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description Publicationkeyboard_double_arrow_right Article , Other literature type , Journal , Preprint 2017Embargo end date: 08 Jun 2017 United KingdomPublisher:Cold Spring Harbor Laboratory Funded by:UKRI | Study of hypothalamic ami..., WTUKRI| Study of hypothalamic amino acid sensing pathways implicated in the regulation of energy balance ,WTAuthors: Luke K Burke; Tamana Darwish; Althea R Cavanaugh;Sam Virtue;
+10 AuthorsSam Virtue
Sam Virtue in OpenAIRELuke K Burke; Tamana Darwish; Althea R Cavanaugh;Sam Virtue;
Sam Virtue
Sam Virtue in OpenAIREEmma Roth;
Joanna Morro; Shun-Mei Liu; Jing Xia; Jeffrey W Dalley; Keith Burling; Streamson Chua; Toni Vidal-Puig; Gary J Schwartz;Emma Roth
Emma Roth in OpenAIREClémence Blouet;
Clémence Blouet
Clémence Blouet in OpenAIREAbstractEnergy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/110544&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/110544&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal , Preprint 2017Embargo end date: 08 Jun 2017 United KingdomPublisher:Cold Spring Harbor Laboratory Funded by:UKRI | Study of hypothalamic ami..., WTUKRI| Study of hypothalamic amino acid sensing pathways implicated in the regulation of energy balance ,WTAuthors: Luke K Burke; Tamana Darwish; Althea R Cavanaugh;Sam Virtue;
+10 AuthorsSam Virtue
Sam Virtue in OpenAIRELuke K Burke; Tamana Darwish; Althea R Cavanaugh;Sam Virtue;
Sam Virtue
Sam Virtue in OpenAIREEmma Roth;
Joanna Morro; Shun-Mei Liu; Jing Xia; Jeffrey W Dalley; Keith Burling; Streamson Chua; Toni Vidal-Puig; Gary J Schwartz;Emma Roth
Emma Roth in OpenAIREClémence Blouet;
Clémence Blouet
Clémence Blouet in OpenAIREAbstractEnergy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the brain to adjust iBAT activity and maintain energy homeostasis. Here we provide evidence that AGRP inhibitory tone to iBAT represents an energy-sparing circuit that integrates environmental food cues and internal signals of energy availability. We establish a role for the nutrient-sensing mTORC1 signaling pathway within AGRP neurons in the detection of environmental food cues and internal signals of energy availability, and in the bi-directional control of iBAT thermogenesis during nutrient deficiency and excess. Collectively, our findings provide insights into how mTORC1 signaling within AGRP neurons surveys energy availability to engage iBAT thermogenesis, and identify AGRP neurons as a neuronal substrate for the coordination of energy intake and adaptive expenditure under varying physiological and environmental contexts.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/110544&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 36 citations 36 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/110544&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2017 United StatesPublisher:eLife Sciences Publications, Ltd Funded by:EC | LTFCOFUND2013EC| LTFCOFUND2013Authors:Katarzyna Marta Zoltowska;
Katarzyna Marta Zoltowska
Katarzyna Marta Zoltowska in OpenAIREEleanna Kara;
Ksenia V. Kastanenka;Eleanna Kara
Eleanna Kara in OpenAIREMasato Maesako;
+8 AuthorsMasato Maesako
Masato Maesako in OpenAIREKatarzyna Marta Zoltowska;
Katarzyna Marta Zoltowska
Katarzyna Marta Zoltowska in OpenAIREEleanna Kara;
Ksenia V. Kastanenka;Eleanna Kara
Eleanna Kara in OpenAIREMasato Maesako;
Masato Maesako
Masato Maesako in OpenAIREOksana Berezovska;
Bradley T. Hyman;Oksana Berezovska
Oksana Berezovska in OpenAIRELaura J. Keller;
Xuejing Li; Sarah Svirsky; Jana Horlacher; Jana Horlacher; Brian J. Bacskai;Laura J. Keller
Laura J. Keller in OpenAIREThe high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ‘dephosphorylated’ states. However, the functional outcome of PS1 phosphorylation and its significance for Alzheimer’s disease (AD) pathogenesis is poorly understood. Here, comprehensive analysis using FRET-based imaging reveals that activity-driven and Protein Kinase A-mediated PS1 phosphorylation at three domains (domain 1: T74, domain 2: S310 and S313, domain 3: S365, S366, and S367), with S367 being critical, is responsible for the PS1 pathogenic ‘closed’ conformation, and resulting increase in the Aβ42/40 ratio. Moreover, we have established novel imaging assays for monitoring PS1 conformation in vivo, and report that PS1 phosphorylation induces the pathogenic conformational shift in the living mouse brain. These phosphorylation sites represent potential new targets for AD treatment.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.19720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.19720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2017 United StatesPublisher:eLife Sciences Publications, Ltd Funded by:EC | LTFCOFUND2013EC| LTFCOFUND2013Authors:Katarzyna Marta Zoltowska;
