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AbstractThe co‐occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co‐occur. There is also an indication of a gender‐dependent effect; males are more likely to use alcohol to cope with chronic pain problems than females. Recently, a new conceptualization has emerged, proposing that the negative affective component of pain drives and maintains alcohol‐related behaviors. We studied in a longitudinal fashion alterations in alcohol drinking patterns and pain thresholds in a mouse model of chronic neuropathic pain in a sex‐dependent manner. Following partial denervation (spared nerve injury [SNI]), stimulus‐evoked pain responses were measured before chronic alcohol consumption, during drinking, during a deprivation phase, and following an episode of excessive drinking. During the course of alcohol drinking, we observed pronounced sex differences in pain thresholds. Male mice showed a strong increase in pain thresholds, suggesting an analgesic effect induced by alcohol over time, an effect that was not observed in female mice. SNI mice did not differ from sham‐operated controls in baseline alcohol consumption. However, following a deprivation phase and the reintroduction of ethanol, male SNI mice but not female mice showed more pronounced excessive drinking than controls. Finally, we observed decreased central ethanol sensitivity in male SNI mice but not in females. Together with our finding, that ethanol is able to decrease a pain‐induced negative affective memory we come to following conclusion. We propose that a lower sensitivity to the intoxicating effects of alcohol together with the ability of alcohol to reduce the negative affective component of pain may explain the higher co‐occurrence of AUD in male chronic pain patients.

Abstract Like cities, many large national parks in the United States often include “urban” visitor and residential areas that mostly demand (rather than produce) energy and key urban materials. The U.S. National Park Service has committed to quantifying and reducing scopes 1 and 2 emissions by 35% and scope 3 emissions by 10% by 2020 for all parks. Current inventories however do not provide the specificity or granularity to evaluate solutions that address fundamental inefficiencies in these inventories. By quantifying and comparing the importance of different inventory sectors as well as upstream and downstream emissions in Yosemite National Park (YNP), this carbon footprint provides a case study and potential template for quantifying future emissions reductions, and for evaluating tradeoffs between them. Results indicate that visitor-related emissions comprise the largest fraction of the Yosemite carbon footprint, and that increases in annual visitation (3.43–3.90 million) coincide with and likely drive interannual increases in the magnitude of Yosemite′s extended inventory (126,000–130,000 t CO2e). Given this, it is recommended that “per visitor” efficiency be used as a metric to track progress. In this respect, YNP has annually decreased kilograms of GHG emissions per visitor from 36.58 (2008) to 32.90 (2011). We discuss opportunities for reducing this measure further.

Abstract For Solid Oxide Fuel Cells (SOFCs) to become an economically attractive energy conversion technology, suitable materials and structures which enable operation at lower temperatures, while retaining high cell performance, must be developed. Recently, the perovskite-type La 0.6 Ca 0.4 Fe 0.8 Ni 0.2 O 3 oxide has shown potential as an intermediate temperature SOFC cathode. An equivalent circuit describing the cathode polarization resistances was constructed from analyzing impedance spectra recorded at different temperatures in oxygen. A competitive electrode polarization resistance is reported for this oxygen electrode using a Ce 0.8 Gd 0.2 O 1.9 electrolyte, determined by impedance spectroscopy studies of symmetrical cells sintered at 800 °C and 1000 °C. Scanning electron microscopy (SEM) studies of the symmetrical cells revealed the absence of any reaction layer between cathode and electrolyte, and a porous electrode microstructure even when sintered at a temperature of only 800 °C. The performance of this cathode shows favorable oxygen reduction reaction (ORR) properties potentially making it an excellent choice for IT-SOFC application.

Abstract Building-integrated photovoltaics (BIPV) is a growing reality worldwide and its development involves implementing techniques to log and estimate the solar resources available. In this paper an easy methodology for the pre-classification of facades in BIPV projects has been described. This step is previous to the calculation of the complete solar potential in a building, and don't include the shape and shading factors. The proposed methodology covers the development of a new model that allows the irradiation factor (IF) to be estimated on facades with only 2 input parameters: the latitude of the place and the azimuth angle of the photovoltaic generator. The necessary tools to assess the “Energetic Efficiency Rating” for BIPV facades are provided, as an initial stage to be applied by architects and engineers.

Ethanol is the most common human teratogen, and its consumption during pregnancy can produce a wide range of abnormalities in infants known as fetal alcohol spectrum disorder (FASD). The major characteristics of FASD can be divided into: (i) growth retardation, (ii) craniofacial abnormalities, and (iii) central nervous system (CNS) dysfunction. FASD is the most common cause of nongenetic mental retardation in Western countries. Although the underlying molecular mechanisms of ethanol neurotoxicity are not completely determined, the induction of oxidative stress is believed to be one central process linked to the development of the disease. Currently, there is no known effective strategy for prevention (other than alcohol avoidance) or treatment. In the present review we will provide the state of art in the evidence for the use of antioxidants as a potential therapeutic strategy for the treatment using whole‐embryo and culture cells models of FASD. We conclude that the imbalance of the intracellular redox state contributes to the pathogenesis observed in FASD models, and we suggest that antioxidant therapy can be considered a new efficient strategy to mitigate the effects of prenatal ethanol exposure. Birth Defects Research (Part A) 103:163–177, 2015. © 2014 Wiley Periodicals, Inc.

