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description Publicationkeyboard_double_arrow_right Conference object , Article 2012 ItalyPublisher:IEEE Authors: Ottorino Veneri; Fortunato Migliardini; P. Corbo; Clemente Capasso;In this paper some preliminary experimental results on a Zebra battery based propulsion system for urban bus applications are presented. The tests were carried out using a laboratory 1:1 scale test bench, composed by a 65 kW electric drive, specifically designed for urban bus applications, supplied by two 20 kWh Zebra batteries connected in parallel. The electric power train was tested on a laboratory bench, connected through a fixed ratio gear box to a 100 kW regenerative electric brake provided with speed and torque controls, in order to evaluate the propulsion system performance in steady state operative conditions. The obtained preliminary experimental results were utilized to implement a Matlab-Simulink model of urban bus, which might be powered by the same electric propulsion system studied. Thanks to this model it was possible to evaluate the dynamic behavior of the urban bus, working on standard driving cycles, taking into account the resistant forces represented by proper vehicle/road/aerodynamic parameters. An evaluation of the expected real vehicle driving range was also estimated in different road conditions.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/esars.2012.6387489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Average influence Top 10% impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/esars.2012.6387489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Thesis 2024 United KingdomPublisher:Apollo - University of Cambridge Repository Authors: Silseth, Tobias;doi: 10.17863/cam.109687
From the British debate on the depletion of coal in 1865 to the First World Power Conference held in London in 1924, scientists, engineers, industrialists, and politicians produced new interpretations of the past, present, and future in terms of the mobilisation of energy resources. This thesis identifies an emerging ‘energy developmentalism’, which called for maximising energy use to maintain or improve a nation’s place in international competition. Energy developmentalism was not a marginal worldview confined to ‘energeticists’, but a coherent set of claims, measurements, and arguments that informed energy governance on an international scale. Rather than focusing on a single resource, energy developmentalism applied a unified schema to all energy sources, including those like solar and tidal energy that were still mostly theoretical. Drawing on sources from across Europe, while staying grounded in political changes in Britain and France, makes it possible to understand how a general formula for transforming raw materials with maximum efficiency was applied differently depending on specific political contexts. This period saw the articulation of problems like the depletion of resources, the difference between renewable and nonrenewable energy, the intermittency of renewables, the overreliance on a single source of energy, and the centrality of energy to modern economies – problems that are often associated with later periods. Scientific measurements of efficiency, horsepower, and kilowatts became operators in political debates centred on questions of national standing and progress. Even as oil became increasingly important in the world economy, the delegates at the First World Power Conference transformed a vision of a renewable energy future into one of a general expansion of energy consumption as the basis of progress. In so doing, they downplayed the continued importance of fossil fuels and equated ‘conservation’ with the fullest possible use of all energy sources, renewable or not.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.109687&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.109687&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020Embargo end date: 14 Feb 2020 United KingdomPublisher:Wilmington Publishing Ltd. Authors: Schulz, Christopher;doi: 10.17863/cam.49244
ON 16 NOVEMBER 2000, the final report of the World Commission on Dams (WCD) was launched in London, in the presence of South Africa’s former president Nelson Mandela. This represented a remarkable milestone in the history of dam policy and politics. During its two-year existence, WCD had conducted the most extensive review of research and evidence regarding the planning, impacts, and management of large dams. It had engaged with numerous stakeholders around the globe. It also made comprehensive recommendations about how to improve dam planning and management.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.49244&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!