Katarzyna Marta Zoltowska
Katarzyna Marta Zoltowska in OpenAIREEleanna Kara;
Ksenia V. Kastanenka;Eleanna Kara
Eleanna Kara in OpenAIREMasato Maesako;
+8 AuthorsMasato Maesako
Masato Maesako in OpenAIREKatarzyna Marta Zoltowska;
Katarzyna Marta Zoltowska
Katarzyna Marta Zoltowska in OpenAIREEleanna Kara;
Ksenia V. Kastanenka;Eleanna Kara
Eleanna Kara in OpenAIREMasato Maesako;
Masato Maesako
Masato Maesako in OpenAIREOksana Berezovska;
Bradley T. Hyman;Oksana Berezovska
Oksana Berezovska in OpenAIRELaura J. Keller;
Xuejing Li; Sarah Svirsky; Jana Horlacher; Jana Horlacher; Brian J. Bacskai;Laura J. Keller
Laura J. Keller in OpenAIREThe high levels of serine (S) and threonine (T) residues within the Presenilin 1 (PS1) N-terminus and in the large hydrophilic loop region suggest that the enzymatic function of PS1/γ-secretase can be modulated by its ‘phosphorylated’ and ‘dephosphorylated’ states. However, the functional outcome of PS1 phosphorylation and its significance for Alzheimer’s disease (AD) pathogenesis is poorly understood. Here, comprehensive analysis using FRET-based imaging reveals that activity-driven and Protein Kinase A-mediated PS1 phosphorylation at three domains (domain 1: T74, domain 2: S310 and S313, domain 3: S365, S366, and S367), with S367 being critical, is responsible for the PS1 pathogenic ‘closed’ conformation, and resulting increase in the Aβ42/40 ratio. Moreover, we have established novel imaging assays for monitoring PS1 conformation in vivo, and report that PS1 phosphorylation induces the pathogenic conformational shift in the living mouse brain. These phosphorylation sites represent potential new targets for AD treatment.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.19720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.19720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United KingdomPublisher:eLife Sciences Publications, Ltd Funded by:WTWTAuthors:Kirsten A. Donald;
Kirsten A. Donald
Kirsten A. Donald in OpenAIREMahmoud Bukar Maina;
Mahmoud Bukar Maina
Mahmoud Bukar Maina in OpenAIRENilesh B. Patel;
Nilesh B. Patel
Nilesh B. Patel in OpenAIRECarine Nguemeni;
+13 AuthorsCarine Nguemeni
Carine Nguemeni in OpenAIREKirsten A. Donald;
Kirsten A. Donald
Kirsten A. Donald in OpenAIREMahmoud Bukar Maina;
Mahmoud Bukar Maina
Mahmoud Bukar Maina in OpenAIRENilesh B. Patel;
Nilesh B. Patel
Nilesh B. Patel in OpenAIRECarine Nguemeni;
Carine Nguemeni
Carine Nguemeni in OpenAIREWael Mohamed;
Wael Mohamed
Wael Mohamed in OpenAIREAmina Abubakar;
Amina Abubakar
Amina Abubakar in OpenAIREMatthew T. Brown;
Raliza Stoyanova;Matthew T. Brown
Matthew T. Brown in OpenAIREAndrew E. Welchman;
Natasha Walker;Andrew E. Welchman
Andrew E. Welchman in OpenAIREAlexis Willett;
Alexis Willett
Alexis Willett in OpenAIRESymon M. Kariuki;
Symon M. Kariuki
Symon M. Kariuki in OpenAIREAnthony Figaji;
Dan J. Stein;Anthony Figaji
Anthony Figaji in OpenAIREAmadi O. Ihunwo;
Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIREWillie M. U. Daniels;
Willie M. U. Daniels
Willie M. U. Daniels in OpenAIRECharles R. Newton;
Charles R. Newton
Charles R. Newton in OpenAIREpmid: 35731202
pmc: PMC9217128
Working in Africa provides neuroscientists with opportunities that are not available in other continents. Populations in this region exhibit the greatest genetic diversity; they live in ecosystems with diverse flora and fauna; and they face unique stresses to brain health, including child brain health and development, due to high levels of traumatic brain injury and diseases endemic to the region. However, the neuroscience community in Africa has yet to reach its full potential. In this article we report the outcomes from a series of meetings at which the African neuroscience community came together to identify barriers and opportunities, and to discuss ways forward. This exercise resulted in the identification of six domains of distinction in African neuroscience: the diverse DNA of African populations; diverse flora, fauna and ecosystems for comparative research; child brain health and development; the impact of climate change on mental and neurological health; access to clinical populations with important conditions less prevalent in the global North; and resourcefulness in the reuse and adaption of existing technologies and resources to answer new questions. The article also outlines plans to advance the field of neuroscience in Africa in order to unlock the potential of African neuroscientists to address regional and global mental health and neurological problems.
