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Mechanisms of Immune Status Disorders in Chronic Ethanol Intoxication

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Nov 2011Publisher:Springer Science and Business Media LLCJournal:Bulletin of Experimental Biology and Medicine, volume 152, pages 90-92 (issn: 0007-4888, eissn: 1573-8221,

Authors: V. A. Grishin; V. G. Lim; P. F. Zabrodskii; A. V. Kuzmin;

doi: 10.1007/s10517-011-1462-1

pmid: 22803049

Mechanisms of Immune Status Disorders in Chronic Ethanol Intoxication

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Abstract

Experiments of outbred albino rats showed that chronic ethanol intoxication (20 days, summary dose 5 LD(50)) inhibited immune reactions mainly mediated by Th1-cells, increased blood corticosterone concentration, reduced T-lymphocyte acetylcholinesterase activity, blood concentrations of IFN-γ, IL-2, IL-4, IL-10, and increased IL-6 level.

Related Organizations

Saratov State Medical University
Russian Federation
Saratov State Medical University
Russian Federation

Keywords

Male, Ethanol, Central Nervous System Depressants, Th1 Cells, Immunity, Humoral, Rats, Th2 Cells, Acetylcholinesterase, Animals, Outbred Strains, Animals, Cytokines, Female, Corticosterone, Alcoholic Intoxication, Spleen

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