In the last years, the growing demand for air conditioning has caused a significant increase in demand for primary energy resources. Solar-powered cooling is one of the technologies which allows to obtain, by using the renewable solar source, an important energy saving compared to traditional air conditioning plants. The paper describes different technical installations for solar cooling, their way of operation, advantages and limits. The objective of the present study has been to analyze the technical and economic feasibility of solar absorption cooling systems, designed for two different application fields: industrial refrigeration and air conditioning. The possibility to replace or integrate the existing plants is studied, by considering the refrigeration requirements of a company, which works in meat manufacturing, and the heating and cooling demands of a hotel located in a tourist town in Italy. In the first case, the system comprises an absorption chiller coupled to solar flat plate collectors, whereas the second application is about a hybrid trigeneration plant, known as thermo-solar trigeneration; this option allows having greater operational flexibility at sites with demand for energy in the form of heating as well as cooling, for example in a hotel. In this way the authors could compare different results obtained by a technical and economic experimental analysis based on existing users and evaluate the advantages and disadvantages in order to suggest the best solution for the two studied cases.