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Polydrug use is common, and might occur because certain individuals experience positive effects from several different drugs during early stages of use. This study examined individual differences in subjective responses to single oral doses of d-amphetamine, alcohol, and delta-9-tetrahydrocannabinol (THC) in healthy social drinkers. Each of these drugs produces feelings of well-being in at least some individuals, and we hypothesized that subjective responses to these drugs would be positively correlated. We also examined participants' drug responses in relation to personality traits associated with drug use. In this initial, exploratory study, 24 healthy, light drug users (12 male, 12 female), aged 21-31 years, participated in a fully within-subject, randomized, counterbalanced design with six 5.5-hour sessions in which they received d-amphetamine (20mg), alcohol (0.8 g/kg), or THC (7.5 mg), each paired with a placebo session. Participants rated the drugs' effects on both global measures (e.g. feeling a drug effect at all) and drug-specific measures. In general, participants' responses to the three drugs were unrelated. Unexpectedly, "wanting more" alcohol was inversely correlated with "wanting more" THC. Additionally, in women, but not in men, "disliking" alcohol was negatively correlated with "disliking" THC. Positive alcohol and amphetamine responses were related, but only in individuals who experienced a stimulant effect of alcohol. Finally, high trait constraint (or lack of impulsivity) was associated with lower reports of liking alcohol. No personality traits predicted responses across multiple drug types. Generally, these findings do not support the idea that certain individuals experience greater positive effects across multiple drug classes, but instead provide some evidence for a "drug of choice" model, in which individuals respond positively to certain classes of drugs that share similar subjective effects, and dislike other types of drugs.

This paper aims to provide a deeper understanding of the water-, sanitation- and hygiene (WASH)-related insecurities that people experiencing homelessness in urban areas of high-income countries (HIC) are facing, and how these insecurities are further complicated during extreme weather events. While limited recent research has looked into WASH among people experiencing homelessness in HICs, and while some work has considering the implications of climate change on WASH and health, the nexus of WASH, extreme weather events and homelessness in HICs have not been studied thus far. We conducted the first systematic scoping review of peer-reviewed literature on this nexus, which is understudied and marked by complexity, involving a range of systems and forms of impact. A total of 50 publications were included in our analysis.We found that public facilities like drinking water fountains, toilets, handwashing facilities, and showers are scarce, frequently unavailable, often pose safety and cleanliness issues, and access to non-public facilities may be cost-prohibitive for homeless populations. Consequently, people experiencing homelessness, including those sleeping rough, in encampments, or shelters, are often forced to limit drinking water consumption, forego healthy hygiene behaviours, and resort to open urination and defecation, all of which carry health risks. Extreme weather events, like heatwaves, extreme cold, heavy rain and flooding exacerbate challenges for people experiencing homelessness, further complicating their access to WASH, and reducing the ability of service providers to deliver extra relief, creating a dual WASH and health burden.Our review highlights that the Human Right to Water and Sanitation is not met for people experiencing homelessness in urban areas of high-income countries, with women emerging as one of the most vulnerable subgroups. It reveals that the impact of certain WASH issues (e.g. drinking water) on homeless populations are better understood than others (e.g. waste), and, similarly, the effects of certain extreme weather events (e.g. heatwaves) on the health and WASH conditions of people experiencing homelessness are better understood than others (e.g. flooding). Data gaps and the lack of information on limited WASH access and health circumstances of people experiencing homelessness, further minimize their representation and consequently impose obstacles to improve their situation.Based on our analysis, we established a framework which operationalizes the nexus of WASH, extreme weather events and homelessness. This framework improves our understanding of the underlying complexities at the intersection of these three issues and provides a foundation for enhanced preparedness and health-oriented planning.

CP-66,948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties. The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously). In addition, the mucosal protective activity is independent of prostaglandin synthesis. CP-66,948 inhibits gastric acid secretion in man, and its mucosal protective activity may provide additional benefits in peptic ulcer therapy.

Policies and interventions involving the built environment have become a promising opportunity for the promotion of walking as a sustainable transportation mode. Among voluminous literature, few studies were found that examined the association between the built environment and walking among the elderly in China. This study investigated the relationship between the built environment and the walking activity of the elderly based on data collected in Zhongshan Metropolitan Area, China. The results suggest that abundant sidewalks, dense bus stops, easily accessible commercial establishments, and ample green land space are potentially effective to enhance walking among the elderly, albeit to varied degrees. The compact urban form, which is considered as walkability in the western context, may not necessarily play a positive role in Zhongshan’s context. The findings provide insights into the policy-making to promote sustainable transportation modes and the design of interventions on health promotion of the elderly in China.

The Hindu Kush Himalayan (HKH) region comprises of areas which are highly vulnerable to flood risks. The region faces challenges from multiple non-climate stressors such as poverty, environmental and climate shocks, and inadequate infrastructure. Addressing these deprivations in ways that reduce vulnerability associated with a changing climate are critical for the communities that live here. This paper combines data on flood risks derived from a climate–hydrology model under two future scenarios of RCP 4.5 and 8.5, with socio-economic data from communities in the Gandak basin, to demonstrate how mainstreaming climate change impacts into decision-making for sanitation interventions can reduce socio-economic vulnerability to flooding. A Cost-effectiveness analysis of the alternative interventions for sanitation reveals that gains are substantially higher under an intervention that takes note of climatic events, both for the present and in the future. Substantial health costs and inconvenience losses that are particularly acute for women during floods can be averted by investing in climate-friendly options. Climate adaptation (SDG goal 13 on climate action) can be synergistic with the achievement of other SDGs (Goal 6 on sanitation, goal 3 on health and well-being, goal 5 on gender).

This study investigated the effectiveness of a targeted intervention program aimed at at-risk adolescents in a randomized clinical trial design (N=107). This program combined intervention methods which have been proven effective in reducing drinking in young adults, such as an expectancy challenge, cognitive behavioral skill training and brief motivational feedback. Additionally, this intervention contained the new element of discussing biological, cognitive and social risk factors for developing alcohol problems. We investigated whether this seven session program was successful in changing cognitive determinants of drinking behavior and consequently in moderating alcohol use and the development of alcohol-related problems in at-risk adolescents. The intervention was effective in changing several of the targeted cognitive determinants. However, despite the changes in these cognitive determinants of drinking, the experimental group did not show a significant difference in decrease of drinking at posttest compared with the control group. The results did not yield support for any differential long term effects of the intervention. We concluded that although the present intervention successfully changed important cognitive determinants of drinking more is needed to change subsequent drinking behavior in at-risk adolescents.

This paper analyses the role of official development assistance (ODA) in the evolution of Technological Innovation Systems (TISs) of improved cookstoves in Kenya and Rwanda. Functionally balanced TISs are central to the diffusion of new technologies and practices. We find that ODA has significantly influenced major innovation activities related to improved cookstoves in both Kenya and Rwanda over the last 30 years. However, donors’ funding has been focused mainly on the development and diffusion of technical knowledge. We find that this pattern of ODA support has not fostered balanced and effective Technology Innovation Systems, and that this has contributed to the failure to achieve widespread diffusion of improved cookstoves. We develop a quasi-evolutionary model for the long-term and systematic ODA support of innovation systems to build sustainable renewable energy TISs in developing countries.