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Comparison of ethanol locomotor sensitization in adolescent and adult DBA/2J mice

descriptionPublicationkeyboard_double_arrow_right Article , Journal 22 Dec 2007Publisher:Springer Science and Business Media LLCJournal:Psychopharmacology, volume 197, pages 361-370 (issn: 0033-3158, eissn: 1432-2072,

Authors: Clyde W. Hodge; Rebekah A. Stevenson; Joyce Besheer;

doi: 10.1007/s00213-007-1038-y , 10.17615/fvh2-jp54

pmid: 18157521

pmc: PMC2531208

Comparison of ethanol locomotor sensitization in adolescent and adult DBA/2J mice

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Abstract

The mammalian adolescent period is characterized by enhanced vulnerability to drug-induced neuroadaptations. Epidemiological evidence indicates that individuals who start drinking alcohol during adolescence are four times more likely to develop alcohol dependence in adulthood, but little is known about the adaptive mechanism(s) that may underlie this observation. Behavioral sensitization in rodents is a model of neurobehavioral plasticity that occurs following repeated drug exposure and may underlie components of addiction.

Related Organizations

University of North Carolina at Chapel Hill
United States
UNC Lineberger Comprehensive Cancer Center
United States
Center for Alcohol Studies
Thailand
Center for Alcohol Studies
Thailand
UNC Lineberger Comprehensive Cancer Center
United States

Keywords

Male, Neuronal Plasticity, Dose-Response Relationship, Drug, Ethanol, Metabolic Clearance Rate, Age Factors, Brain, Motor Activity, Mice, Mice, Inbred DBA, Animals, Arousal, Injections, Intraperitoneal

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	55
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%