<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://beta.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Prolonged treatment with carbamazepine increases the stimulatory effects of ethanol in mice

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jul 1995Publisher:Elsevier BVJournal:Alcohol, volume 12, pages 305-308 (issn: 0741-8329,

Authors: Maristela Goldnadel Monteiro; Roberto Andreatini; Rosana Camarini;

doi: 10.1016/0741-8329(95)00002-9

pmid: 7546325

Prolonged treatment with carbamazepine increases the stimulatory effects of ethanol in mice

- Summary
- Subjects
- Metrics

Abstract

Carbamazepine (CBZ) has been used in the treatment of alcohol withdrawal (AW). However, cases of induction of euphoric feelings when mixed with alcohol have been reported. We verified whether CBZ could potentiate ethanol stimulatory effects in animals. Two groups of mice were injected with saline (group I) or 2 g/kg ethanol (group II) IP, for 20 days. On the next day, each group was divided into two subgroups that received either a single dose of CBZ (10 mg/kg) or vehicle IP, followed, 30 min later, by saline or ethanol injection. Locomotor activity was measured. Acute CBZ did not change locomotor activity of ethanol-treated mice. Treatment with CBZ or vehicle continued for 6 days. Finally, on the 28th day, 30 min after the last CBZ or vehicle injection, an ethanol challenge was given to group II and a saline injection to group I. The results showed a significant potentiation of ethanol stimulatory effects by chronic CBZ treatment. Data indicated that CBZ should be cautiously administered to alcohol-dependent patients.

Keywords

Male, Analysis of Variance, Time Factors, Ethanol, Drug Synergism, Mice, Inbred Strains, Motor Activity, Stimulation, Chemical, Mice, Carbamazepine, Animals

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	22
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average