/jjp.62.131 , 10.1254/jjp.62.175 , 10.1254/jjp.62.223 , 10.1016/0921-8696(92)90705-6 , 10.1254/jjp.62.199 , 10.1254/jjp.62.325 , 10.1254/jjp.62.215 , 10.1254/jjp.62.279 , 10.1254/jjp.62.211 , 10.1254/jjp.62.57 , 10.1254/jjp.62.107 , 10.1254/jjp.62.329 , 10.1254/jjp.62.331 , 10.1254/jjp.62.395 , 10.1254/jjp.62.67 , 10.1254/jjp.62.419
pmid: 8105126 , 8391605 , 8341031 , 8371515 , 8320874 , 8101883 , 8101886 , 8320884 , 8230864 , 8320879 , 8391606 , 7693993 , 8230869 , 8411779 , 8101884 , 8230865 , 8411775 , 8371517 , 8371516 , 8230860 , 7901446 , 7688057 , 8411771 , 7688056 , 8103809 , 8411776 , 8371514 , 8230866 , 8105123 , 8105124 , 7690431 , 8320878 , 8411770 , 8341029 , 8320875 , 8100594 , 8320880 , 8341023 , 8230867 , 8341024 , 7688055
handle: 11570/2328226 , 11570/1682501
Measurement of Oxygen-Derived Free Radical Generation in the Regionally-Ischemic Rat Heart by the Chemiluminescence Method
We investigated the subtype of alpha-adrenoceptors participating in central noradrenergic inhibition of gastric motility in urethane-anesthetized rats. Noradrenaline at 10 nmole administered intracisternally (i.c.) significantly decreased gastric motility. Yohimbine at 10 nmole, i.c., but not the same dose of prazosin, abolished this noradrenaline-induced decrease in gastric motility. Clonidine at 10 nmole, i.c., but not phenylephrine at 20 nmole, significantly decreased gastric motility. These results suggest that alpha 2-adrenoceptor-mediated mechanisms in the brain stem are involved in noradrenergic inhibitory regulation of gastric motility.
- Yamaguchi University Japan
- Fukuyama University Japan
- Saga Medical School Hospital Japan
- Hiroshima University Japan
- Oklahoma City University United States
Dihydropyridines, Swine, Pyridines, Muscle Relaxation, Methyltyrosines, Nicotinic Antagonists, Substance P, Kynurenic Acid, PC12 Cells, Synaptic Transmission, 2-Pyridinylmethylsulfinylbenzimidazoles, Brain Ischemia, Methamphetamine, Phosphatidylcholine-Sterol O-Acyltransferase, Rats, Sprague-Dawley, Mice, Adenosine Triphosphate, tert-Butylhydroperoxide, Pregnancy, Benzene Derivatives, Benzoquinones, Anesthesia, Hypoxia, Cyclic GMP, Injections, Spinal, Cells, Cultured, Pylorus, Decerebrate State, Mice, Inbred ICR, Morphine, Respiration, Stomach, Yohimbine, Stereoisomerism, Papillary Muscles, Hydrogen-Ion Concentration, Propranolol, Pyrrolidinones, Circadian Rhythm, Quinuclidinyl Benzilate, Survival Rate, Phrenic Nerve, Perfusion, Spinal Cord, Microsomes, Liver, Anticonvulsants, Sodium-Potassium-Exchanging ATPase, Supraoptic Nucleus, Adrenergic alpha-Agonists, Nitroprusside, Serotonin, Nicotine, N-Methylaspartate, Tyrosine 3-Monooxygenase, Arsenites, Hypercholesterolemia, Diaphragm, Radioimmunoassay, Nitric Oxide, Losartan, Quinoxalines, Reflex, Pyrroles, Stomach Ulcer, Rats, Wistar, Swimming, Dose-Response Relationship, Drug, Pepsinogens, Isoproterenol, Water, Lidocaine, Parasympatholytics, Muscle, Smooth, Rubidium, Arginine Vasopressin, Enzyme Activation, Dithiothreitol, Thiazoles, 2-Amino-5-phosphonovalerate, Bucladesine, Vasoconstriction, Synapses, Nerve Degeneration, Potassium, Cats, Haloperidol, Central Nervous System Stimulants, Benzimidazoles, Ureter, Reactive Oxygen Species, Peptides, Time Factors, Phosphodiesterase Inhibitors, Dopamine, Tetrazolium Salts, Action