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Pharmacological and metabolic interactions between ethanol and the dopamine-β-hydroxylase inhibitor FLA 63 in mice

Name: Pharmacological and metabolic interactions between ethanol and the dopamine-β-hydroxylase inhibitor FLA 63 in mice
Creator: M. Sharkawi
Keywords: Male, 0301 basic medicine, Ethanol, Imidazoles, Dopamine beta-Hydroxylase, 010402 general chemistry, 01 natural sciences, 3. Good health, 0104 chemical sciences, Alcohol Oxidoreductases

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Mar 1980Publisher:Elsevier BVJournal:Neuropharmacology, volume 19, pages 277-280 (issn: 0028-3908,

Authors: M. Sharkawi;

doi: 10.1016/0028-3908(80)90150-1

pmid: 6999373

Pharmacological and metabolic interactions between ethanol and the dopamine-β-hydroxylase inhibitor FLA 63 in mice

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Abstract

Abstract The duration of ethanol-induced loss of righting reflex was significantly prolonged in mice pretreated with the dopamine-β-hydroxylase inhibitor FLA 63. The disappearance of ethanol from blood, brain, liver and kidneys from FLA 63-treated mice was significantly delayed as compared to control mice. In vitro , FLA 63 inhibited the activity of mouse liver alcohol dehydrogenase. These results demonstrate that FLA 63 can alter the disposition of ethanol. Consequently, its pharmacological activity is altered. The interpretation of results from experiments in which FLA 63 is employed with other drugs should not be based solely on its inhibitory action on dopamine-β-hydroxylase.

Related Organizations

University of Montreal
Canada

Keywords

Male, Ethanol, Imidazoles, Dopamine beta-Hydroxylase, Alcohol Oxidoreductases, Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide, Mice, Liver, Animals, Postural Balance

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