visibility 17visibility views 17 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.49244&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 FrancePublisher:Springer Science and Business Media LLC Authors: Kintché, Kokou; Guibert, Hervé; Bonfoh, Bassirou; Tittonell, Pablo;Using 40-year experiment data from a mono-modal rainfall area of northern Togo, we analyzed soil fertility dynamics when 2 and 3-year fallows were alternated with 3-year rotation of groundnut, cotton and sorghum. The control treatment consisted to continuous cultivate the soil in a rotation of groundnut/cotton/sorghum without fallow periods. For each rotation, two fertilisation rates were applied: no fertilisation and mineral fertiliser application during the cropping and/or the fallow periods. Yields of unfertilised crops, which averaged 1 t ha-1 during the first years of cultivation, were often nil in the long-term. In the long-term, yields of fertilised cotton and sorghum decreased by 32 and 50 %, respectively compared to the average of 2.4 and 1.6 t ha-1 obtained during the first decade of cultivation. The long-term decline in crop productivity was mitigated when fallow periods were alternated with cropping periods, and consequently there was partial compensation in terms of production for the unproductive fallowed plots. Long-term yields of fertilised cotton and sorghum in the periodically fallowed plots were 40 and 50 % higher than those in continuously cropped plots, respectively; they were 90 and 60 % higher than those in continuously cropped plots without fertilisation. Like for crop productivity, soil C, N and exchangeable Ca and Mg decreased less in periodically fallowed plots than in continuously cropped plots. The limited soil C decline when fallows were alternated with crops appears to be the consequence of no-tillage period rather than the effect of the highest C inputs to the soil.
Nutrient Cycling in ... arrow_drop_down Nutrient Cycling in AgroecosystemsArticle . 2015Data sources: DANS (Data Archiving and Networked Services)Nutrient Cycling in AgroecosystemsArticle . 2015 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10705-015-9681-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert Nutrient Cycling in ... arrow_drop_down Nutrient Cycling in AgroecosystemsArticle . 2015Data sources: DANS (Data Archiving and Networked Services)Nutrient Cycling in AgroecosystemsArticle . 2015 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10705-015-9681-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2002 Italy, United KingdomPublisher:Kluwer Academic, Boston , Paesi Bassi Korhola, A.; Sorvari, S.; Rautio, M.; Appleby, P.G.; Dearing, J.A.; Hu, Y.; Rose, N.; Lami, A.; Cameron, N.G.;Responses to recent climatic changes in the sediment of subarctic Lake Saanajärvi in northwestern Finnish Lapland are studied by comparison of various biological and sedimentological proxies with the 200-year long climate record, specifically reconstructed for the site using a data-set of European-wide meteorological data. The multi-proxy evidence of simultaneously changing diatom, Cladocera, and chrysophyte assemblages along with the increased rates of organic matter accumulation and pigment concentrations suggest that the lake has undergone a distinct typological change starting from the turn of the 20th century. This change, indicating an increase in lake productivity, parallels a pronounced rise in the meteorologically reconstructed mean annual and summer temperatures in the region between ca. 1850 and 1930's. We postulate that, during the Little Ice Age, the lake was not, or was only weakly, thermally stratified during summer, whereas the subsequent increase in air and hence epilimnetic water temperatures resulted in the development of the present summer stratification. The increased thermal stability of the lake created more suitable conditions for the growth of phyto- and zooplankton and changed the overall primary production from benthos to plankton. Mineral magnetic and carbonaceous particle records suggest long-distance pollution, particularly since the 1920's, yet the observed changes in lake biota and productivity can hardly be explained by this very minor background pollution; the 20th century species configurations are typical of neutral waters and do not indicate any response to pollution.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1023/a:1020371902214&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1023/a:1020371902214&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 ItalyPublisher:Hindawi Limited Authors: Yagmur Atak; C. Ozgur Colpan; Adolfo Iulianelli;doi: 10.1002/er.7186
The most widely used process for hydrogen production is steam methane reforming. It can be carried out using a membrane reactor in which simultaneous hydrogen production and purification occur. Mathematical modeling of these reactors plays a key role in the selection of the design and operating parameters that yield high performance for the reactor. This review study discusses, synthesizes, and compares different mathematical modeling studies on the packed bed membrane reactors for hydrogen production from methane found in the literature. Different approaches used in these modeling studies for the hydrogen permeation steps, reaction kinetic expressions, phases involved (pseudo-homogeneous and heterogeneous), and spatial dimensions (one, two, and three dimensional) are given.
