Biomass gasification for energy or hydrogen production is a field in continuous evolution, due to the fact that biomass is a renewable and CO2 neutral source. The ability to produce biomass-derived vehicle fuel on a large scale will help to reduce greenhouse gas and pollution, increase the security of European energy supplies, and enhance the use of renewable energy. The Varnamo Biomass Gassification Centre in Sweden is a unique plant and an important site for the development of innovative technologies for biomass transformation. At the moment, the Varnamo plant is the heart of the CHRISGAS European project, that aims to convert the produced gas for further upgrading to liquid fuels as dimethyl ether (DME), methanol or Fischer–Tropsch (F–T) derived diesel. The present work is an attempt to highlight the conditions for the reforming unit and the problems related to working with streams having high contents of sulphur and alkali metals.