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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Applied Microbiology...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Applied Microbiology and Biotechnology
Article . 2012 . Peer-reviewed
License: Springer TDM
Data sources: Crossref
Applied Microbiology and Biotechnology
Article . 2013
Data sources: Europe PubMed Central
Applied Microbiology and Biotechnology
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α-Ketoglutaric acid production by Yarrowia lipolytica and its regulation

descriptionPublicationkeyboard_double_arrow_right Article , Journal 17 Jun 2012Publisher:Springer Science and Business Media LLCJournal:Applied Microbiology and Biotechnology, volume 96, pages 783-791 (issn: 0175-7598, eissn: 1432-0614, Copyright policy )
Authors: Julia N. Lunina; Svetlana V. Kamzolova; Igor G. Morgunov; Maria N. Chiglintseva;

doi: 10.1007/s00253-012-4222-x

pmid: 22707058

α-Ketoglutaric acid production by Yarrowia lipolytica and its regulation

Abstract

The yeast Yarrowia lipolytica VKM Y-2412 was selected as a prospective producer of α-ketoglutaric acid (KGA) from ethanol. The following peculiarities were found: (1) the intensive KGA production occurred only under the limitation of cell growth by thiamine and the excess of ethanol and nitrogen, (2) the production of KGA from ethanol required increased amount of zinc and iron ions, and (3) KGA production increased significantly with a high aeration at pH medium equal to 3.5. Under optimal conditions, the Y. lipolytica VKM Y-2412 produced up to 172 g l(-1) of KGA with the mass yield coefficient of 0.70 g g(-1).

Related Organizations
Keywords

Ethanol, Nitrogen, Iron, Yarrowia, Zinc, Gene Expression Regulation, Fungal, Ketoglutaric Acids, Thiamine, Metabolic Networks and Pathways

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 53
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
53
Top 10%
Top 10%
Top 10%
bronze