eLife arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.80488&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert eLife arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.80488&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United KingdomPublisher:eLife Sciences Publications, Ltd Funded by:WTWTAuthors:Kirsten A. Donald;
Kirsten A. Donald
Kirsten A. Donald in OpenAIREMahmoud Bukar Maina;
Mahmoud Bukar Maina
Mahmoud Bukar Maina in OpenAIRENilesh B. Patel;
Nilesh B. Patel
Nilesh B. Patel in OpenAIRECarine Nguemeni;
+13 AuthorsCarine Nguemeni
Carine Nguemeni in OpenAIREKirsten A. Donald;
Kirsten A. Donald
Kirsten A. Donald in OpenAIREMahmoud Bukar Maina;
Mahmoud Bukar Maina
Mahmoud Bukar Maina in OpenAIRENilesh B. Patel;
Nilesh B. Patel
Nilesh B. Patel in OpenAIRECarine Nguemeni;
Carine Nguemeni
Carine Nguemeni in OpenAIREWael Mohamed;
Wael Mohamed
Wael Mohamed in OpenAIREAmina Abubakar;
Amina Abubakar
Amina Abubakar in OpenAIREMatthew T. Brown;
Raliza Stoyanova;Matthew T. Brown
Matthew T. Brown in OpenAIREAndrew E. Welchman;
Natasha Walker;Andrew E. Welchman
Andrew E. Welchman in OpenAIREAlexis Willett;
Alexis Willett
Alexis Willett in OpenAIRESymon M. Kariuki;
Symon M. Kariuki
Symon M. Kariuki in OpenAIREAnthony Figaji;
Dan J. Stein;Anthony Figaji
Anthony Figaji in OpenAIREAmadi O. Ihunwo;
Amadi O. Ihunwo
Amadi O. Ihunwo in OpenAIREWillie M. U. Daniels;
Willie M. U. Daniels
Willie M. U. Daniels in OpenAIRECharles R. Newton;
Charles R. Newton
Charles R. Newton in OpenAIREpmid: 35731202
pmc: PMC9217128
Working in Africa provides neuroscientists with opportunities that are not available in other continents. Populations in this region exhibit the greatest genetic diversity; they live in ecosystems with diverse flora and fauna; and they face unique stresses to brain health, including child brain health and development, due to high levels of traumatic brain injury and diseases endemic to the region. However, the neuroscience community in Africa has yet to reach its full potential. In this article we report the outcomes from a series of meetings at which the African neuroscience community came together to identify barriers and opportunities, and to discuss ways forward. This exercise resulted in the identification of six domains of distinction in African neuroscience: the diverse DNA of African populations; diverse flora, fauna and ecosystems for comparative research; child brain health and development; the impact of climate change on mental and neurological health; access to clinical populations with important conditions less prevalent in the global North; and resourcefulness in the reuse and adaption of existing technologies and resources to answer new questions. The article also outlines plans to advance the field of neuroscience in Africa in order to unlock the potential of African neuroscientists to address regional and global mental health and neurological problems.
eLife arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.80488&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert eLife arrow_drop_down Oxford University Research ArchiveArticle . 2022License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.80488&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 GermanyPublisher:eLife Sciences Publications, Ltd Funded by:EC | GlacialLegacyEC| GlacialLegacyAuthors:Kruse, Stefan;
Kruse, Stefan
Kruse, Stefan in OpenAIREHerzschuh, Ulrike;
Herzschuh, Ulrike
Herzschuh, Ulrike in OpenAIREThe biodiversity of tundra areas in northern high latitudes is threatened by invasion of forests under global warming. However, poorly understood nonlinear responses of the treeline ecotone mean the timing and extent of tundra losses are unclear, but policymakers need such information to optimize conservation efforts. Our individual-based model LAVESI, developed for the Siberian tundra-taiga ecotone, can help improve our understanding. Consequently, we simulated treeline migration trajectories until the end of the millennium, causing a loss of tundra area when advancing north. Our simulations reveal that the treeline follows climate warming with a severe, century-long time lag, which is overcompensated by infilling of stands in the long run even when temperatures cool again. Our simulations reveal that only under ambitious mitigation strategies (relative concentration pathway 2.6) will ∼30% of original tundra areas remain in the north but separated into two disjunct refugia.
eLife arrow_drop_down eLifeArticleLicense: CC BYFull-Text: https://elifesciences.org/articles/75163Data sources: SygmaElectronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information CenterPublikationsserver der Universität PotsdamArticle . 2022License: CC BYData sources: Publikationsserver der Universität Potsdamadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.75163&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert eLife arrow_drop_down eLifeArticleLicense: CC BYFull-Text: https://elifesciences.org/articles/75163Data sources: SygmaElectronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information CenterPublikationsserver der Universität PotsdamArticle . 2022License: CC BYData sources: Publikationsserver der Universität Potsdamadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.75163&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 GermanyPublisher:eLife Sciences Publications, Ltd Funded by:EC | GlacialLegacyEC| GlacialLegacyAuthors:Kruse, Stefan;
Kruse, Stefan
Kruse, Stefan in OpenAIREHerzschuh, Ulrike;
Herzschuh, Ulrike
Herzschuh, Ulrike in OpenAIREThe biodiversity of tundra areas in northern high latitudes is threatened by invasion of forests under global warming. However, poorly understood nonlinear responses of the treeline ecotone mean the timing and extent of tundra losses are unclear, but policymakers need such information to optimize conservation efforts. Our individual-based model LAVESI, developed for the Siberian tundra-taiga ecotone, can help improve our understanding. Consequently, we simulated treeline migration trajectories until the end of the millennium, causing a loss of tundra area when advancing north. Our simulations reveal that the treeline follows climate warming with a severe, century-long time lag, which is overcompensated by infilling of stands in the long run even when temperatures cool again. Our simulations reveal that only under ambitious mitigation strategies (relative concentration pathway 2.6) will ∼30% of original tundra areas remain in the north but separated into two disjunct refugia.
