In mountain ecosystems, plants are sensitive to climate changes, and an entire range of species distribution can be observed in a small area. Therefore, mountains are of great interest for climate-growth relationship analysis. In this study, the Siberian spruce’s (Picea obovata Ledeb.) radial growth and its climatic response were investigated in the Western Sayan Mountains, near the Sayano-Shushenskoe Reservoir. Sampling was performed at three sites along an elevational gradient: at the lower border of the species range, in the middle, and at the treeline. Divergence of growth trends between individual trees was observed at each site, with microsite landscape-soil conditions as the most probable driver of this phenomenon. Cluster analysis of individual tree-ring width series based on inter-serial correlation was carried out, resulting in two sub-set chronologies being developed for each site. These chronologies appear to have substantial differences in their climatic responses, mainly during the cold season. This response was not constant due to regional climatic change and the local influence of the nearby Sayano-Shushenskoe Reservoir. The main response of spruce to growing season conditions has a typical elevational pattern expected in mountains: impact of temperature shifts with elevation from positive to negative, and impact of precipitation shifts in the opposite direction. Chronologies of trees, growing under more severe micro-conditions, are very sensitive to temperature during September-April and to precipitation during October-December, and they record both inter-annual and long-term climatic variation. Consequently, it would be interesting to test if they indicate the Siberian High anticyclone, which is the main driver of these climatic factors.