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A comparison of calcium antagonists and diazepam in reducing ethanol withdrawal tremors

doi: 10.1007/bf00445563
pmid: 2594904
The calcium antagonists nimodipine and dantrolene were compared with diazepam in an animal model of tolerance and physical dependence upon ethanol. Nimodipine and dantrolene were both effective in suppressing withdrawal tremors but diazepam was clearly superior to both agents. These results suggest that the ethanol withdrawal syndrome is only partially mediated by increased calcium flux.
- National Institutes of Health United States
- National Institute On Alcohol Abuse and Alcoholism United States
- National Institute On Alcohol Abuse and Alcoholism United States
- National Institute of Health Pakistan
Brain Chemistry, Male, Diazepam, Ethanol, Rats, Inbred Strains, Calcium Channel Blockers, Dantrolene, Rats, Substance Withdrawal Syndrome, Tremor, Animals, Nimodipine
Brain Chemistry, Male, Diazepam, Ethanol, Rats, Inbred Strains, Calcium Channel Blockers, Dantrolene, Rats, Substance Withdrawal Syndrome, Tremor, Animals, Nimodipine
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).52 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