eLife arrow_drop_down eLifeArticleLicense: CC BYFull-Text: https://elifesciences.org/articles/75163Data sources: SygmaElectronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information CenterPublikationsserver der Universität PotsdamArticle . 2022License: CC BYData sources: Publikationsserver der Universität Potsdamadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.75163&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 9 citations 9 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert eLife arrow_drop_down eLifeArticleLicense: CC BYFull-Text: https://elifesciences.org/articles/75163Data sources: SygmaElectronic Publication Information CenterArticle . 2022Data sources: Electronic Publication Information CenterPublikationsserver der Universität PotsdamArticle . 2022License: CC BYData sources: Publikationsserver der Universität Potsdamadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.75163&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023Publisher:eLife Sciences Publications, Ltd Authors:Hui Zhen Tan;
Justin JFJ Jansen;Hui Zhen Tan
Hui Zhen Tan in OpenAIREGary A Allport;
Gary A Allport
Gary A Allport in OpenAIREKritika M Garg;
+6 AuthorsKritika M Garg
Kritika M Garg in OpenAIREHui Zhen Tan;
Justin JFJ Jansen;Hui Zhen Tan
Hui Zhen Tan in OpenAIREGary A Allport;
Gary A Allport
Gary A Allport in OpenAIREKritika M Garg;
Balaji Chattopadhyay; Martin Irestedt; Sean EH Pang; Glen Chilton;Kritika M Garg
Kritika M Garg in OpenAIREChyi Yin Gwee;
Chyi Yin Gwee
Chyi Yin Gwee in OpenAIREFrank E Rheindt;
Frank E Rheindt
Frank E Rheindt in OpenAIREUnderstanding the relative contributions of historical and anthropogenic factors to declines in genetic diversity is important for informing conservation action. Using genome-wide DNA of fresh and historic specimens, including that of two species widely thought to be extinct, we investigated fluctuations in genetic diversity and present the first complete phylogenomic tree for all nine species of the threatened shorebird genus Numenius, known as whimbrels and curlews. Most species faced sharp declines in effective population size, a proxy for genetic diversity, soon after the Last Glacial Maximum (around 20,000 years ago). These declines occurred prior to the Anthropocene and in spite of an increase in the breeding area predicted by environmental niche modeling, suggesting that they were not caused by climatic or recent anthropogenic factors. Crucially, these genetic diversity declines coincide with mass extinctions of mammalian megafauna in the Northern Hemisphere. Among other factors, the demise of ecosystem-engineering megafauna which maintained open habitats may have been detrimental for grassland and tundra-breeding Numenius shorebirds. Our work suggests that the impact of historical factors such as megafaunal extinction may have had wider repercussions on present-day population dynamics of open habitat biota than previously appreciated.
eLife arrow_drop_down Digitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2023 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
more_vert eLife arrow_drop_down Digitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2023 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.85422&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023Publisher:eLife Sciences Publications, Ltd Authors:Hui Zhen Tan;
Justin JFJ Jansen;Hui Zhen Tan
Hui Zhen Tan in OpenAIREGary A Allport;
Gary A Allport
Gary A Allport in OpenAIREKritika M Garg;
+6 AuthorsKritika M Garg
Kritika M Garg in OpenAIREHui Zhen Tan;
Justin JFJ Jansen;Hui Zhen Tan
Hui Zhen Tan in OpenAIREGary A Allport;
Gary A Allport
Gary A Allport in OpenAIREKritika M Garg;
Balaji Chattopadhyay; Martin Irestedt; Sean EH Pang; Glen Chilton;Kritika M Garg
Kritika M Garg in OpenAIREChyi Yin Gwee;
Chyi Yin Gwee
Chyi Yin Gwee in OpenAIREFrank E Rheindt;
Frank E Rheindt
Frank E Rheindt in OpenAIREUnderstanding the relative contributions of historical and anthropogenic factors to declines in genetic diversity is important for informing conservation action. Using genome-wide DNA of fresh and historic specimens, including that of two species widely thought to be extinct, we investigated fluctuations in genetic diversity and present the first complete phylogenomic tree for all nine species of the threatened shorebird genus Numenius, known as whimbrels and curlews. Most species faced sharp declines in effective population size, a proxy for genetic diversity, soon after the Last Glacial Maximum (around 20,000 years ago). These declines occurred prior to the Anthropocene and in spite of an increase in the breeding area predicted by environmental niche modeling, suggesting that they were not caused by climatic or recent anthropogenic factors. Crucially, these genetic diversity declines coincide with mass extinctions of mammalian megafauna in the Northern Hemisphere. Among other factors, the demise of ecosystem-engineering megafauna which maintained open habitats may have been detrimental for grassland and tundra-breeding Numenius shorebirds. Our work suggests that the impact of historical factors such as megafaunal extinction may have had wider repercussions on present-day population dynamics of open habitat biota than previously appreciated.
eLife arrow_drop_down Digitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2023 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.85422&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!
more_vert eLife arrow_drop_down Digitala Vetenskapliga Arkivet - Academic Archive On-lineArticle . 2023 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.85422&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United Kingdom, Germany, France, FrancePublisher:eLife Sciences Publications, Ltd Publicly fundedFunded by:DFGDFGAuthors:Roshan Prakash Rane;
Evert Ferdinand de Man;Roshan Prakash Rane
Roshan Prakash Rane in OpenAIREJiHoon Kim;
JiHoon Kim
JiHoon Kim in OpenAIREKai Görgen;
+28 AuthorsKai Görgen
Kai Görgen in OpenAIRERoshan Prakash Rane;
Evert Ferdinand de Man;Roshan Prakash Rane
Roshan Prakash Rane in OpenAIREJiHoon Kim;
JiHoon Kim
JiHoon Kim in OpenAIREKai Görgen;
Kai Görgen
Kai Görgen in OpenAIREMira Tschorn;
Mira Tschorn
Mira Tschorn in OpenAIREMichael A Rapp;
Tobias Banaschewski;Michael A Rapp
Michael A Rapp in OpenAIREArun LW Bokde;
Arun LW Bokde
Arun LW Bokde in OpenAIRESylvane Desrivieres;
