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Neuroscience Letters
Article . 1992 . Peer-reviewed
License: Elsevier TDM
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Neuroscience Letters
Article . 1992
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Repeated ethanol administration decreases prodynorphin biosynthesis in the rat hippocampus

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1992Publisher:Elsevier BVJournal:Neuroscience Letters, volume 134, pages 195-198 (issn: 0304-3940, Copyright policy )
Authors: Barbara Przewlocka; W. Lason; Ryszard Przewlocki;

doi: 10.1016/0304-3940(92)90515-9

pmid: 1589146

Repeated ethanol administration decreases prodynorphin biosynthesis in the rat hippocampus

Abstract

The effect of single and repeated (19 days) intragastric ethanol administration on prodynorphin mRNA and alpha-neoendorphin levels in the hippocampus of the rat was studied using in situ hybridization and RIA methods, respectively. Single ethanol administration had no effect on either of these two parameters. Repeated ethanol administration decreased both immunoreactive (ir) alpha-neoendorphin (by ca. 37%) and prodynorphin mRNA (by ca. 57%) levels. Two days after the last dose of ethanol no changes in the ir-alpha-neoendorphin tissue content were found, whereas the level of prodynorphin mRNA remained decreased (by ca. 44%). These results suggest that repeated ethanol evokes a long-lasting decrease in the biosynthesis of hippocampal prodynorphin, this effect that may play some role in the ethanol-induced deficiency of neuronal functions.

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Keywords

Male, Neurons, Ethanol, Radioimmunoassay, Rats, Inbred Strains, Enkephalins, Sulfur Radioisotopes, Hippocampus, Rats, Alcoholism, Reference Values, Animals, Autoradiography, RNA, Messenger, Protein Precursors, Oligonucleotide Probes

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    		 17
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
17
Average
Average
Average
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