Hyperlepidemy or the increase in the rate of blood lipids is a condition which is developing as an illness in new decades. With regard to problems as a result of using drugs and also benefits of physical activity to improve hyperlepidemia, this research has tried to study the effect of the physical activity with regard to energy expenditure on blood lipids. Materials and Methods: To do the study, 21 hyperlepidemic men were selected and received a training protocol (the physical activity with 450 and 600 kcal). Results: Results showed that burning 450 kcal per season caused a significant change at levels of total cholesterol and HDL (P≤0/05). However to cause significant changes at levels of the triglyceride need to burn 600 kcal energy expenditure per season (P≤0/05). No significant change was found for both groups in relation to LDL levels and so can be concluded that, burning 600 kcal per session is not enough to cause change at LDL levels. Conclusion: In general, results showed that to cause positive changes at levels of HDL, less physical activity is needed, but to cause positive changes at levels of triglyceride, physical activity and energy expenditure should be increased.