Potentials, Tetrazoles, Aorta, Thoracic, Satiety Response, Ion Channels, omega-Conotoxins, Membrane Potentials, Potassium Chloride, Diltiazem, Catecholamines, Nerve Fibers, Glutamates, Piperidines, Heart Rate, Escape Reaction, Glyburide, Fructosediphosphates, Vitamin D, Evoked Potentials, Biotransformation, gamma-Aminobutyric Acid, Protein Kinase C, Aorta, Glutathione Transferase, Receptors, Angiotensin, Gastric Juice, Cell Death, Muscles, Hydrolysis, Sympathectomy, Chemical, 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Imidazoles, Motor Cortex, Adrenalectomy, Microspheres, Carotid Arteries, Rabbits, Diterpenes, Atrial Natriuretic Factor, Protein Binding, Antipsychotic Agents, Muscle Contraction, Cromakalim, Nisoldipine, Histamine Antagonists, Myenteric Plexus, Arginine, Tritium, Sincalide, Clonidine, Injections, Arsenic, Diglycerides, Gastric Acid, Prosencephalon, Dogs, cerebral ischemia; neuronal death; fructose-1; 6-bisphosphate, GTP-Binding Proteins, Seizures, Coronary Circulation, Animals, Cysteine, Phentolamine, Vinca Alkaloids, Electrodes, Serum Albumin, Adrenergic alpha-Antagonists, Injections, Intraventricular, Brain Chemistry, Aspartic Acid, Membranes, Superoxide Dismutase, Myocardial Contraction, Corpus Striatum, Rats, alpha-Methyltyrosine, Gastric Mucosa, Pindolol, Adenylyl Cyclase Inhibitors, Abietanes, Pentylenetetrazole, Carbachol, Indicators and Reagents, Calcium, Capsaicin, Phosphatidylinositol 4,5-Diphosphate, Male, Imipramine, Taurine, Arteriosclerosis, Vasodilator Agents, Blood Pressure, Mecamylamine, Nitroarginine, Histamine Release, Muscle, Smooth, Vascular, Levodopa, Phosphatidylinositol Phosphates, Dimaprit, Pyloric Antrum, Electrochemistry, Parotid Gland, Receptors, Cholinergic, Magnesium, Amino Acids, 4-Aminopyridine, Chromatography, High Pressure Liquid, 6-Cyano-7-nitroquinoxaline-2,3-dione, Cerebral Cortex, Neurons, Isoflurane, Behavior, Animal, Brain, Gastric Acidity Determination, Iontophoresis, Peroxides, Femoral Artery, Cholesterol, Histamine H2 Antagonists, Ischemic Attack, Transient, Electrophoresis, Polyacrylamide Gel, Cimetidine, Ion Channel Gating, Omeprazole, Vasoactive Intestinal Peptide, Lipid Peroxides, Nifedipine, Colon, Calcitonin Gene-Related Peptide, Scopolamine, Glycine, Hypothalamus, Calcium-Transporting ATPases, Tetrodotoxin, Receptors, N-Methyl-D-Aspartate, Retina, Choline O-Acetyltransferase, Structure-Activity Relationship, Alkaloids, Ileum, Parasympathetic Nervous System, Avoidance Learning, Humans, Biogenic Monoamines, Benzopyrans, Anaphylaxis, Pyrilamine, Ethanol, Electromyography, Phosphatidylethanolamines, Myocardium, Osmolar Concentration, Biphenyl Compounds, Respiration, Artificial, Electric Stimulation, Acetylcholine, Methotrexate, Regional Blood Flow, Acridines, Diet, Atherogenic, Cholinesterase Inhibitors, Dizocilpine Maleate, Gastrointestinal Motility, Drugs, Chinese Herbal, Sympathetic Nervous System, Pyrrolidines, Indoles, Potassium Channels, Ubiquinone, Myocardial Ischemia, Vagotomy, Isoindoles, Hippocampus, Chromatography, Affinity, Cholesterol, Dietary, Oxathiins, 5-Hydroxytryptophan, Iodine Radioisotopes, Eating, Norepinephrine, Cocaine, Drug Interactions, Mast Cells, Aorta, Abdominal, Analgesics, Kainic Acid, Angiotensin II, Proton Pumps, Oxidants, Calcium Channel Blockers, Coronary Vessels, Stimulation, Chemical, Recombinant