Herta Flor; Antoine Grigis; Hugh Garavan;Sylvane Desrivieres
Sylvane Desrivieres in OpenAIREPenny A Gowland;
Penny A Gowland
Penny A Gowland in OpenAIRERüdiger Brühl;
Jean-Luc Martinot; Marie-Laure Paillere Martinot;Rüdiger Brühl
Rüdiger Brühl in OpenAIREEric Artiges;
Eric Artiges
Eric Artiges in OpenAIREFrauke Nees;
Frauke Nees
Frauke Nees in OpenAIREDimitri Papadopoulos Orfanos;
Herve Lemaitre; Tomas Paus; Luise Poustka;Dimitri Papadopoulos Orfanos
Dimitri Papadopoulos Orfanos in OpenAIREJuliane Fröhner;
Juliane Fröhner
Juliane Fröhner in OpenAIRELauren Robinson;
Lauren Robinson
Lauren Robinson in OpenAIREMichael N Smolka;
Jeanne Winterer; Robert Whelan;Michael N Smolka
Michael N Smolka in OpenAIREGunter Schumann;
Gunter Schumann
Gunter Schumann in OpenAIREHenrik Walter;
Henrik Walter
Henrik Walter in OpenAIREAndreas Heinz;
Andreas Heinz
Andreas Heinz in OpenAIREKerstin Ritter;
IMAGEN consortium;Kerstin Ritter
Kerstin Ritter in OpenAIREAlcohol misuse during adolescence (AAM) has been associated with disruptive development of adolescent brains. In this longitudinal machine learning (ML) study, we could predict AAM significantly from brain structure (T1-weighted imaging and DTI) with accuracies of 73 -78% in the IMAGEN dataset (n∼1182). Our results not only show that structural differences in brain can predict AAM, but also suggests that such differences might precede AAM behavior in the data. We predicted 10 phenotypes of AAM at age 22 using brain MRI features at ages 14, 19, and 22. Binge drinking was found to be the most predictable phenotype. The most informative brain features were located in the ventricular CSF, and in white matter tracts of the corpus callosum, internal capsule, and brain stem. In the cortex, they were spread across the occipital, frontal, and temporal lobes and in the cingulate cortex. We also experimented with four different ML models and several confound control techniques. Support Vector Machine (SVM) with rbf kernel and Gradient Boosting consistently performed better than the linear models, linear SVM and Logistic Regression. Our study also demonstrates how the choice of the predicted phenotype, ML model, and confound correction technique are all crucial decisions in an explorative ML study analyzing psychiatric disorders with small effect sizes such as AAM.
eLife arrow_drop_down Göttingen Research Online PublicationsArticle . 2022License: CC BYData sources: Göttingen Research Online PublicationsKing's College, London: Research PortalArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)Publikationsserver der Universität PotsdamArticle . 2022License: CC BYData sources: Publikationsserver der Universität Potsdamadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.77545&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 14 citations 14 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert eLife arrow_drop_down Göttingen Research Online PublicationsArticle . 2022License: CC BYData sources: Göttingen Research Online PublicationsKing's College, London: Research PortalArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)Publikationsserver der Universität PotsdamArticle . 2022License: CC BYData sources: Publikationsserver der Universität Potsdamadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.77545&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2022 United Kingdom, Germany, France, FrancePublisher:eLife Sciences Publications, Ltd Publicly fundedFunded by:DFGDFGAuthors:Roshan Prakash Rane;
Evert Ferdinand de Man;Roshan Prakash Rane
Roshan Prakash Rane in OpenAIREJiHoon Kim;
JiHoon Kim
JiHoon Kim in OpenAIREKai Görgen;
+28 AuthorsKai Görgen
Kai Görgen in OpenAIRERoshan Prakash Rane;
Evert Ferdinand de Man;Roshan Prakash Rane
Roshan Prakash Rane in OpenAIREJiHoon Kim;
JiHoon Kim
JiHoon Kim in OpenAIREKai Görgen;
Kai Görgen
Kai Görgen in OpenAIREMira Tschorn;
Mira Tschorn
Mira Tschorn in OpenAIREMichael A Rapp;
Tobias Banaschewski;Michael A Rapp
Michael A Rapp in OpenAIREArun LW Bokde;
Arun LW Bokde
Arun LW Bokde in OpenAIRESylvane Desrivieres;
Herta Flor; Antoine Grigis; Hugh Garavan;Sylvane Desrivieres
Sylvane Desrivieres in OpenAIREPenny A Gowland;
Penny A Gowland
Penny A Gowland in OpenAIRERüdiger Brühl;
Jean-Luc Martinot; Marie-Laure Paillere Martinot;Rüdiger Brühl
Rüdiger Brühl in OpenAIREEric Artiges;
Eric Artiges
Eric Artiges in OpenAIREFrauke Nees;
Frauke Nees
Frauke Nees in OpenAIREDimitri Papadopoulos Orfanos;
Herve Lemaitre; Tomas Paus; Luise Poustka;Dimitri Papadopoulos Orfanos
Dimitri Papadopoulos Orfanos in OpenAIREJuliane Fröhner;
Juliane Fröhner
Juliane Fröhner in OpenAIRELauren Robinson;
Lauren Robinson
Lauren Robinson in OpenAIREMichael N Smolka;
Jeanne Winterer; Robert Whelan;Michael N Smolka
Michael N Smolka in OpenAIREGunter Schumann;
Gunter Schumann
Gunter Schumann in OpenAIREHenrik Walter;
Henrik Walter
Henrik Walter in OpenAIREAndreas Heinz;
Andreas Heinz
Andreas Heinz in OpenAIREKerstin Ritter;
IMAGEN consortium;Kerstin Ritter
Kerstin Ritter in OpenAIREAlcohol misuse during adolescence (AAM) has been associated with disruptive development of adolescent brains. In this longitudinal machine learning (ML) study, we could predict AAM significantly from brain structure (T1-weighted imaging and DTI) with accuracies of 73 -78% in the IMAGEN dataset (n∼1182). Our results not only show that structural differences in brain can predict AAM, but also suggests that such differences might precede AAM behavior in the data. We predicted 10 phenotypes of AAM at age 22 using brain MRI features at ages 14, 19, and 22. Binge drinking was found to be the most predictable phenotype. The most informative brain features were located in the ventricular CSF, and in white matter tracts of the corpus callosum, internal capsule, and brain stem. In the cortex, they were spread across the occipital, frontal, and temporal lobes and in the cingulate cortex. We also experimented with four different ML models and several confound control techniques. Support Vector Machine (SVM) with rbf kernel and Gradient Boosting consistently performed better than the linear models, linear SVM and Logistic Regression. Our study also demonstrates how the choice of the predicted phenotype, ML model, and confound correction technique are all crucial decisions in an explorative ML study analyzing psychiatric disorders with small effect sizes such as AAM.
