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Action of ethanol and salsolinol on opiate receptor function

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1982Publisher:Elsevier BVJournal:Brain Research, volume 232, pages 506-510 (issn: 0006-8993,

Authors: Laura Lucchi; PierFranco Spano; M. Trabucchi; A. Bosio;

doi: 10.1016/0006-8993(82)90297-9

pmid: 6322918

Action of ethanol and salsolinol on opiate receptor function

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Abstract

Ethanol may act at the enkephalinergic receptor level through condensation products such as salsolinol. This fact has been demonstrated by studying the 'in vitro' and 'in vivo' salsolinol interaction on enkephalinergic receptor sites labeled by [3H-Met] enkephalin. The modification induced by chronic ethanol and salsolinol on this neuronal system is a reduction of the affinity of the receptor for its ligand. These data suggest that a down regulation process due to the continuous opiate receptor stimulation occurs after ethanol administration.

Keywords

Male, Ethanol, Enkephalin, Methionine, Brain, Rats, Inbred Strains, Acetaldehyde, Isoquinolines, Corpus Striatum, Frontal Lobe, Rats, Kinetics, Receptors, Opioid, Animals

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	53
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%