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The hollow-fibre oxygenator is a key component of any extracorporeal circuit used to provide cardiopulmonary bypass (CPB) during open-heart surgery. Since the oxygenator is placed downstream of the pump, the energy losses over it have a direct impact on the quality of pulsatile pressure and flow waveforms. The objective of this study was to describe the effects of hydrodynamic characteristics of the oxygenator on energy transfer during pulsatile, normothermic CPB. Twenty-three adult patients scheduled for coronary bypass surgery were divided randomly into two groups, using either an oxygenator (Group 1) with a relatively high-resistance and low-compliance (2079 ± 148 dyn.s.cm-5 and 0.00348 ± 0.00071 ml.mmHg-1, respectively) or an oxygenator (Group 2) with a relatively low-resistance and high-compliance (884 ± 464 dyn.s.cm-5 and 0.01325 ± 0.00161 ml .mmHg-1, respectively). During perfusion, pre- and post-oxygenator pressures, radial artery pressure, and blood flow were recorded simultaneously. A 32% decline of mean pressure was observed in Group 1 and a 16% decline in Group 2 (p<0.0001). Another decrease by approximately 73% in mean pressure in the rest of the perfusion system was noted in both groups. The mean radial artery pressure did not differ between the groups (74 ± 6 mmHg in Group 1 and 73 ± 6 mmHg in Group 2, p=0.608). Although lower total energy transfer indices were noticed through the low-resistance oxygenator (Group 2), both oxygenators showed a decrease of the generated pump oscillatory energy of approximately 50%. Despite the differences in resistance and compliance of the hollow-fibre oxygenators used, both oxygenators cause a comparable loss of generated oscillatory energy. Exclusion of the oxygenator downstream of the pulsatile pump would improve energy transfer during CPB.

Current economic instruments aimed at climate change mitigation focus mainly on CO(2) emissions, but efficient climate mitigation needs to focus on other greenhouse gases as well as CO(2). This study investigates the distributional effects of climate change taxes on households belonging to different income and lifestyle groups; and it compares the effects of a CO(2) tax with a multiple GHG tax in the UK in terms of cost efficiency and distributional effects. Results show that a multi GHG tax is more efficient than a CO(2) tax due to lower marginal abatement costs, and that both taxes are regressive, with lower income households paying a relatively larger share of their income for the taxes than higher income households. A shift from a CO(2) tax to a GHG tax will reduce and shift the tax burden between consumption categories such as from energy-intensive products to food products. Consumers have different abilities to respond to the tax and change their behavior due to their own socio-economic attributes as well as the physical environment such as the age of the housing stock, location, and the availability of infrastructure. The housing-related carbon emissions are the largest component of the CO(2) tax payments for low income groups and arguments could be made for compensation of income losses and reduction of fuel poverty through further government intervention.

While park-people conflicts have received worldwide attention, the extent of illegal resource extraction and the relationship with communities' livelihoods has gained little attention in the literature. Thus this paper investigates the impact of socio-economic factors involved in illegal fuel wood and fodder extraction at Bardia National Park in Nepal. Household questionnaires, key-informant interviews and focus groups were conducted to identify different plant species used by households and explore the causes and mode of resource extraction in three buffer zone villages in the park. Altogether 50 different plants were identified by villagers that were used regularly for different livelihood purposes. Almost half of the respondents met their needs by illegally and regularly extracting resources from the park. Incentive schemes in the form of development projects were important but not sufficient in meeting the basic needs of households' especially for such daily items such as fuel wood and fodder. The results described in this paper showed that proximity and access to resources either in the national park, the buffer zone community forest or the government forest, and impact on the livelihoods significantly influenced the likelihood of illegal resource extraction activities. Villages that differed in terms of their location to the resource base, the provision of alternative resources and influence of these on their livelihoods showed significant differences in terms of their patterns of resource extraction and use of these resources. As resource use options, resource interest, and resource extraction patterns were different between villages and dependent on circumstances specific to villages, site-specific management strategies were necessary and more influential than the enforcement of 'one-size fits all' policies. It is suggested that park management plans should be flexible and adaptive enough to meet site-specific contexts and to endear wider support from local communities.

To review new putative mechanisms involved in the pathophysiology of a disturbed energy balance in cancer cachexia, which can lead to novel targets for clinical cachexia management. In the context of rapid developments in tumour treatment with potential systemic consequences, this article reviews recent data on energy requirements. Furthermore, we focus on new insights in brown adipose tissue (BAT) activity and reward processing in the brain in relation to the cachexia process.Nearly no new data have been published on energy requirements of cancer patients in the light of comprehensive new therapies in oncology. New developments, such as the introduction of staging with 18F-fluorodeoxyglucose PET-computed tomography scanning, led to the observation that BAT activation may contribute to impaired energy balance in cancer cachexia. Animal and human data to date provide an indication that BAT activation indeed occurs, but its quantitative impact on the degree of cachexia is controversial. The peripheral and central nervous system is known to influence satiation, with a possible role for impaired food reward processing in the brain. To date, there are limited confirmatory data, but this is an interesting new area to explore for better understanding and treating cancer-induced anorexia.The multimodal approach to counteract cancer cachexia should expand its targets to BAT and food reward processing in the brain.