eLife arrow_drop_down Göttingen Research Online PublicationsArticle . 2022License: CC BYData sources: Göttingen Research Online PublicationsKing's College, London: Research PortalArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)Publikationsserver der Universität PotsdamArticle . 2022License: CC BYData sources: Publikationsserver der Universität Potsdamadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.77545&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 14 citations 14 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert eLife arrow_drop_down Göttingen Research Online PublicationsArticle . 2022License: CC BYData sources: Göttingen Research Online PublicationsKing's College, London: Research PortalArticle . 2022Data sources: Bielefeld Academic Search Engine (BASE)Publikationsserver der Universität PotsdamArticle . 2022License: CC BYData sources: Publikationsserver der Universität Potsdamadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.77545&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type , Journal 2017Publisher:eLife Sciences Publications, Ltd Funded by:DFG | Transport and Communicati..., DFGDFG| Transport and Communication Across Biological Membrans ,DFGAuthors:Niklas Klusch;
Niklas Klusch
Niklas Klusch in OpenAIREBonnie J Murphy;
Bonnie J Murphy
Bonnie J Murphy in OpenAIREDeryck J Mills;
Deryck J Mills
Deryck J Mills in OpenAIREÖzkan Yildiz;
+1 AuthorsÖzkan Yildiz
Özkan Yildiz in OpenAIRENiklas Klusch;
Niklas Klusch
Niklas Klusch in OpenAIREBonnie J Murphy;
Bonnie J Murphy
Bonnie J Murphy in OpenAIREDeryck J Mills;
Deryck J Mills
Deryck J Mills in OpenAIREÖzkan Yildiz;
Özkan Yildiz
Özkan Yildiz in OpenAIREWerner Kühlbrandt;
Werner Kühlbrandt
Werner Kühlbrandt in OpenAIREATP synthases produce ATP by rotary catalysis, powered by the electrochemical proton gradient across the membrane. Understanding this fundamental process requires an atomic model of the proton pathway. We determined the structure of an intact mitochondrial ATP synthase dimer by electron cryo-microscopy at near-atomic resolution. Charged and polar residues of the a-subunit stator define two aqueous channels, each spanning one half of the membrane. Passing through a conserved membrane-intrinsic helix hairpin, the lumenal channel protonates an acidic glutamate in the c-ring rotor. Upon ring rotation, the protonated glutamate encounters the matrix channel and deprotonates. An arginine between the two channels prevents proton leakage. The steep potential gradient over the sub-nm inter-channel distance exerts a force on the deprotonated glutamate, resulting in net directional rotation.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.33274&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 62 citations 62 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.33274&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Conference object , Other literature type , Journal 2017Publisher:eLife Sciences Publications, Ltd Funded by:DFG | Transport and Communicati..., DFGDFG| Transport and Communication Across Biological Membrans ,DFGAuthors:Niklas Klusch;
Niklas Klusch
Niklas Klusch in OpenAIREBonnie J Murphy;
Bonnie J Murphy
Bonnie J Murphy in OpenAIREDeryck J Mills;
Deryck J Mills
Deryck J Mills in OpenAIREÖzkan Yildiz;
+1 AuthorsÖzkan Yildiz
Özkan Yildiz in OpenAIRENiklas Klusch;
Niklas Klusch
Niklas Klusch in OpenAIREBonnie J Murphy;
Bonnie J Murphy
Bonnie J Murphy in OpenAIREDeryck J Mills;
Deryck J Mills
Deryck J Mills in OpenAIREÖzkan Yildiz;
Özkan Yildiz
Özkan Yildiz in OpenAIREWerner Kühlbrandt;
Werner Kühlbrandt
Werner Kühlbrandt in OpenAIREATP synthases produce ATP by rotary catalysis, powered by the electrochemical proton gradient across the membrane. Understanding this fundamental process requires an atomic model of the proton pathway. We determined the structure of an intact mitochondrial ATP synthase dimer by electron cryo-microscopy at near-atomic resolution. Charged and polar residues of the a-subunit stator define two aqueous channels, each spanning one half of the membrane. Passing through a conserved membrane-intrinsic helix hairpin, the lumenal channel protonates an acidic glutamate in the c-ring rotor. Upon ring rotation, the protonated glutamate encounters the matrix channel and deprotonates. An arginine between the two channels prevents proton leakage. The steep potential gradient over the sub-nm inter-channel distance exerts a force on the deprotonated glutamate, resulting in net directional rotation.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.33274&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 62 citations 62 popularity Top 10% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.33274&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2017Publisher:eLife Sciences Publications, Ltd Authors: Jillian Rowe;Jamil Harb;
Jamil Harb;Jamil Harb
Jamil Harb in OpenAIREDavid R. Nelson;
+13 AuthorsDavid R. Nelson
David R. Nelson in OpenAIREJillian Rowe;Jamil Harb;
Jamil Harb;Jamil Harb
Jamil Harb in OpenAIREDavid R. Nelson;
Glenn L. Butterfoss; Alisdair R. Fernie;David R. Nelson
David R. Nelson in OpenAIREAshish Jaiswal;
Matthew J. O'Connor;Ashish Jaiswal
Ashish Jaiswal in OpenAIREKhaled M. Hazzouri;
Kristin C. Gunsalus; Kristin C. Gunsalus;Khaled M. Hazzouri
Khaled M. Hazzouri in OpenAIREBasel Khraiwesh;
Basel Khraiwesh
Basel Khraiwesh in OpenAIREAmphun Chaiboonchoe;
Nizar Drou;Amphun Chaiboonchoe
Amphun Chaiboonchoe in OpenAIREKourosh Salehi-Ashtiani;
Kourosh Salehi-Ashtiani
Kourosh Salehi-Ashtiani in OpenAIREWeiqi Fu;
Weiqi Fu
Weiqi Fu in OpenAIRESaleh Alseekh;
