Increased uptake of choline by neural cell cultures chronically exposed to ethanol
Copyright policy )Increased uptake of choline by neural cell cultures chronically exposed to ethanol
Abstract The effects of acute and chronic exposure to ethanol on the high affinity uptake of choline have been studied in glioblast and neuroblast cell lines. Acute treatment with 100 mM ethanol produced no changes in the rate of incorporation of (methyl- 14 C) choline. Chronic exposure to 100 mM ethanol led to an increase of choline uptake as a function of time reaching a maximum and then returning to control values. Differences were observed in the rate at which the various cells achieved this increase, with the cholinergic clone showing the earliest effect. A preliminary experiment on the distribution of (methyl- 3 H) choline in a glioblast cell line showed that the increase found in the high affinity uptake of choline might be related to an increase of 3 H incorporation into the phosphorylcholine pool.
- University of California, Irvine United States
Neurons, Time Factors, Ethanol, Biological Transport, Neuroglia, Cells, Cultured, Choline
Neurons, Time Factors, Ethanol, Biological Transport, Neuroglia, Cells, Cultured, Choline
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