CNR ExploRA arrow_drop_down International Journal of Energy ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/er.7186&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert CNR ExploRA arrow_drop_down International Journal of Energy ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/er.7186&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Article 2011 ItalyPublisher:IEEE Authors: Aliberti; Massimo;Intention of this work is to investigate the opportunity and feasibility of energy efficient networking in Home and Building automation protocols. Wired HBAS have traditionally devoted a relatively little attention to this point, especially if compared to wireless networks. This paper will try to address the issue by evaluating the introduction of power state switching in a real scenario and proposing the concept of functional and spatial adjacency among packets.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icce.2011.5722802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!
visibility 1visibility views 1 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icce.2011.5722802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2019 PortugalPublisher:Elsevier BV Funded by:FCT | Laboratory for Robotics a..., FCT | SusCity, FCT | Associate Laboratory of ...FCT| Laboratory for Robotics and Engineering Systems ,FCT| SusCity ,FCT| Associate Laboratory of Energy, Transports and AeronauticsRoberto A. Varella; Gonçalo Duarte; Gonçalo Duarte; Marta V. Faria; Patrícia Baptista; Tiago L. Farias;Abstract This work assesses the impacts of aggressive driving behavior on pollutants emissions and energy consumption at a city level. Furthermore, it performs an economic analysis considering the potential avoided emissions and fuel savings and discusses potential policy measures to address this topic. The results showed that aggressive driving significantly impacts energy consumption and emissions, with energy consumption increasing by more than ∼200% and emissions by 330% for aggressive driving compared to non-aggressive driving (in MJ/km and in g/km, respectively). This increment was found to be even higher for diesel vehicles than for gasoline vehicles. On the contrary, gasoline vehicles showed higher percentages of increase for most emissions (CO, NOx and NO). Results also revealed that aggressive driving impacts are higher for local streets when examining the city level. Moreover, the economic analysis showed that significant cost reductions may be achieved by avoiding aggressive driving, reaching up to 52.5 k€ on a daily basis. In conclusion, this study is of particular relevance to policy makers and urban planners, enabling to obtain a comprehensive overview of the impacts of aggressive driving behaviors at a city level and providing new insights to perform further developments and to assess the feasibility of the implementation of policy measures.
Repositório Científi... arrow_drop_down Repositório Científico do Instituto Politécnico de LisboaArticle . 2019Energy Research & Social ScienceArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.erss.2018.09.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 25 citations 25 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 88visibility views 88 download downloads 52 Powered bymore_vert Repositório Científi... arrow_drop_down Repositório Científico do Instituto Politécnico de LisboaArticle . 2019Energy Research & Social ScienceArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.erss.2018.09.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2013Publisher:Ovid Technologies (Wolters Kluwer Health) Authors: Mark P. Jensen; Johannes Vlaeyen; Warren R. Nielson; Petra A. Karsdorp;pmid: 23247005
Activity pacing (AP) is a concept that is central to many chronic pain theories and treatments, yet there remains confusion regarding its definition and effects.To review the current knowledge concerning AP and integrate this knowledge in a manner that allows for a clear definition and useful directions for future research.A narrative review of the major theoretical approaches to AP and of the empirical evidence regarding the effects of AP interventions, followed by an integrative discussion.The concept of AP is derived from 2 main traditions: operant and energy conservation. Although there are common elements across these traditions, significant conceptual and practical differences exist, which has led to confusion. Little empirical evidence exists concerning the efficacy of AP as a treatment for chronic pain.Future research on AP should be based on a clear theoretical foundation, consider the context in which the AP behavior occurs and the type of pacing problem ("underactivity" vs. "overactivity"), and should examine the impact of AP treatment on multiple clinical outcomes. We provide a provisional definition of AP and specific recommendations that we believe will move the field forward.