Saleh Alseekh
Saleh Alseekh in OpenAIRETo investigate the phenomic and genomic traits that allow green algae to survive in deserts, we characterized a ubiquitous species, Chloroidium sp. UTEX 3007, which we isolated from multiple locations in the United Arab Emirates (UAE). Metabolomic analyses of Chloroidium sp. UTEX 3007 indicated that the alga accumulates a broad range of carbon sources, including several desiccation tolerance-promoting sugars and unusually large stores of palmitate. Growth assays revealed capacities to grow in salinities from zero to 60 g/L and to grow heterotrophically on >40 distinct carbon sources. Assembly and annotation of genomic reads yielded a 52.5 Mbp genome with 8153 functionally annotated genes. Comparison with other sequenced green algae revealed unique protein families involved in osmotic stress tolerance and saccharide metabolism that support phenomic studies. Our results reveal the robust and flexible biology utilized by a green alga to successfully inhabit a desert coastline.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.25783&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.25783&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2017Publisher:eLife Sciences Publications, Ltd Authors: Jillian Rowe;Jamil Harb;
Jamil Harb;Jamil Harb
Jamil Harb in OpenAIREDavid R. Nelson;
+13 AuthorsDavid R. Nelson
David R. Nelson in OpenAIREJillian Rowe;Jamil Harb;
Jamil Harb;Jamil Harb
Jamil Harb in OpenAIREDavid R. Nelson;
Glenn L. Butterfoss; Alisdair R. Fernie;David R. Nelson
David R. Nelson in OpenAIREAshish Jaiswal;
Matthew J. O'Connor;Ashish Jaiswal
Ashish Jaiswal in OpenAIREKhaled M. Hazzouri;
Kristin C. Gunsalus; Kristin C. Gunsalus;Khaled M. Hazzouri
Khaled M. Hazzouri in OpenAIREBasel Khraiwesh;
Basel Khraiwesh
Basel Khraiwesh in OpenAIREAmphun Chaiboonchoe;
Nizar Drou;Amphun Chaiboonchoe
Amphun Chaiboonchoe in OpenAIREKourosh Salehi-Ashtiani;
Kourosh Salehi-Ashtiani
Kourosh Salehi-Ashtiani in OpenAIREWeiqi Fu;
Weiqi Fu
Weiqi Fu in OpenAIRESaleh Alseekh;
Saleh Alseekh
Saleh Alseekh in OpenAIRETo investigate the phenomic and genomic traits that allow green algae to survive in deserts, we characterized a ubiquitous species, Chloroidium sp. UTEX 3007, which we isolated from multiple locations in the United Arab Emirates (UAE). Metabolomic analyses of Chloroidium sp. UTEX 3007 indicated that the alga accumulates a broad range of carbon sources, including several desiccation tolerance-promoting sugars and unusually large stores of palmitate. Growth assays revealed capacities to grow in salinities from zero to 60 g/L and to grow heterotrophically on >40 distinct carbon sources. Assembly and annotation of genomic reads yielded a 52.5 Mbp genome with 8153 functionally annotated genes. Comparison with other sequenced green algae revealed unique protein families involved in osmotic stress tolerance and saccharide metabolism that support phenomic studies. Our results reveal the robust and flexible biology utilized by a green alga to successfully inhabit a desert coastline.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2018Embargo end date: 12 Nov 2018 Germany, SwitzerlandPublisher:eLife Sciences Publications, Ltd Funded by:DFG | Taxon-Omics: New approach...DFG| Taxon-Omics: New approaches for discovering and naming biodiversityAuthors:Constantin M Zohner;
Lidong Mo;Constantin M Zohner
Constantin M Zohner in OpenAIRESusanne S Renner;
Susanne S Renner
Susanne S Renner in OpenAIREThe temporal overlap of phenological stages, phenological synchrony, crucially influences ecosystem functioning. For flowering, among-individual synchrony influences gene flow. For leaf-out, it affects interactions with herbivores and competing plants. If individuals differ in their reaction to the ongoing change in global climate, this should affect population-level synchrony. Here, we use climate-manipulation experiments, Pan-European long-term (>15 years) observations, and common garden monitoring data on up to 72 woody and herbaceous species to study the effects of increasing temperatures on the extent of leaf-out and flowering synchrony within populations. Warmer temperatures reduce in situ leaf-out and flowering synchrony by up to 55%, and experiments on European beech provide a mechanism for how individual differences in day-length and/or chilling sensitivity may explain this finding. The rapid loss of reproductive and vegetative synchrony in European plants predicts changes in their gene flow and trophic interactions, but community-wide consequences remain largely unknown.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.40214&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 59 citations 59 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.40214&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2018Embargo end date: 12 Nov 2018 Germany, SwitzerlandPublisher:eLife Sciences Publications, Ltd Funded by:DFG | Taxon-Omics: New approach...DFG| Taxon-Omics: New approaches for discovering and naming biodiversityAuthors:Constantin M Zohner;
Lidong Mo;Constantin M Zohner
Constantin M Zohner in OpenAIRESusanne S Renner;
Susanne S Renner
