AbstractAssessing the regional responses to different Global Warming Levels (GWLs; e.g. + 1.5, 2, 3 and 4 ºC) is one of the most important challenges in climate change sciences since the Paris Agreement goal of keeping global temperature increase well below 2 °C with respect to the pre-industrial period. Regional responses to global warming were typically analyzed using global projections from Global Climate Models (GCMs) and, more recently, using higher resolution Regional Climate Models (RCMs) over limited regions. For instance, the IPCC AR6 WGI Atlas provides results of the regional response to different GWLs for several climate variables from both GCMs and RCMs. These results are calculated under the assumption that the regional signal to global warming is consistent between the GCMs and the nested RCMs. In the present study we investigate the above assumption by evaluating the consistency of regional responses to global warming from global (CMIP5) and regional (CORDEX) projections. The dataset aggregated over the new IPCC reference regions, available from the IPCC AR6 WGI Atlas repository, is analyzed here for temperature and precipitation. The existing relationships between the regional climate change signals and global warming are compared for both CMIP5 and CORDEX. Our results show significant linear scaling relationships between regional changes and global warming for most of the regions. CORDEX and CMIP5 show remarkably similar scaling relationships and similar robustness in the emergence of the climate change signal for most of the regions. These results support the use of regional climate models in the context of global warming level studies.