Recently, in the economics literature, several papers have put forward arguments for using a declining discount rate in social-cost benefit analysis. This paper examines the impact of employing a declining discount rate on the social cost of carbon-the marginal social damage from a ton of emitted carbon. Six declining discounting schemes are implemented in the FUND 2.8 integrated assessment model, including the recent amendments to the Green Book of HM Treasury (Treasury, H.M., 2003. The Greenbook: Appraisal and Evaluation in Central Government. TSO, London). We find that using a declining schedule of discount rates increases the social cost of carbon estimate by as little as 10% or by as much as a factor of 40, depending upon the scenario selected. Although the range of plausible estimates is large, using declining discounting schemes in FUND 2.8 in most cases does not yield values at the £70/tC level suggested by UK DEFRA [Clarkson, R., Deyes, K., 2002. Estimating the social cost of carbon emissions. Government Economic Service Working Paper. HM Treasury, London]. Indeed, only at the higher end of the values of social cost of carbon found here would many climate change related policies - such as the Kyoto Protocol - pass a cost-benefit analysis. This conclusion, however, does not necessarily undermine the ethical and political economic reasons for supporting international collective action on climate change. © 2006 Elsevier Ltd. All rights reserved.

The database presents the scenario results of an exploratory research, carried out at the International Institute for Applied Systems Analysis (IIASA): the Low Energy Demand (LED) study (Grubler et al. 2018). The LED scenario explored how far transformative changes that combine technological changes, end-use efficiency, and new business models for energy service provision can lead for lowering energy demand, and how these changes could drive deep decarbonisation in the long-term. The scenario development methodology included a bottom-up analysis of how currently existing, though often embryonic, social, institutional, and technological trends could become mainstream with resulting step-changes in efficiency and resulting lowered energy demand. The bottom-up demand estimations were then further explored for their supply side and emissions and climate implications with a top-down modeling framework drawing on the Shared Socioeconomic Pathways (SSP) framework (Riahi et al. 2017). The results show that global final energy demands can be drastically reduced in 2050, to around 245 EJ/yr, or 40% lower than today, whilst significantly expanding human welfare and reducing global development inequalities. According to the knowledge of the authors, LED is the lowest long-term global energy demand scenario ever published. The LED scenario meets the 1.5°C climate target in 2100 without overshoot and keeps the global mean temperature increase below 1.5°C with a probability of more than 60%, without requiring controversial negative emission technologies, such as bioenergy with carbon capture and storage (BECCS), that figure prominently in the emission scenario literature (Rogelj et al. 2015, Anderson and Peters 2016, Creutzig et al. 2016, Smith et al. 2016). Furthermore, the beneficial impacts of the LED scenario on a range of other sustainable development goals are also shown, demonstrating that efficiency of energy services provision plays a critical role in reaching low-energy futures without compromising increased living standards in the Global South, while at the same time reducing adverse social and environmental impacts of climate mitigation strategies that focus predominantly on large-scale supply-side transformations. The research is published in a peer-reviewed article in Nature Energy (Grubler et al. 2018) with ample supplementary information. Water consumption and withdrawal data are published in Parkinson et al. (2018). The data is available for download from the LED Database. The content of the LED database and any derived analysis may only be used for non-commercial scientific publications, articles, educational purposes, figures and data tables provided that the source reference pursuant to section 'Required citation' is included and all relevant publications are correctly cited. Partial reproductions of the database content may be stored in online repositories, if this is necessary to comply with a journal's data archiving and access requirements. Such reproductions must be limited to the scope of the manuscript in question, and must include a hyperlink to the source database hosted at https://db1.ene.iiasa.ac.at/LEDDB and the download date from the source database. However, any wholesale duplication, translation, reworking, processing, arrangement, transformation, or reproduction through the internet or any other channels, of the https://db1.ene.iiasa.ac.at/LEDDEB for commercial or non-commercial purposes is not permitted without the explicit written approval of IIASA.

Background: The gut microbiota is a putative target for dietary interventions for cardio-metabolic health (CMH), including prevention of obesity, type 2 diabetes, and cardiovascular disease. This has generated considerable interest, but the actual feasibility for diet or specific foods to induce measurable, sustained and meaningful benefits for CMH risk by this route remains uncertain. Scope and approach: This report summarises an expert workshop assessing the gut microbiota as a relevant, feasible and competitive target for CMH benefits by dietary interventions. It summarises the expert presentations and overall view of participants on the current status and outlook, considering also implications for the food industry. Key findings and conclusions: Changing the gut microbiota by diet is possible, but an assessment of the impact on CMH risk is still needed, including clarifying advantages above other known dietary routes. The individual gut microbiota composition may in part determine the impact of diet and its effects on health. Therefore, future developments may identify individuals at risk and thus possible modification of the microbiota to achieve benefits in susceptible (sub) populations depending on their initial microbiota composition. Prebiotics currently appear to be the most promising ingredients; however, required doses may be relatively high and the actual role of gut microbiota needs further assessment. Overall, causal evidence linking gut microbiota interventions with CMH benefits are developing in preclinical models but are still lacking in humans. A significant research effort is needed and ongoing to determine whether potential effects can be reliably substantiated.

South Africa is likely to experience higher temperatures and less rainfall as a result of climate change. Resulting changes in regional water endowments and soil moisture will affect the productivity of cropland, leading to changes in food production and international trade patterns. High population growth elsewhere in Africa and Asia will put further pressure on natural resources and food security in South Africa. Based on four climate change scenarios from two general circulation models (CSIRO and MIROC) and two IPCC SRES emission scenarios (A1B, B1), this study assesses the potential impacts of climate change on global agriculture and explores two alternative adaptation scenarios for South Africa. The analysis uses an updated GTAP-W model, which distinguishes between rainfed and irrigated agriculture and implements water as an explicit factor of production for irrigated agriculture. For South Africa to adapt to the adverse consequences of global climate change, it would require yield improvements of more than 20 percent over baseline investments in agricultural research and development. A doubling of irrigation development, on the other hand, will not be sufficient to reverse adverse impacts from climate change in the country.