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The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats

Name: The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats
Keywords: Discrimination Learning, Male, Dose-Response Relationship, Drug, Ethanol, Animals, Rats, Long-Evans, Self Administration, Corticosterone, Stress, Psychological, Rats

descriptionPublicationkeyboard_double_arrow_right Article , Journal 21 Oct 2011Publisher:Springer Science and Business Media LLCJournal:Psychopharmacology, volume 220, pages 809-822 (issn: 0033-3158, eissn: 1432-2072,

Copyright policy )Funded by:NIH | Novel Mechanism of Ethano..., NIH | The impact of HPA axis dy..., NIH | Molecular Mechanisms of E...

Authors: Reginald Cannady; Joyce Besheer; Clyde W. Hodge; Kristen R. Fisher; Julie J. M. Grondin;

doi: 10.1007/s00213-011-2533-8 , 10.17615/ckgz-7915

pmid: 22016195

pmc: PMC3422726

The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats

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Abstract

Repeated and/or heightened elevations in glucocorticoids (e.g., repeated stress) can promote escalated drug-taking behaviors and induce compromised HPA axis function. Given that interoceptive/subjective drug cues are a fundamental factor in drug-taking behavior, we sought to determine the effects of exposure to repeated elevations in the glucocorticoid corticosterone (CORT) on the interoceptive effects of alcohol in rats using drug discrimination techniques.

Related Organizations

Center for Alcohol Studies
Thailand
Center for Alcohol Studies
Thailand
UNC Lineberger Comprehensive Cancer Center
United States
UNC Lineberger Comprehensive Cancer Center
United States
University of North Carolina at Chapel Hill
United States

Keywords

Discrimination Learning, Male, Dose-Response Relationship, Drug, Ethanol, Animals, Rats, Long-Evans, Self Administration, Corticosterone, Stress, Psychological, Rats

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