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/ajp.0b013e3182608561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 115 citations 115 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/ajp.0b013e3182608561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014Publisher:Elsevier BV A. Charlotte P. Sewing; Viola Caretti; Tonny Lagerweij; Pepijn Schellen; Marc H.A. Jansen; Dannis G. van Vuurden; Sander Idema; Carla F.M. Molthoff; W. Peter Vandertop; Gertjan J.L. Kaspers; David P. Noske; Esther Hulleman;pmid: 25263805
Systemic delivery of therapeutic agents remains ineffective against diffuse intrinsic pontine glioma (DIPG), possibly due to an intact blood-brain-barrier (BBB) and to dose-limiting toxicity of systemic chemotherapeutic agents. Convection-enhanced delivery (CED) into the brainstem may provide an effective local delivery alternative for DIPG patients.The aim of this study is to develop a method to perform CED into the murine brainstem and to test this method using the chemotherapeutic agent carmustine (BiCNU). To this end, a newly designed murine CED catheter was tested in vitro and in vivo. After determination of safety and distribution, mice bearing VUMC-DIPG-3 and E98FM-DIPG brainstem tumors were treated with carmustine dissolved in DW 5% or carmustine dissolved in 10% ethanol.Our results show that CED into the murine brainstem is feasible and well tolerated by mice with and without brainstem tumors. CED of carmustine dissolved in 5% DW increased median survival of mice with VUMC-DIPG-3 and E98FM-DIPG tumors with 35% and 25% respectively. Dissolving carmustine in 10% ethanol further improved survival to 45% in mice with E98FM-DIPG tumors.Since genetically engineered and primary DIPG models are currently only available in mice, murine CED studies have clear advantages over CED studies in other animals.CED in the murine brainstem can be performed safely, is well tolerated and can be used to study efficacy of chemotherapeutic agents orthotopically. These results set the foundation for more CED studies in murine DIPG models.
Journal of Neuroscie... arrow_drop_down Journal of Neuroscience MethodsArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Journal of Neuroscience MethodsArticle . 2014 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jneumeth.2014.09.020&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 23 citations 23 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Journal of Neuroscie... arrow_drop_down Journal of Neuroscience MethodsArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Journal of Neuroscience MethodsArticle . 2014 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jneumeth.2014.09.020&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Conference object , Article 2012 ItalyPublisher:IEEE Authors: Ottorino Veneri; Fortunato Migliardini; P. Corbo; Clemente Capasso;In this paper some preliminary experimental results on a Zebra battery based propulsion system for urban bus applications are presented. The tests were carried out using a laboratory 1:1 scale test bench, composed by a 65 kW electric drive, specifically designed for urban bus applications, supplied by two 20 kWh Zebra batteries connected in parallel. The electric power train was tested on a laboratory bench, connected through a fixed ratio gear box to a 100 kW regenerative electric brake provided with speed and torque controls, in order to evaluate the propulsion system performance in steady state operative conditions. The obtained preliminary experimental results were utilized to implement a Matlab-Simulink model of urban bus, which might be powered by the same electric propulsion system studied. Thanks to this model it was possible to evaluate the dynamic behavior of the urban bus, working on standard driving cycles, taking into account the resistant forces represented by proper vehicle/road/aerodynamic parameters. An evaluation of the expected real vehicle driving range was also estimated in different road conditions.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu10 citations 10 popularity Average influence Top 10% impulse Average Powered by BIP!
