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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Chen, Sophia; Zolo, Yvan; Ngulube, Lumbani; orcid Isiagi, Moses;
    Isiagi, Moses
    ORCID
    Harvested from ORCID Public Data File

    Isiagi, Moses in OpenAIRE
    +1 Authors

    Climate change is an emerging global health crisis, disproportionately affecting low- and middle-income countries (LMICs) where health outcomes are increasingly compromised by environmental stressors such as pollution, natural disasters, and human migration. With a focus on promoting health equity, Global Surgery advocates for expanding access to surgical care and enhancing health outcomes, particularly in resource-limited and disaster-affected areas like LMICs. The healthcare industry—and more specifically, surgical care—significantly contributes to the global carbon footprint, primarily through resource-intensive settings, i.e. operating rooms that generate greenhouse gases and substantial medical waste. Therefore, Global Surgery efforts aimed at improving surgical access through an increase in surgical volumes may inadvertently exacerbate health challenges for vulnerable populations by further contributing to environmental degradation. This predicament is particularly pronounced in LMICs, who already suffer from a disproportionate share of the global burden of disease, and where the demand for surgery is rising without corresponding resilient infrastructure. LMICs face a double jeopardy of health inequity coupled with climate vulnerability. As a movement positioned to improve health around the world, Global Surgery has an increasingly significant role in envisioning and ensuring a sustainable future. Global Surgery initiatives must prioritise sustainable infrastructure in both high-income countries (HICs) and LMICs, all while accounting for the unequal polluting contributions between HICs and LMICs and, consequently, moral responsibilities moving forward. Moreover, through targeting upstream causes of poor health at urban and perioperative levels, Global Surgery’s interventions may help to reduce the global burden of disease—avoiding preventable surgeries and their carbon footprints from the outset. Altogether, Global Surgery and climate change are two matters of social justice whose solutions must synergistically centralise the health of both the planet and its most vulnerable people.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ DSpace@MIT (Massachu...arrow_drop_down
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    BMC Surgery
    Article . 2025 . Peer-reviewed
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    PubMed Central
    Other literature type . 2025
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    BMC Surgery
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ DSpace@MIT (Massachu...arrow_drop_down
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      BMC Surgery
      Article . 2025 . Peer-reviewed
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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
      PubMed Central
      Other literature type . 2025
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      BMC Surgery
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Nousha H. Sabet; orcid Todd A. Wyatt;
    Todd A. Wyatt
    ORCID
    Harvested from ORCID Public Data File

    Todd A. Wyatt in OpenAIRE

    Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries. This manuscript presents selected key variables that represent the Alcohol Exposome. The primary variables that make up the Alcohol Exposome can include comorbidities such as cigarettes, poor diet, occupational hazards, environmental hazards, infectious agents, and aging. In addition to representing multiple factors, the Alcohol Exposome examines the various types of intercellular communications that are carried from one organ system to another and may greatly impact the types of injuries and metabolites caused by alcohol exposure. The intent of defining the Alcohol Exposome is to bring the newly expanded definition of Exposomics, meaning the study of the exposome, to the field of alcohol research and to emphasize the need for examining research results in a non-isolated environment representing a more relevant manner in which all human physiology exists.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Alcoholarrow_drop_down
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    Alcohol
    Article . 2025 . Peer-reviewed
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      Alcohol
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Haiwei Lu; Sara Jawdy; Jin-Gui Chen; Xiaohan Yang; +1 Authors

    For decades, Agrobacterium tumefaciens-mediated plant transformation has played an integral role in advancing fundamental and applied plant biology. The recent omnipresent emergence of synthetic biology, which relies on plant transformation to manipulate plant DNA and gene expression for novel product biosynthesis, has further propelled basic as well as applied interests in plant transformation technologies. The strong demand for a faster design-build-test-learn cycle, the essence of synthetic biology, is, however, still ill-matched with the long-standing issues of high tissue culture recalcitrance and low transformation efficiency of a wide range of plant species especially food, fiber and energy crops. To maximize the utility of plant material and improve the transformation productivity per unit plant form, we studied the regeneration and transformation efficiency of different types of explants, including leaf, stem, petiole, and root from Populus, a woody perennial bioenergy crop. Our results show that root explants, in addition to the above-ground tissues, have considerable regeneration capacity and amenability to A. tumefaciens and, the resulting transformants have largely comparable morphology, reporter gene expression, and transcriptome profile, independent of the explant source tissue. Transcriptome analyses mapped to regeneration stages and transformation efficiencies further revealed the expression of the auxin and cytokinin signaling and various developmental pathway genes in leaf and root explants undergoing early organogenesis. We further report high-potential candidate genes that may potentially be associated with higher regeneration and transformation efficiency. Overall, our study shows that explants from above- and belowground organs of a Populus plant are suitable for genetic transformation and tissue culture regeneration, and together with the underlying transcriptome data open new routes to maximize plant explant utilization, stable transformation productivity, and plant transformation efficiency.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Scientific Reportsarrow_drop_down
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    Scientific Reports
    Article . 2025 . Peer-reviewed
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    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
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    PubMed Central
    Other literature type . 2025
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    Scientific Reports
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      Scientific Reports
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      PubMed Central
      Other literature type . 2025
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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: orcid Marks, R.;
    Marks, R.
    ORCID
    Harvested from ORCID Public Data File

