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Brain Research
Article . 2004 . Peer-reviewed
License: Elsevier TDM
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Brain Research
Article . 2004
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Archivio istituzionale della ricerca - Università di Cagliari
Article . 2004
Data sources: Archivio istituzionale della ricerca - Università di Cagliari
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Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 2004 Italy Publisher:Elsevier BVJournal:Brain Research, volume 997, pages 128-132 (issn: 0006-8993, Copyright policy )
Authors: STANCAMPIANO, ROBERTO; CARTA, MANOLO; Cocco S; Curreli R; Rossetti ZL; Fadda F.;

doi: 10.1016/j.brainres.2003.09.078

pmid: 14715158

handle: 11584/94554

Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex

Abstract

Low doses of ethanol (0.5 g/kg i.p.) increased, while higher doses (1 g/kg i.p.) reduced acetylcholine (ACh) release in the rat prefrontal cortex (PFC). Ethanol (50-300 mM) applied in the nucleus basalis through a second dialysis probe caused concentration-dependent biphasic changes in prefrontocortical ACh release. Ethanol apparently acts on cholinergic fibers to modulate ACh transmission in the PFC. These results could be of relevance for the bidirectional modulation of working memory by ethanol.

Country
Italy
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Keywords

Male, Time Factors, Dose-Response Relationship, Drug, Ethanol, Drug Administration Routes, Central Nervous System Depressants, Prefrontal Cortex, Acetylcholine, Rats, Rats, Sprague-Dawley, Animals, Dialysis

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
38
Top 10%
Top 10%
Top 10%
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