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Thesis 2024 United KingdomPublisher:Apollo - University of Cambridge Repository Authors: Silseth, Tobias;doi: 10.17863/cam.109687
From the British debate on the depletion of coal in 1865 to the First World Power Conference held in London in 1924, scientists, engineers, industrialists, and politicians produced new interpretations of the past, present, and future in terms of the mobilisation of energy resources. This thesis identifies an emerging ‘energy developmentalism’, which called for maximising energy use to maintain or improve a nation’s place in international competition. Energy developmentalism was not a marginal worldview confined to ‘energeticists’, but a coherent set of claims, measurements, and arguments that informed energy governance on an international scale. Rather than focusing on a single resource, energy developmentalism applied a unified schema to all energy sources, including those like solar and tidal energy that were still mostly theoretical. Drawing on sources from across Europe, while staying grounded in political changes in Britain and France, makes it possible to understand how a general formula for transforming raw materials with maximum efficiency was applied differently depending on specific political contexts. This period saw the articulation of problems like the depletion of resources, the difference between renewable and nonrenewable energy, the intermittency of renewables, the overreliance on a single source of energy, and the centrality of energy to modern economies – problems that are often associated with later periods. Scientific measurements of efficiency, horsepower, and kilowatts became operators in political debates centred on questions of national standing and progress. Even as oil became increasingly important in the world economy, the delegates at the First World Power Conference transformed a vision of a renewable energy future into one of a general expansion of energy consumption as the basis of progress. In so doing, they downplayed the continued importance of fossil fuels and equated ‘conservation’ with the fullest possible use of all energy sources, renewable or not.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.109687&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.109687&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020Embargo end date: 14 Feb 2020 United KingdomPublisher:Wilmington Publishing Ltd. Authors: Schulz, Christopher;doi: 10.17863/cam.49244
ON 16 NOVEMBER 2000, the final report of the World Commission on Dams (WCD) was launched in London, in the presence of South Africa’s former president Nelson Mandela. This represented a remarkable milestone in the history of dam policy and politics. During its two-year existence, WCD had conducted the most extensive review of research and evidence regarding the planning, impacts, and management of large dams. It had engaged with numerous stakeholders around the globe. It also made comprehensive recommendations about how to improve dam planning and management.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.49244&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!
visibility 17visibility views 17 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.49244&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2015 FrancePublisher:Springer Science and Business Media LLC Authors: Kintché, Kokou; Guibert, Hervé; Bonfoh, Bassirou; Tittonell, Pablo;Using 40-year experiment data from a mono-modal rainfall area of northern Togo, we analyzed soil fertility dynamics when 2 and 3-year fallows were alternated with 3-year rotation of groundnut, cotton and sorghum. The control treatment consisted to continuous cultivate the soil in a rotation of groundnut/cotton/sorghum without fallow periods. For each rotation, two fertilisation rates were applied: no fertilisation and mineral fertiliser application during the cropping and/or the fallow periods. Yields of unfertilised crops, which averaged 1 t ha-1 during the first years of cultivation, were often nil in the long-term. In the long-term, yields of fertilised cotton and sorghum decreased by 32 and 50 %, respectively compared to the average of 2.4 and 1.6 t ha-1 obtained during the first decade of cultivation. The long-term decline in crop productivity was mitigated when fallow periods were alternated with cropping periods, and consequently there was partial compensation in terms of production for the unproductive fallowed plots. Long-term yields of fertilised cotton and sorghum in the periodically fallowed plots were 40 and 50 % higher than those in continuously cropped plots, respectively; they were 90 and 60 % higher than those in continuously cropped plots without fertilisation. Like for crop productivity, soil C, N and exchangeable Ca and Mg decreased less in periodically fallowed plots than in continuously cropped plots. The limited soil C decline when fallows were alternated with crops appears to be the consequence of no-tillage period rather than the effect of the highest C inputs to the soil.
