At present, water pollution and demand for clean energy are most pressing global issues. On a daily basis, huge quantity of organic wastes gets released into the water ecosystems, causing health related problems. The need-of-the-hour is to utilize proficient and cheaper techniques for complete removal of harmful organic contaminants from water. In this regard, microbial fuel cell (MFC) has emerged as a promising technique, which can produce useful electrical energy from organic wastes and decontaminate polluted water. Herein, we have systematically reviewed recently published results, observations and progress made on the applications of MFCs in degradation of organic contaminants, including organic synthetic dyes, agro pollutants, health care contaminants and other organics (such as phenols and their derivatives, polyhydrocarbons and caffeine). MFC-based hybrid technologies, including MFC-constructed wetland, MFC-photocatalysis, MFC-catalysis, MFC-Fenton process, etc., developed to obtain high removal efficiency and bioelectricity production simultaneously have been discussed. Further, this review assessed the influence of factors, such as nature of electrode catalysts, organic pollutants, electrolyte, microbes and operational conditions, on the performance of pristine and hybrid MFC reactors in terms of pollutant removal efficiency and power generation simultaneously. Moreover, the limitations and future research directions of MFCs for wastewater treatment have been discussed. Finally, a conclusive summary of the findings has been outlined.