    Marks, R. in OpenAIRE
    orcid Ekwealor, J.;
    Ekwealor, J.
    ORCID
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    Ekwealor, J. in OpenAIRE
    orcid Artur, M.;
    Artur, M.
    ORCID
    Harvested from ORCID Public Data File

    Artur, M. in OpenAIRE
    orcid Bondi, L.;
    Bondi, L.
    ORCID
    Harvested from ORCID Public Data File

    Bondi, L. in OpenAIRE
    +35 Authors

    Abstract To thrive in extreme conditions, organisms have evolved a diverse arsenal of adaptations that confer resilience. These species, their traits, and the mechanisms underlying them comprise a valuable resource that can be mined for numerous conceptual insights and applied objectives. One of the most dramatic adaptations to water limitation is desiccation tolerance. Understanding the mechanisms underlying desiccation tolerance has important potential implications for medicine, biotechnology, agriculture, and conservation. However, progress has been hindered by a lack of standardization across sub-disciplines, complicating the integration of data and slowing the translation of basic discoveries into practical applications. Here, we synthesize current knowledge on desiccation tolerance across evolutionary, ecological, physiological, and cellular scales to provide a roadmap for advancing desiccation tolerance research. We also address critical gaps and technical roadblocks, highlighting the need for standardized experimental practices, improved taxonomic sampling, and the development of new tools for studying biology in a dry state. We hope that this perspective can serve as a roadmap to accelerating research breakthroughs and unlocking the potential of desiccation tolerance to address global challenges related to climate change, food security, and health.

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    Nature Communications
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    Research@WUR
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    Wageningen Staff Publications
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    Authors: orcid Doney, Scott C.;
    Doney, Scott C.
    ORCID
    Harvested from ORCID Public Data File

    Doney, Scott C. in OpenAIRE
    Wolfe, Wiley H.; McKee, Darren C.; Fuhrman, Jay G.;

    Scenarios to stabilize global climate and meet international climate agreements require rapid reductions in human carbon dioxide (CO2) emissions, often augmented by substantial carbon dioxide removal (CDR) from the atmosphere. While some ocean-based removal techniques show potential promise as part of a broader CDR and decarbonization portfolio, no marine approach is ready yet for deployment at scale because of gaps in both scientific and engineering knowledge. Marine CDR spans a wide range of biotic and abiotic methods, with both common and technique-specific limitations. Further targeted research is needed on CDR efficacy, permanence, and additionality as well as on robust validation methods—measurement, monitoring, reporting, and verification—that are essential to demonstrate the safe removal and long-term storage of CO2. Engineering studies are needed on constraints including scalability, costs, resource inputs, energy demands, and technical readiness. Research on possible co-benefits, ocean acidification effects, environmental and social impacts, and governance is also required.

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    Annual Review of Marine Science
    Article . 2025 . Peer-reviewed
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    OceanRep
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      Annual Review of Marine Science
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      OceanRep
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    Authors: orcid Luo Xu;
    Luo Xu
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    orcid Ning Lin;
    Ning Lin
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    Dazhi Xi; Kairui Feng; +1 Authors

    Blackouts in recent decades show an increasing prevalence of power outages due to extreme weather events such as hurricanes. Precisely assessing the spatiotemporal outages in distribution networks, the most vulnerable part of power systems, is critical to enhance power system resilience. The Sequential Monte Carlo (SMC) simulation method is widely used for spatiotemporal risk analysis of power systems during extreme weather hazards. However, it is found here that the SMC method can lead to large errors by directly applying the fragility function or failure probability of system components in time-sequential analysis, particularly overestimating damages under evolving hazards with high-frequency sampling. To address this issue, a novel hazard resistance-based spatiotemporal risk analysis (HRSRA) method is proposed. This method converts the time-varying failure probability of a component into a hazard resistance as a time-invariant value during the simulation of evolving hazards. The proposed HRSRA provides an adaptive framework for incorporating high-spatiotemporal-resolution meteorology models into power outage simulations. By leveraging the geographic information system data of the power system and a physics-based hurricane wind field model, the superiority of the proposed method is validated using real-world time-series power outage data from Puerto Rico during Hurricane Fiona 2022. Comment: 10 pages, 10 figures

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    IEEE Transactions on Power Systems
    Article . 2025 . Peer-reviewed
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      IEEE Transactions on Power Systems
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    Authors: orcid bw Nikolopoulos, Anna;
    Nikolopoulos, Anna
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    Azetsu-Scott, Kumiko; Cooper, Lee W.; Frey, Karen E.; +10 Authors

