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Blockade of δ-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1993 Italy Publisher:Elsevier BVJournal:European Journal of Pharmacology, volume 230, pages 239-241 (issn: 0014-2999,

Authors: ACQUAS, ELIO MARIA GIOACHINO; MELONI M; DI CHIARA, GAETANO;

doi: 10.1016/0014-2999(93)90809-v

pmid: 8380771

handle: 11584/101232

Blockade of δ-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release

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Abstract

Naltrindole, a specific delta-opioid antagonist, infused by reverse dialysis in the nucleus accumbens of freely moving rats completely prevented the increase in extracellular dopamine concentrations elicited in the nucleus accumbens by ethanol (1.0 g/kg i.p.) as well as by the delta-opioid receptor agonist [D-Ala2]deltorphin II (50 microM), also perfused by reverse dialysis, but not by cocaine (15 mg/kg s.c.). The results provide in vivo evidence for a critical role of delta-opioid receptors in the dopamine-releasing properties of ethanol in vivo.

Country

Italy

Related Organizations

University of Cagliari
Italy

Keywords

Male, Indoles, Ethanol, Dopamine, Narcotic Antagonists, Naltrexone, Nucleus Accumbens, Rats, Rats, Sprague-Dawley, Cocaine, Morphinans, Receptors, Opioid, delta, Animals, Oligopeptides

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