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Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Nov 1985 Italy Publisher:Elsevier BVJournal:Brain Research, volume 348, pages 201-203 (issn: 0006-8993,

Authors: GESSA GL; MUNTONI F; COLLU, MARIA; VARGIU L; MEREU G.;

doi: 10.1016/0006-8993(85)90381-6

pmid: 2998561

handle: 11584/6484

Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

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Abstract

In unanesthetized rats the intravenous administration of low doses of ethanol (0.125-0.5 g/kg) produced a dose-dependent increase (30-80%) in the firing rate of dopaminergic (DA) neurons in the Ventral Tegmental Area (VTA). In agreement with previous observations, a dose range between 0.5 and 2 g/mg of ethanol was needed to produce comparable stimulant responses in DA neurons of the Substantia Nigra Pars Compacta. However, in anesthetized rats, doses of ethanol up to 1 g/kg failed to activate VTA-DA neurons. The high sensitivity of VTA-DA neurons to ethanol activation suggests that they might be involved in the reinforcing properties of the drug.

Country

Italy

Related Organizations

University of Cagliari
Italy

Keywords

Male, Ethanol, Tegmentum Mesencephali, Dopamine, Rats, Inbred Strains, Synaptic Transmission, Rats, Receptors, Dopamine, Animals

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