<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Ethanol intake and 3H-serotonin uptake I: A study in fawn-hooded rats

Name: Ethanol intake and 3H-serotonin uptake I: A study in fawn-hooded rats
Keywords: Cerebral Cortex, Male, Analysis of Variance, Serotonin, Ethanol, Body Weight, Hypothalamus, Brain, Rats, Inbred Strains, Hippocampus

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1991Publisher:Elsevier BVJournal:Life Sciences, volume 48, pages 1,969-1,976 (issn: 0024-3205,

Authors: M. Daoust; E. Legrand; P. Boucly; P. Compagnon;

doi: 10.1016/0024-3205(91)90230-9

pmid: 2023528

Ethanol intake and 3H-serotonin uptake I: A study in fawn-hooded rats

- Summary
- Subjects
- Metrics

Abstract

Ethanol intake and synaptosomal 3H-serotonin uptake were studied in male Fawn-Hooded and Sprague-Dawley rats. Fawn-Hooded rats consumed more alcohol and more water than Sprague-Dawley rats. Plasma alcohol levels of Sprague-Dawley rats were not detectable but were about 5 mg/dl in Fawn-Hooded rats. Ethanol intake increased the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex, but not in thalamus. In Fawn-Hooded rats, serotonin uptake (Vmax) was higher than in Sprague-Dawley rats cortex. Ethanol intake reduced the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex. In cortex, the carrier affinity for serotonin was increased in alcoholized Fawn-Hooded rats. These results indicate that synaptosomal 3H-serotonin uptake is affected by ethanol intake. In Fawn-Hooded rats, high ethanol consumption is associated with high serotonin uptake. In rats presenting high serotonin uptake, alcoholisation reduces 3H-serotonin internalisation in synaptosomes, indicating a specific sensitivity to alcohol intake of serotonin uptake system.

Keywords

Cerebral Cortex, Male, Analysis of Variance, Serotonin, Ethanol, Body Weight, Hypothalamus, Brain, Rats, Inbred Strains, Hippocampus, Rats, Mutant Strains, Rats, Animals, Tissue Distribution

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	30
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%