Susanne S Renner in OpenAIREThe temporal overlap of phenological stages, phenological synchrony, crucially influences ecosystem functioning. For flowering, among-individual synchrony influences gene flow. For leaf-out, it affects interactions with herbivores and competing plants. If individuals differ in their reaction to the ongoing change in global climate, this should affect population-level synchrony. Here, we use climate-manipulation experiments, Pan-European long-term (>15 years) observations, and common garden monitoring data on up to 72 woody and herbaceous species to study the effects of increasing temperatures on the extent of leaf-out and flowering synchrony within populations. Warmer temperatures reduce in situ leaf-out and flowering synchrony by up to 55%, and experiments on European beech provide a mechanism for how individual differences in day-length and/or chilling sensitivity may explain this finding. The rapid loss of reproductive and vegetative synchrony in European plants predicts changes in their gene flow and trophic interactions, but community-wide consequences remain largely unknown.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.40214&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 59 citations 59 popularity Top 1% influence Top 10% impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.40214&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2020 Germany, United StatesPublisher:eLife Sciences Publications, Ltd Funded by:NIH | Functional mapping of mam..., NIH | Notch-dependent microcirc..., NIH | The neural circuits under... +1 projectsNIH| Functional mapping of mammalian neural circuits ,NIH| Notch-dependent microcircuit regulation of alcohol reward memory ,NIH| The neural circuits underlying gustatory perception in flies ,NIH| Target selection for visually guided actionsAuthors:Kristin M Scaplen;
Mustafa Talay; Kavin M Nunez;Kristin M Scaplen
Kristin M Scaplen in OpenAIRESarah Salamon;
+5 AuthorsSarah Salamon
Sarah Salamon in OpenAIREKristin M Scaplen;
Mustafa Talay; Kavin M Nunez;Kristin M Scaplen
Kristin M Scaplen in OpenAIRESarah Salamon;
Amanda G Waterman;Sarah Salamon
Sarah Salamon in OpenAIRESydney Gang;
Sophia L Song;Sydney Gang
Sydney Gang in OpenAIREGilad Barnea;
Gilad Barnea
Gilad Barnea in OpenAIREKarla R Kaun;
Karla R Kaun
Karla R Kaun in OpenAIREA powerful feature of adaptive memory is its inherent flexibility. Alcohol and other addictive substances can remold neural circuits important for memory to reduce this flexibility. However, the mechanism through which pertinent circuits are selected and shaped remains unclear. We show that circuits required for alcohol-associated preference shift from population level dopaminergic activation to select dopamine neurons that predict behavioral choice inDrosophila melanogaster. During memory expression, subsets of dopamine neurons directly and indirectly modulate the activity of interconnected glutamatergic and cholinergic mushroom body output neurons (MBON). Transsynaptic tracing of neurons important for memory expression revealed a convergent center of memory consolidation within the mushroom body (MB) implicated in arousal, and a structure outside the MB implicated in integration of naïve and learned responses. These findings provide a circuit framework through which dopamine neuronal activation shifts from reward delivery to cue onset, and provide insight into the maladaptive nature of memory.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.48730&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 33 citations 33 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.48730&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Journal 2020 Germany, United StatesPublisher:eLife Sciences Publications, Ltd Funded by:NIH | Functional mapping of mam..., NIH | Notch-dependent microcirc..., NIH | The neural circuits under... +1 projectsNIH| Functional mapping of mammalian neural circuits ,NIH| Notch-dependent microcircuit regulation of alcohol reward memory ,NIH| The neural circuits underlying gustatory perception in flies ,NIH| Target selection for visually guided actionsAuthors:Kristin M Scaplen;
Mustafa Talay; Kavin M Nunez;Kristin M Scaplen
Kristin M Scaplen in OpenAIRESarah Salamon;
+5 AuthorsSarah Salamon
Sarah Salamon in OpenAIREKristin M Scaplen;
Mustafa Talay; Kavin M Nunez;Kristin M Scaplen
Kristin M Scaplen in OpenAIRESarah Salamon;
Amanda G Waterman;Sarah Salamon
Sarah Salamon in OpenAIRESydney Gang;
Sophia L Song;Sydney Gang
Sydney Gang in OpenAIREGilad Barnea;
Gilad Barnea
Gilad Barnea in OpenAIREKarla R Kaun;
Karla R Kaun
Karla R Kaun in OpenAIREA powerful feature of adaptive memory is its inherent flexibility. Alcohol and other addictive substances can remold neural circuits important for memory to reduce this flexibility. However, the mechanism through which pertinent circuits are selected and shaped remains unclear. We show that circuits required for alcohol-associated preference shift from population level dopaminergic activation to select dopamine neurons that predict behavioral choice inDrosophila melanogaster. During memory expression, subsets of dopamine neurons directly and indirectly modulate the activity of interconnected glutamatergic and cholinergic mushroom body output neurons (MBON). Transsynaptic tracing of neurons important for memory expression revealed a convergent center of memory consolidation within the mushroom body (MB) implicated in arousal, and a structure outside the MB implicated in integration of naïve and learned responses. These findings provide a circuit framework through which dopamine neuronal activation shifts from reward delivery to cue onset, and provide insight into the maladaptive nature of memory.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.48730&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 33 citations 33 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.7554/elife.48730&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu