• Energy Research
• 3. Good health close
• 11. Sustainability close
• 12. Responsible consumption close
• 1. No poverty close
• French close

Ce jeu de données a été produit dans le cadre de l "Atelier master" du programme de recherche Archival City. La liste détaillée des éléments du jeu de données est contenue dans le document ACP04_FA01_AP. Ce jeu de données est décrit dans le research paper suivant https://archivalcity.hypotheses.org/5455. This dataset was produced as part of the "Master Workshop" of the Archival City research programme. The detailed list of elements in the dataset is contained in document ACP04_FA01_AP. This dataset is described in the following research paper https://archivalcity.hypotheses.org/5455. https://archivalcity.hypotheses.org/5455

The present study was carried out to evaluate the antioxidant and anti-inflammatory capacity, and acute toxicity of Moroccan Erica arborea leaves.Antioxidant capacity was assessed by diphenyle-picryl-hydrazyl (DPPH), phosphomolybdate (PPM) and ferric reducing antioxidant power (FRAP) tests and anti-inflammatory capacity was evaluated by hind paw oedema model using carrageenan-induced inflammation in rat. The acute toxicity was evaluated using mice.Acute toxicity of ethanolic extract of E. arborea showed no sign of toxicity at dose of 5 g/kg B.W. Our extracts have important antioxidant properties. The efficient concentration of the ethanolic extract (10.22 μg/ml) required for decreasing initial DPPH concentration by 50% was comparable to that of standard solution butyl-hydroxy-toluene (BHT) (8.87 μg/ml). The administration of ethanolic extract at doses of 200 and 400mg/kg B.W. was able to prevent plantar oedema and exhibited a significant inhibition against carrageenan-induced inflammation when compared to the control group (NaCl 0.9%) but comparable to those of diclofenac (reference drug).Our results show that the leaves of E. arborea may contain some bioactive compounds which are responsible for the antioxidant and anti-inflammatory activities observed here. Our finding may indicate the possibility of using the extracts of this plant to prevent the antioxidant and inflammatory processes.

This study provides a tool by means of which a road planner, usually a civil engineer, can achieve a durable infrastructure of high quality, acceptable to all parties concerned. The various elements which facilitate the work of planning are united into a modernized methodology for the elaboration of road projects, called a methodology of concert. After analysing the sort of problems encountered in the planning of road infrastructure (Chapter 1), the author classifies the main causes of these into a hierarchy. This brings to light many factors which may stem from the structure of the project, the environment or from the various participants. The modernization of the working methods of road planners is a highly practical idea based on case studies (Chapter 2). The particular study on which this work is based is the "Comparaison de variantes 1999", made on the A 144 road between the cities of Villeneuve and Le Bouveret. From an initial group of four variants, which were a source of much contention between the interested parties, an optimal and consensual solution, called "Solution COPIL", was evolved in seven months, by means of this study. The choice of this solution was based on a method of multicriteria decision analysis of a completely aggregational form. This used the weightings defined by all the political partners in the study. The present author was allowed to sit in on about fifteen working sessions of the Technical Group and of the Guiding Committee, which consists of the political partners. The examination of this particular case provided him with much valuable information about the process of elaboration of a road plan. The requirements and aims of road infrastructure are analysed (Chapter 3). Here, the focus is on the definition of individual and collective needs and the evolution of social expectation of the general public. The implementation of public policy is then examined. Particular emphasis is laid on the principal public policies whose spatial incidence affects the road plan : land distribution, transport and environment. Some attention is paid to the consideration of mobility, its value, characteristics and future developments. The difference between the standard and the norm of road infrastructure is described explicitly. The various stages of the process of elaboration of a road plan are analysed in depth. (Chapter 4) Particular attention is paid to the initial stages of impulsion for the elaboration of the project and of the identification of needs, since these influence strongly the quality and the acceptability of the project. The author then proposes that the various stages of road infrastructure be presented in the form of a life cycle of which the present study only concerns some aspects. Various special procedures are then analysed critically in order to extract propositions to be integrated into the methodology of concert. The type of partners in the road project and the characteristics of the relationships between them are discussed. (Chapter 5) The set of weightings made by the political partners in the case study "Comparaison de variantes 1999" are used to analyze the relations between the various participants in this study. A "representative profile of a participant" is defined from the examination of their individual weighting profiles. The notion of sustainability is presented (Chapter 6). After a recapitulation of definitions and of the reasons for this new idea, the principles of a durable mobility are presented. The practical aspects of this new paradigm of society for the planner are defined and discussed. They concern the inclusion of the life cycle in the analysis of the effects of a project, the weighing of interests from the three points of view of economy, social utility and the environment, public participation and the use of consultation right from the start of the study. Public participation (Chapter 7) is an important element in the elaboration of a road plan as it ensures its acceptation by the public. It may even allow the phenomenon of appropriation of a project by peripheral partners to develop. The various forms of public participation are presented in a table showing almost seventy which can affect a road project. The detailed description of some of these methods are given in appendix. Rules for applying the methodology of concert are then presented and the advantages and limits of this are discussed. After in-depth consideration of the decision procedure and its participants, with details of the various subjective and objective factors which may influence it, the study describes the methods of multicriteria decision analysis. (Chapter 8) Terminology is defined and the main types of these methods are presented. In this study, partial aggregation methods have been applied to the road infrastructure projects. These methods may be divided into three categories according to whether they are applicable to a situation of choice, of sorting or of order. A complete presentation is then given of the principles and ways of using the various methods of partial aggregation of the Electre family (I, II, III, IV, IS and Tri). For projects of road infrastructure, the method of partial aggregation Electre III is suggested. This method is based on the idea of fuzzy criteria, defined by thresholds of preference, indifference or of veto. It can be used with computer software which greatly simplifies the work of the planner. To illustrate the use of this method, Electre III have been applied to the case of "Comparaison de variantes 1999". The method was used on the set of weightings defined by the members of the Guiding Committee. The specific software is convivial and intuitively simple to use, so that the author was able to recommend it to the road planner. Information systems of spatial reference are described and their relevance for road projects in the establishment of optimal corridors or as a support for a method of multicriteria decision analysis. The methodology of concert for the elaboration of road plans is presented in detail (Chapter 9) in the form of successive flow diagrams illustrating the various stages of the procedure. These diagrams, based on an iterative process of study, provide the basis of the methodology of concert. They are intended for the road planner who follows them through and orients his planning according to his answers to the various questions contained there. In conclusion (Chapter 10), various prospects for the utilization of the proposed modernized methodology are indicated, together with the lines of possible future research suggested by the results and ideas contained in this study.

The risk of developing a tumor of the nervous system in humans is analysed in several studies of populations, exposed to ionising radiation for medical reasons, or exposed to military or occupational radiation. The main data come from series of patients who underwent radiotherapy during childhood: a high incidence of tumors of the nervous system is found after irradiation of one to a few grays as treatment of a benign disease (especially tinea capitis), as well as after irradiation at higher doses of a few tens of grays for the treatment of cancer (in particular cerebral irradiation in acute lymphoblastic leukaemia). The type of radiation-induced tumors is variable, but meningioma is more frequent after low doses and glioma and sarcoma after higher doses used in the treatment of neoplastic diseases. A dose-effect relationship appeared between the risk of tumor of the nervous system and the radiation dose. The risk was higher when radiation was delivered at a younger age. Much less data are available after radiotherapy in the adulthood, but an increased risk of cerebral tumor appears in the series of ankylosing spondylitis patients. As for the exposures to radiodiagnosis exams, the main problem is the risk of cerebral tumor in children whose mother has undergone abdominal or pelvic X-rays during pregnancy. No risk of neurologic tumor was found in the A-bomb survivors irradiated at Hiroshima and Nagasaki. Occupational exposure to ionising radiation has been incriminated in the first radiologists exposed to high doses. In nuclear industry workers, the results of epidemiological studies are contradictory and at the present time it is not possible to link their radiologic exposure with a risk of tumor of the nervous system. In populations living near nuclear plants, mortality due to tumors of the nervous system was not increased.

We have studied the hyperglycemic effect of glucagon (20 microgram/kg) and adrenaline (5 microgram/kg/mn/3 mn) on the rat subjected to a subacute alcoholic intoxication (6,4 g/kg by day during 12 days). The hyperglycemic action of the glucagon is increased while that of the adrenaline slightly decreased. So, the alcoholic intoxication allows to dissociate the both mechanisms of the glycogenolytic action of both hormones. Two hypothesis are brought forward in the discussion.

With over 70,000 patients treated worldwide, protontherapy has an evolution on their clinical applications and technological developments. The ballistic advantage of the Bragg peak gives the possibility of getting a high conformation of the dose distribution to the target volume. Protontherapy has accumulated a considerable experience in the management of selected rare malignancies such as uveal melanomas and base of the skull chordomas and chondrosarcomas. The growing interest for exploring new and more common conditions, such as prostate, lung, liver, ENT, breast carcinomas, as well as the implementation of large pediatric programs advocated by many experts has been challenged up to now by the limited access to operational proton facilities, and by the relatively slow pace of technical developments in terms of ion production, beam shaping and modelling, on-line verification etc. One challenge today is to deliver dynamic techniques with intensity modulation in clinical facilities as a standard treatment. We concentrate in this paper on the evolution of clinical indications as well as the potentialities of new technological concepts on ion production, such as dielectric walls and laser-plasma interactions. While these concepts could sooner or later translate into prototypes of highly compact equipments that would make easier the implantation of cost-effective hospital-based facilities, the feasibility of their clinical use must still be proved.

Acute alcohol ingestion can induce drug interactions, either pharmacokinetic or pharmacodynamic. Metabolically, they especially result from interference in the enzymatic systems which catalyse ethanol oxidation, the blocking of alcohol dehydrogenase, blocking of the microsomal oxidation system of ethanol with accumulation of the xenobiotic and risk of overdose, and blocking of acetaldehyde dehydrogenase with an antabuse effect. Pharmacodynamically, the main interactions result from the action of drugs having a sedative effect, such as tranquilizers but also antidepressants, neuroleptics, analgesics, H1 antihistamines, central antihypertensive drugs (CNS depressant?), etc. This sedative effect is increased by ethanol, which can be dangerous in at-risk situations.

Serum concentrations of psychotropic drugs were measured in 363 drivers injured in road accidents and admitted to the emergency department of Angers regional university hospital. The figures obtained were correlated to the presumed responsibility of each driver in the accident. Benzodiazepines and phenobarbitone were found in the serum of 39 drivers, and responsibility was significantly increased in this group. The role played by these medicines in road accidents has often been alluded to in the literature, but the value of these previous studies was limited by the lack of quantitative assays. Measuring serum concentrations has permitted a more accurate analysis of the relationship between responsibility for road accident and consumption of psychotropic drugs, including barbiturates. This has prompted the authors to organize a regional information campaign intended for the general public and doctors and aimed at drawing attention to the higher risk of accident among road users taking these drugs.

Epidemiological studies have shown the role of alcohol in esophageal cancer in the West of France. Experiments were undertaken on Wistar rats to study the effect of locally consumed alcoholic beverages on the esophagus. Neither histological modifications, precancerous lesions nor cancer were observed in the animals. There was no significant excess of benign or malignant tumours in treated animals when compared with controls.

Early and appropriate treatment of acute pancreatitis (AP) depends on early causal diagnosis. Published studies have shown favourable results following sphincterotomy performed within the 72 hours of onset of severe gallstone-associated AP. Among the various bio-clinical indices, the lipase/amylase (L/A) ratio, computed within 72 hours after onset, has been shown to discriminate between alcoholic and non alcoholic AP. Our study evaluates the data of biochemical disorders in 51 patients presenting with an episode of AP; these patients were divided into 3 groups: A: alcoholic AP, n = 15; B: biliary AP, n = 25; and C: post-ERCP AP, n = 11. These 3 groups were similar with respect to clinical severity of AP and CT scan. The time delays between onset of the symptoms and the biochemical assay were 1.9 +/- 0.3, 1.9 +/- 0.2 and 0.6 +/- 0.3 d (P < 0.01). AST, ALT, bilirubin, GGT and alkaline phosphatase were significantly (P < 0.05) greater in group B. Blamey's score was 0.5 +/- 0.2, 2.8 +/- 0.2 and 2.5 +/- 0.4 in groups A, B and C respectively. Serum amylase, serum lipase and L/A ratio were identical in groups A and B. The decrease in serum amylase after 48 hours was more important only in group B (56 +/- 8, 80 +/- 4, 47 +/- 3% respectively in groups A, B and C). L/A ratio was significantly greater in group C when compared with group A and B (1.7 +/- 0.4, 1.5 +/- 0.2 and 2.2 +/- 0.3 in groups A, B and C respectively).(ABSTRACT TRUNCATED AT 250 WORDS)