Proteins, Dihydroxyphenylalanine, Electrophysiology, Sarcoplasmic Reticulum, Benzamides, Phosphatidylcholines, Ketamine, Female, Betahistine, Microinjections, Cell Survival, Guinea Pigs, Neuromuscular Junction, Glutamic Acid, Myocardial Reperfusion, Mice, Inbred Strains, Motor Activity, In Vitro Techniques, Autoimmune Diseases, Angiotensin Receptor Antagonists, Immobilization, Oxygen Consumption, Calmodulin, Chloride Channels, Benzyl Compounds, Sulfhydryl Compounds, Heart Atria, Binding Sites, Colforsin, Membrane Proteins, Prazosin, Intracranial Embolism and Thrombosis, Benzazepines, Receptors, Adrenergic, alpha, Anti-Ulcer Agents, Pepsin A, Diuresis, Kinetics, Ventromedial Hypothalamic Nucleus, Luminescent Measurements, Peristalsis, Lymph Nodes, Gerbillinae, Microelectrodes, Paraventricular Hypothalamic Nucleus, Brain Stem
Dihydropyridines, Swine, Pyridines, Muscle Relaxation, Methyltyrosines, Nicotinic Antagonists, Substance P, Kynurenic Acid, PC12 Cells, Synaptic Transmission, 2-Pyridinylmethylsulfinylbenzimidazoles, Brain Ischemia, Methamphetamine, Phosphatidylcholine-Sterol O-Acyltransferase, Rats, Sprague-Dawley, Mice, Adenosine Triphosphate, tert-Butylhydroperoxide, Pregnancy, Benzene Derivatives, Benzoquinones, Anesthesia, Hypoxia, Cyclic GMP, Injections, Spinal, Cells, Cultured, Pylorus, Decerebrate State, Mice, Inbred ICR, Morphine, Respiration, Stomach, Yohimbine, Stereoisomerism, Papillary Muscles, Hydrogen-Ion Concentration, Propranolol, Pyrrolidinones, Circadian Rhythm, Quinuclidinyl Benzilate, Survival Rate, Phrenic Nerve, Perfusion, Spinal Cord, Microsomes, Liver, Anticonvulsants, Sodium-Potassium-Exchanging ATPase, Supraoptic Nucleus, Adrenergic alpha-Agonists, Nitroprusside, Serotonin, Nicotine, N-Methylaspartate, Tyrosine 3-Monooxygenase, Arsenites, Hypercholesterolemia, Diaphragm, Radioimmunoassay, Nitric Oxide, Losartan, Quinoxalines, Reflex, Pyrroles, Stomach Ulcer, Rats, Wistar, Swimming, Dose-Response Relationship, Drug, Pepsinogens, Isoproterenol, Water, Lidocaine, Parasympatholytics, Muscle, Smooth, Rubidium, Arginine Vasopressin, Enzyme Activation, Dithiothreitol, Thiazoles, 2-Amino-5-phosphonovalerate, Bucladesine, Vasoconstriction, Synapses, Nerve Degeneration, Potassium, Cats, Haloperidol, Central Nervous System Stimulants, Benzimidazoles, Ureter, Reactive Oxygen Species, Peptides, Time Factors, Phosphodiesterase Inhibitors, Dopamine, Tetrazolium Salts, Action Potentials, Tetrazoles, Aorta, Thoracic, Satiety Response, Ion Channels, omega-Conotoxins, Membrane Potentials, Potassium Chloride, Diltiazem, Catecholamines, Nerve Fibers, Glutamates, Piperidines, Heart Rate, Escape Reaction, Glyburide, Fructosediphosphates, Vitamin D, Evoked Potentials, Biotransformation, gamma-Aminobutyric Acid, Protein Kinase C, Aorta, Glutathione Transferase, Receptors, Angiotensin, Gastric Juice, Cell Death, Muscles, Hydrolysis, Sympathectomy, Chemical, 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Imidazoles, Motor Cortex, Adrenalectomy, Microspheres, Carotid Arteries, Rabbits, Diterpenes, Atrial Natriuretic Factor, Protein Binding, Antipsychotic Agents, Muscle Contraction, Cromakalim, Nisoldipine, Histamine Antagonists, Myenteric Plexus, Arginine, Tritium, Sincalide, Clonidine, Injections, Arsenic, Diglycerides, Gastric Acid, Prosencephalon, Dogs, cerebral