Nutrient Cycling in ... arrow_drop_down Nutrient Cycling in AgroecosystemsArticle . 2015Data sources: DANS (Data Archiving and Networked Services)Nutrient Cycling in AgroecosystemsArticle . 2015 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert Nutrient Cycling in ... arrow_drop_down Nutrient Cycling in AgroecosystemsArticle . 2015Data sources: DANS (Data Archiving and Networked Services)Nutrient Cycling in AgroecosystemsArticle . 2015 . Peer-reviewedLicense: Springer TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s10705-015-9681-x&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2002 Italy, United KingdomPublisher:Kluwer Academic, Boston , Paesi Bassi Korhola, A.; Sorvari, S.; Rautio, M.; Appleby, P.G.; Dearing, J.A.; Hu, Y.; Rose, N.; Lami, A.; Cameron, N.G.;Responses to recent climatic changes in the sediment of subarctic Lake Saanajärvi in northwestern Finnish Lapland are studied by comparison of various biological and sedimentological proxies with the 200-year long climate record, specifically reconstructed for the site using a data-set of European-wide meteorological data. The multi-proxy evidence of simultaneously changing diatom, Cladocera, and chrysophyte assemblages along with the increased rates of organic matter accumulation and pigment concentrations suggest that the lake has undergone a distinct typological change starting from the turn of the 20th century. This change, indicating an increase in lake productivity, parallels a pronounced rise in the meteorologically reconstructed mean annual and summer temperatures in the region between ca. 1850 and 1930's. We postulate that, during the Little Ice Age, the lake was not, or was only weakly, thermally stratified during summer, whereas the subsequent increase in air and hence epilimnetic water temperatures resulted in the development of the present summer stratification. The increased thermal stability of the lake created more suitable conditions for the growth of phyto- and zooplankton and changed the overall primary production from benthos to plankton. Mineral magnetic and carbonaceous particle records suggest long-distance pollution, particularly since the 1920's, yet the observed changes in lake biota and productivity can hardly be explained by this very minor background pollution; the 20th century species configurations are typical of neutral waters and do not indicate any response to pollution.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1023/a:1020371902214&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1023/a:1020371902214&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2021 ItalyPublisher:Hindawi Limited Authors: Yagmur Atak; C. Ozgur Colpan; Adolfo Iulianelli;doi: 10.1002/er.7186
The most widely used process for hydrogen production is steam methane reforming. It can be carried out using a membrane reactor in which simultaneous hydrogen production and purification occur. Mathematical modeling of these reactors plays a key role in the selection of the design and operating parameters that yield high performance for the reactor. This review study discusses, synthesizes, and compares different mathematical modeling studies on the packed bed membrane reactors for hydrogen production from methane found in the literature. Different approaches used in these modeling studies for the hydrogen permeation steps, reaction kinetic expressions, phases involved (pseudo-homogeneous and heterogeneous), and spatial dimensions (one, two, and three dimensional) are given.
CNR ExploRA arrow_drop_down International Journal of Energy ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/er.7186&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!
more_vert CNR ExploRA arrow_drop_down International Journal of Energy ResearchArticle . 2021 . Peer-reviewedLicense: Wiley Online Library User AgreementData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/er.7186&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Article 2011 ItalyPublisher:IEEE Authors: Aliberti; Massimo;Intention of this work is to investigate the opportunity and feasibility of energy efficient networking in Home and Building automation protocols. Wired HBAS have traditionally devoted a relatively little attention to this point, especially if compared to wireless networks. This paper will try to address the issue by evaluating the introduction of power state switching in a real scenario and proposing the concept of functional and spatial adjacency among packets.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icce.2011.5722802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu1 citations 1 popularity Average influence Average impulse Average Powered by BIP!
visibility 1visibility views 1 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/icce.2011.5722802&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2019 PortugalPublisher:Elsevier BV Funded by:FCT | Laboratory for Robotics a..., FCT | SusCity, FCT | Associate Laboratory of ...FCT| Laboratory for Robotics and Engineering Systems ,FCT| SusCity ,FCT| Associate Laboratory of Energy, Transports and AeronauticsRoberto A. Varella; Gonçalo Duarte; Gonçalo Duarte; Marta V. Faria; Patrícia Baptista; Tiago L. Farias;Abstract This work assesses the impacts of aggressive driving behavior on pollutants emissions and energy consumption at a city level. Furthermore, it performs an economic analysis considering the potential avoided emissions and fuel savings and discusses potential policy measures to address this topic. The results showed that aggressive driving significantly impacts energy consumption and emissions, with energy consumption increasing by more than ∼200% and emissions by 330% for aggressive driving compared to non-aggressive driving (in MJ/km and in g/km, respectively). This increment was found to be even higher for diesel vehicles than for gasoline vehicles. On the contrary, gasoline vehicles showed higher percentages of increase for most emissions (CO, NOx and NO). Results also revealed that aggressive driving impacts are higher for local streets when examining the city level. Moreover, the economic analysis showed that significant cost reductions may be achieved by avoiding aggressive driving, reaching up to 52.5 k€ on a daily basis. In conclusion, this study is of particular relevance to policy makers and urban planners, enabling to obtain a comprehensive overview of the impacts of aggressive driving behaviors at a city level and providing new insights to perform further developments and to assess the feasibility of the implementation of policy measures.
