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The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Journal 01 Aug 2014Embargo end date: 01 Jan 2014 Switzerland Publisher:Elsevier BVJournal:Clinical Neurophysiology, volume 125, pages 1,700-1,708 (issn: 1388-2457,

Authors: Thomas N. Roth; Stefan C. A. Hegemann; Konrad P. Weber; Sally M. Rosengren; Sally M. Rosengren;

doi: 10.1016/j.clinph.2013.12.096 , 10.5167/uzh-90299

pmid: 24440226

The effect of alcohol on cervical and ocular vestibular evoked myogenic potentials in healthy volunteers

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Abstract

We investigated the effect of alcohol on the cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs). As alcohol produces gaze-evoked nystagmus (GEN), we also tested the effect of nystagmus independent of alcohol by recording oVEMPs during optokinetic stimulation (OKS).The effect of alcohol was tested in 14 subjects over multiple rounds of alcohol consumption up to a maximum breath alcohol concentration (BrAC) of 1.5‰ (mean 0.97‰). The effect of OKS was tested in 11 subjects at 5, 10 and 15deg/sec.oVEMP amplitude decreased from baseline to the highest BrAC level by 27% (range 5-50%, P<0.001), but there was no significant effect on oVEMP latency or cVEMP amplitude or latency. There was a significant negative effect of OKS on oVEMP amplitude (16%, P=0.006).We found a selective effect of alcohol on oVEMP amplitude, but no effect on the cVEMP. Vertical nystagmus elicited by OKS reduced oVEMP amplitude.Alcohol selectively affects oVEMP amplitude. Despite the effects of alcohol and nystagmus, both reflexes were reliably recorded in all subjects and conditions. An absent response in a patient affected by alcohol or nystagmus indicates a vestibular deficit.

Country

Switzerland

Related Organizations

University of Zurich
Switzerland
Royal Prince Alfred Hospital
Australia
Royal Prince Alfred Hospital
Australia
University Hospital of Zurich
Switzerland

Keywords

Adult, Male, Alcohol Drinking, Ethanol, 610 Medicine & health, Vestibular Evoked Myogenic Potentials, Healthy Volunteers, Ophthalmology Clinic, Otolithic Membrane, Young Adult, Breath Tests, Reaction Time, