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Ethanol intake and 3H-serotonin uptake I: A study in fawn-hooded rats

pmid: 2023528
Ethanol intake and synaptosomal 3H-serotonin uptake were studied in male Fawn-Hooded and Sprague-Dawley rats. Fawn-Hooded rats consumed more alcohol and more water than Sprague-Dawley rats. Plasma alcohol levels of Sprague-Dawley rats were not detectable but were about 5 mg/dl in Fawn-Hooded rats. Ethanol intake increased the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex, but not in thalamus. In Fawn-Hooded rats, serotonin uptake (Vmax) was higher than in Sprague-Dawley rats cortex. Ethanol intake reduced the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex. In cortex, the carrier affinity for serotonin was increased in alcoholized Fawn-Hooded rats. These results indicate that synaptosomal 3H-serotonin uptake is affected by ethanol intake. In Fawn-Hooded rats, high ethanol consumption is associated with high serotonin uptake. In rats presenting high serotonin uptake, alcoholisation reduces 3H-serotonin internalisation in synaptosomes, indicating a specific sensitivity to alcohol intake of serotonin uptake system.
Cerebral Cortex, Male, Analysis of Variance, Serotonin, Ethanol, Body Weight, Hypothalamus, Brain, Rats, Inbred Strains, Hippocampus, Rats, Mutant Strains, Rats, Animals, Tissue Distribution
Cerebral Cortex, Male, Analysis of Variance, Serotonin, Ethanol, Body Weight, Hypothalamus, Brain, Rats, Inbred Strains, Hippocampus, Rats, Mutant Strains, Rats, Animals, Tissue Distribution
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