Repositório Científi... arrow_drop_down Repositório Científico do Instituto Politécnico de LisboaArticle . 2019Energy Research & Social ScienceArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.erss.2018.09.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 25 citations 25 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
visibility 88visibility views 88 download downloads 52 Powered bymore_vert Repositório Científi... arrow_drop_down Repositório Científico do Instituto Politécnico de LisboaArticle . 2019Energy Research & Social ScienceArticle . 2019 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.erss.2018.09.006&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2013Publisher:Ovid Technologies (Wolters Kluwer Health) Authors: Mark P. Jensen; Johannes Vlaeyen; Warren R. Nielson; Petra A. Karsdorp;pmid: 23247005
Activity pacing (AP) is a concept that is central to many chronic pain theories and treatments, yet there remains confusion regarding its definition and effects.To review the current knowledge concerning AP and integrate this knowledge in a manner that allows for a clear definition and useful directions for future research.A narrative review of the major theoretical approaches to AP and of the empirical evidence regarding the effects of AP interventions, followed by an integrative discussion.The concept of AP is derived from 2 main traditions: operant and energy conservation. Although there are common elements across these traditions, significant conceptual and practical differences exist, which has led to confusion. Little empirical evidence exists concerning the efficacy of AP as a treatment for chronic pain.Future research on AP should be based on a clear theoretical foundation, consider the context in which the AP behavior occurs and the type of pacing problem ("underactivity" vs. "overactivity"), and should examine the impact of AP treatment on multiple clinical outcomes. We provide a provisional definition of AP and specific recommendations that we believe will move the field forward.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/ajp.0b013e3182608561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 115 citations 115 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!
more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1097/ajp.0b013e3182608561&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Journal 2014Publisher:Elsevier BV A. Charlotte P. Sewing; Viola Caretti; Tonny Lagerweij; Pepijn Schellen; Marc H.A. Jansen; Dannis G. van Vuurden; Sander Idema; Carla F.M. Molthoff; W. Peter Vandertop; Gertjan J.L. Kaspers; David P. Noske; Esther Hulleman;pmid: 25263805
Systemic delivery of therapeutic agents remains ineffective against diffuse intrinsic pontine glioma (DIPG), possibly due to an intact blood-brain-barrier (BBB) and to dose-limiting toxicity of systemic chemotherapeutic agents. Convection-enhanced delivery (CED) into the brainstem may provide an effective local delivery alternative for DIPG patients.The aim of this study is to develop a method to perform CED into the murine brainstem and to test this method using the chemotherapeutic agent carmustine (BiCNU). To this end, a newly designed murine CED catheter was tested in vitro and in vivo. After determination of safety and distribution, mice bearing VUMC-DIPG-3 and E98FM-DIPG brainstem tumors were treated with carmustine dissolved in DW 5% or carmustine dissolved in 10% ethanol.Our results show that CED into the murine brainstem is feasible and well tolerated by mice with and without brainstem tumors. CED of carmustine dissolved in 5% DW increased median survival of mice with VUMC-DIPG-3 and E98FM-DIPG tumors with 35% and 25% respectively. Dissolving carmustine in 10% ethanol further improved survival to 45% in mice with E98FM-DIPG tumors.Since genetically engineered and primary DIPG models are currently only available in mice, murine CED studies have clear advantages over CED studies in other animals.CED in the murine brainstem can be performed safely, is well tolerated and can be used to study efficacy of chemotherapeutic agents orthotopically. These results set the foundation for more CED studies in murine DIPG models.
Journal of Neuroscie... arrow_drop_down Journal of Neuroscience MethodsArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Journal of Neuroscience MethodsArticle . 2014 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jneumeth.2014.09.020&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 23 citations 23 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!
more_vert Journal of Neuroscie... arrow_drop_down Journal of Neuroscience MethodsArticle . 2014Data sources: DANS (Data Archiving and Networked Services)Journal of Neuroscience MethodsArticle . 2014 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jneumeth.2014.09.020&type=result"></script>'); --> </script>
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