Attenuation of ethanol intoxication by alpha-2 adrenoceptor antagonists
Copyright policy )Attenuation of ethanol intoxication by alpha-2 adrenoceptor antagonists
The interaction of a highly potent and selective alpha-2 adrenoceptor antagonist, atipamezole with ethanol was investigated in tests assessing a number of ethanol's behavioral effects. Atipamezole antagonized ethanol's effects on directed exploration in a holeboard test, reduced observer-rated intoxication and also reduced the duration of loss of righting reflex caused by ethanol. Similar effects were produced by another alpha-2 adrenoceptor antagonist idazoxan. The magnitude of the effects was comparable to that produced in the same animal models by the imidazodiazepine Ro 15-4513, which antagonizes ethanol by an action at central benzodiazepine receptors. Whereas Ro 15-4513 possesses marked behavioral effects on its own, atipamezole is comparatively inactive in all paradigms so far tested. The data suggest that alpha-2 adrenoceptors can play an important role in modulating the intoxicating effects of ethanol.
- National Institute of Health Pakistan
- National Institutes of Health United States
- National Institute On Alcohol Abuse and Alcoholism United States
- National Institute On Alcohol Abuse and Alcoholism United States
Azides, Behavior, Animal, Ethanol, Imidazoles, Receptors, GABA-A, Dioxanes, Benzodiazepines, Mice, Idazoxan, Seizures, Animals, Alcoholic Intoxication, Adrenergic alpha-Antagonists
Azides, Behavior, Animal, Ethanol, Imidazoles, Receptors, GABA-A, Dioxanes, Benzodiazepines, Mice, Idazoxan, Seizures, Animals, Alcoholic Intoxication, Adrenergic alpha-Antagonists
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