ischemia; neuronal death; fructose-1; 6-bisphosphate, GTP-Binding Proteins, Seizures, Coronary Circulation, Animals, Cysteine, Phentolamine, Vinca Alkaloids, Electrodes, Serum Albumin, Adrenergic alpha-Antagonists, Injections, Intraventricular, Brain Chemistry, Aspartic Acid, Membranes, Superoxide Dismutase, Myocardial Contraction, Corpus Striatum, Rats, alpha-Methyltyrosine, Gastric Mucosa, Pindolol, Adenylyl Cyclase Inhibitors, Abietanes, Pentylenetetrazole, Carbachol, Indicators and Reagents, Calcium, Capsaicin, Phosphatidylinositol 4,5-Diphosphate, Male, Imipramine, Taurine, Arteriosclerosis, Vasodilator Agents, Blood Pressure, Mecamylamine, Nitroarginine, Histamine Release, Muscle, Smooth, Vascular, Levodopa, Phosphatidylinositol Phosphates, Dimaprit, Pyloric Antrum, Electrochemistry, Parotid Gland, Receptors, Cholinergic, Magnesium, Amino Acids, 4-Aminopyridine, Chromatography, High Pressure Liquid, 6-Cyano-7-nitroquinoxaline-2,3-dione, Cerebral Cortex, Neurons, Isoflurane, Behavior, Animal, Brain, Gastric Acidity Determination, Iontophoresis, Peroxides, Femoral Artery, Cholesterol, Histamine H2 Antagonists, Ischemic Attack, Transient, Electrophoresis, Polyacrylamide Gel, Cimetidine, Ion Channel Gating, Omeprazole, Vasoactive Intestinal Peptide, Lipid Peroxides, Nifedipine, Colon, Calcitonin Gene-Related Peptide, Scopolamine, Glycine, Hypothalamus, Calcium-Transporting ATPases, Tetrodotoxin, Receptors, N-Methyl-D-Aspartate, Retina, Choline O-Acetyltransferase, Structure-Activity Relationship, Alkaloids, Ileum, Parasympathetic Nervous System, Avoidance Learning, Humans, Biogenic Monoamines, Benzopyrans, Anaphylaxis, Pyrilamine, Ethanol, Electromyography, Phosphatidylethanolamines, Myocardium, Osmolar Concentration, Biphenyl Compounds, Respiration, Artificial, Electric Stimulation, Acetylcholine, Methotrexate, Regional Blood Flow, Acridines, Diet, Atherogenic, Cholinesterase Inhibitors, Dizocilpine Maleate, Gastrointestinal Motility, Drugs, Chinese Herbal, Sympathetic Nervous System, Pyrrolidines, Indoles, Potassium Channels, Ubiquinone, Myocardial Ischemia, Vagotomy, Isoindoles, Hippocampus, Chromatography, Affinity, Cholesterol, Dietary, Oxathiins, 5-Hydroxytryptophan, Iodine Radioisotopes, Eating, Norepinephrine, Cocaine, Drug Interactions, Mast Cells, Aorta, Abdominal, Analgesics, Kainic Acid, Angiotensin II, Proton Pumps, Oxidants, Calcium Channel Blockers, Coronary Vessels, Stimulation, Chemical, Recombinant Proteins, Dihydroxyphenylalanine, Electrophysiology, Sarcoplasmic Reticulum, Benzamides, Phosphatidylcholines, Ketamine, Female, Betahistine, Microinjections, Cell Survival, Guinea Pigs, Neuromuscular Junction, Glutamic Acid, Myocardial Reperfusion, Mice, Inbred Strains, Motor Activity, In Vitro Techniques, Autoimmune Diseases, Angiotensin Receptor Antagonists, Immobilization, Oxygen Consumption, Calmodulin, Chloride Channels, Benzyl Compounds, Sulfhydryl Compounds, Heart Atria, Binding Sites, Colforsin, Membrane Proteins, Prazosin, Intracranial Embolism and Thrombosis, Benzazepines, Receptors, Adrenergic, alpha, Anti-Ulcer Agents, Pepsin A, Diuresis, Kinetics, Ventromedial Hypothalamic Nucleus, Luminescent Measurements, Peristalsis, Lymph Nodes, Gerbillinae, Microelectrodes, Paraventricular Hypothalamic Nucleus, Brain Stem
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