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Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndrome

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Dec 1983 Italy Publisher:Elsevier BVJournal:Life Sciences, volume 33, pages 2,651-2,655 (issn: 0024-3205,

Authors: ANNUNZIATO L; AMOROSO S; DI RENZO G; ARGENZIO, Filomena; AURILIO, Caterina; GRELLA, Antonio; QUATTRONE A.;

doi: 10.1016/0024-3205(83)90349-1

pmid: 6664211

handle: 11588/455463 , 11591/231709

Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndrome

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Abstract

In humans the release of growth hormone (GH) elicited by dopamine (DA) and DA agonists may represent a reliable model to assess change in sensitivity of DA receptors. We now report that in chronic alcoholics, 4-7 days after the suspension of alcohol consumption, the increase of GH response to DA infusion was higher than that seen in non alcoholic volunteers. The specificity of this GH response to DA administration was demonstrated by the use of domperidone, a novel peripheral antagonist of DA receptors. These results suggest the development of hyper-responsiveness of DA receptors involved in the control of GH secretion in chronic alcoholics during the later phases of the "withdrawal syndrome".

Country

Italy

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Keywords

Adult, Male, Time Factors, Ethanol, Dopamine, Domperidone, Stimulation, Chemical, Receptors, Dopamine, Substance Withdrawal Syndrome, Growth Hormone, Humans, Female, Adult; Domperidone; Dopamine; Ethanol; Female; Growth Hormone; Humans; Male; Receptors, Dopamine; Stimulation, Chemical; Substance Withdrawal Syndrome; Time Factors

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	25
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average