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Comparison of the effects of Δ9-tetrahydrocannabinol, 11-hydroxy-Δ9-tetrahydrocannabinol, and ethanol on the electrophysiological activity of the giant axon of the squid

External and intra-axonal application of Δ9-tetrahydrocannabinol was without effect on impulse conduction in the giant axon of the squid whereas 10−8m 11-hydroxy-Δ9-tetrahydrocannabinol reversibly blocked conduction in this preparation. This pharmacological effect of 11-hydroxy-Δ9-tetrahydrocannabinol compares in some respects with that produced by the intra-axonal injection of ethanol into these fibres.
- National Institute of Health Pakistan
- National Center of Neurology and Psychiatry Japan
- National Institute of Mental Health United States
- University of Turin Italy
- National Institutes of Health United States
Time Factors, Ethanol, Decapodiformes, Neural Conduction, In Vitro Techniques, Hydroxylation, Axons, Electric Stimulation, Electrophysiology, Animals, Dronabinol, Cannabinoidi; potenziale d'azione; assone gigante di calamaro, Cannabis
Time Factors, Ethanol, Decapodiformes, Neural Conduction, In Vitro Techniques, Hydroxylation, Axons, Electric Stimulation, Electrophysiology, Animals, Dronabinol, Cannabinoidi; potenziale d'azione; assone gigante di calamaro, Cannabis
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).28 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