    The Arctic climate system is in great distress, warming faster than the rest of the world and transforming more rapidly than previously anticipated. Sustained and harmonized multidisciplinary observations at key locations are needed to fill knowledge gaps and evaluate the ongoing climate change impacts on the complex Arctic marine system. For more than a decade, the Distributed Biological Observatory (DBO) has functioned as a “detection array” for ecosystem changes and trends in the Pacific sector of the Arctic Ocean. This long-term collaborative initiative builds on active involvement of scientists conducting in situ observations within marine disciplines to systematically document how the arctic marine ecosystem is transforming with environmental change. The DBO concept is currently being expanded into other sectors of the Arctic, including Davis Strait and Baffin Bay, the Atlantic Arctic gateway area, and the East Siberian Sea. Through increased collaboration and joint practices, findings from these regional areas can leverage to pan-Arctic perspectives and improve our understanding of the entire Arctic Ocean. Common practices are now being developed, including key phenomena and relevant indicators to study. Also, we strive towards harmonized routines for sampling, analysis and data sharing to increase the comparability across both disciplines and regions, and to improve the usability of our in-situ observations also for the modelling and remote sensing scopes. An ambition is, moreover, to expand from today's predominantly open-sea coverage towards coastal regions, to the benefit of both local communities and researchers. The process of establishing a pan-Arctic DBO network is to a large part facilitated by the EU Horizon project Arctic PASSION (2022-2025). Here, we present the latest developments and shared priorities, as well as our vision of how to incorporate our efforts into other parallel processes aiming to strengthen the pan-Arctic observing system towards, during and beyond the upcoming IPY.

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    Authors: orcid Yongsoon Park;
    Yongsoon Park
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    orcid bw Seungbo Choi;
    Seungbo Choi
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    orcid Geon Heo;
    Geon Heo
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    orcid Gab-Su Seo;
    Gab-Su Seo
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    Gab-Su Seo in OpenAIRE
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    IEEE Transactions on Smart Grid
    Article . 2025 . Peer-reviewed
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      IEEE Transactions on Smart Grid
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    Authors: orcid Layse C. de Souza;
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    orcid Christopher D. Herring;
    Christopher D. Herring
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    orcid bw Lee R. Lynd;
    Lee R. Lynd
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    Lee R. Lynd in OpenAIRE

    ABSTRACT Thermoanaerobacterium thermosaccharolyticum is an anaerobic and thermophilic bacterium that has been genetically engineered for ethanol production at very high yields. However, the underlying reactions responsible for electron flow, redox equilibrium, and how they relate to ethanol production in this microbe are not fully elucidated. Therefore, we performed a series of genetic manipulations to investigate the contribution of hydrogenase genes to high ethanol yield, generating evidence for the importance of hydrogen-reacting enzymes in ethanol production. Our results indicate that a high ethanol yield, >85% of the theoretical maximum, only occurs when the hfsD, hydAB , and nfnAB genes are all present together, while the hfsB gene is absent. We propose that the products of these three gene clusters facilitate an NADPH-generating reaction via hydrogen cycling, with a stoichiometry comparable with a canonical ferredoxin:NADP + oxidoreductase (FNOR; EC 1.18.1.2) reaction. The hypothesized mechanism provides a balance of nicotinamide cofactors and facilitates ferredoxin recycling, leading to progress in optimizing the energy conversion of biomass-derived sugars to ethanol. IMPORTANCE Our study elucidates the crucial role of electron flow and redox balancing mechanisms in improving ethanol yields from renewable biomass. We delve into the mechanism of electron transfer, highlighting the potential of key genes to be leveraged for enhanced ethanol production in anaerobic microbial species. We suggest by genetic investigation the existence of a novel Ferredoxin:NADP+ Oxidoreductase (FNOR) reaction, comprising HfsD, HydAB, and NfnAB enzymes, as a promising avenue for achieving balanced stoichiometry and efficient ethanol synthesis. Our findings not only advance the understanding of microbial metabolism but also offer practical insights for developing strategies to improve bioenergy production and sustainability.

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    Applied and Environmental Microbiology
    Article . 2025 . Peer-reviewed
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      Applied and Environmental Microbiology
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    Authors: Wentao Hou; Andres Eduardo Araujo-Correa; Shen Qiu; orcid bw Crystal Otero Velez;
    Crystal Otero Velez
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    Aqueous zinc batteries are emerging technologies for energy storage, owing to their high safety, high energy, and low cost. Among them, the development of low-cost and long-cycling cathode materials is of crucial importance. Currently, Zn-ion cathodes are heavily centered on metal-based inorganic materials and carbon-based organic materials; however, the metal–organic compounds remain largely overlooked. Herein, we report the electrochemical performance of metal phthalocyanines, a large group of underexplored compounds, as alternative cathode materials for aqueous zinc batteries. We discover that the selection of transition metal plays a vital role in affecting the electrochemical properties. Among them, iron phthalocyanine exhibits the most promising performance, with a reasonable capacity (~60 mAh g−1), a feasible voltage (~1.1 V), and the longest cycling (550 cycles). The optimal performance partly results from the utilization of zinc chloride “water-in-salt” electrolyte, which effectively mitigates material dissolution and enhances battery performance. Consequently, iron phthalocyanine holds promise as an inexpensive and cycle-stable cathode for aqueous zinc batteries.

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    Batteries
    Article . 2025 . Peer-reviewed
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    Batteries
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