Although recent research has demonstrated that waste orange peel (WOP) is a potentially valuable resource that can be transformed into high value products, heat generation, biomethanisation and composting might be considered the most feasible alternatives in terms of yield. This study revealed that WOP can be successfully valorised through combustion. However, a previous drying step, which generates hazardous wastewater, is required and harmful NOx are emitted with the flue gases. In contrast, a high yield of renewable methane (280LSTPCH4/kg added COD, chemical oxygen demand) and an organic amendment can be obtained through the thermophilic biomethanisation of WOP following the removal of valuable essential oils from the peel. Co-composting of WOP combined at different proportions (17-83%) with the organic fraction of municipal solid waste (OFMSW) was also demonstrated to be suitable. Moreover, a 37% reduction in odour generation was observed in co-composting of WOP compared to single composting of OFMSW.

With the spotlight on smart grid development around the world, it is critical to recognize the key factors contributing to changing power system characteristics. This is more apparent in distribution systems with the integration of renewable energy sources, energy storage, and microgrid development. Utilities are also focusing on the reliability and resiliency of the grid. These activities require distribution automation (DA) strategies that take advantage of available technologies while promoting newer solutions. It is necessary to create a roadmap for holistic DA strategies in a smarter grid. Sustainable and resilient grid development is a paradigm shift requiring a new line of thinking in the engineering, operation, and maintenance of the power system. International perspectives on DA are also addressed, with the understanding that one solution will not fit all. Integrating technical, business, and policy decisions into the challenges will generate the development of technologies, standards, and implementation of the overall solution. The challenges in the development of industry standards are also discussed. This paper explores the challenges and opportunities in the changing landscape of the distribution systems. Evolution of technologies and the business case for infrastructure investment in distribution systems are covered in another paper by the same authors.

Dietary change presents an opportunity to meet the dual challenges of non-communicable diseases and the effects of climate change in China. Based on a food survey and reviewed data sets, we linked nutrient composition and carbon footprint data by aggregating 1950 types of foods into 28 groups. Nine dietary scenarios for both men and women were modeled based on the current diet and latest National Program for Food and Nutrition. Linear uncertainty optimization was used to produce diets meeting the Chinese Dietary Reference Intakes for adults aged 18-50years while minimizing carbon footprints. The theoretical optimal diet reduced daily footprints by 46%, but this diet was unrealistic due to limited food diversity. Constrained by acceptability, the optimal diet reduced the daily carbon footprints by 7-28%, from 3495 to 2517-3252g CO2e, for men and by 5-26%, from 3075 to 2280-2917g CO2e, for women. Dietary changes for adults are capable of benefiting China in terms of the considerable footprint reduction of 53-222Mt.CO2eyear-1, when magnified based on the Chinese population, which is the largest worldwide. Seven of eight scenarios showed that reductions in meat consumption resulted in greater reductions in greenhouse gas emissions. However, dramatic reductions in meat consumption may produce smaller reductions in emissions, as the consumption of other ingredients increases to compensate for the nutrients in meat. A trade-off between poultry and other meats (beef, pork, and lamb) is usually observed, and rice, which is a popular food in China, was the largest contributor to carbon footprint reductions. Our findings suggest that changing diets for climate change mitigation and human health is possible in China, though the per capital mitigation potential is slight lower than that in developed economies of France, Spain, Sweden, and New Zealand.

Abstract Solar energy, as main energy supply that sustains life on Earth, is also an unavoidable component of the complex strategy in achieving a clean and fair energy transition and goals for sustainable development by 2030. The present work studies the potential of installing Photovoltaic Distributed Generation at Universidad Politecnica de Madrid – Ciudad Universitaria campus. To this end, the study focuses on the electricity generation, carbon reduction and economic feasibility of solar photovoltaic systems installation using and comparing two different approaches based on data input with different time resolution, simulation software and level of details. Results show that the optimal photovoltaic power that maximizes emissions savings also ensures the best economic return, and in addition coincides with the maximum solar potential of the Campus, which is about 3.3 MW. At campus level, approximately 77% of the photovoltaic electricity production would be consumed locally, which would suppose a coverage of about 40% of the total electricity consumption. Emissions savings could reach 30% and an in-depth economic analysis indicates that the project is highly profitable. These results and methodology could be used to assess the feasibility of photovoltaic systems at other universities and help entities study the solar potential of their buildings.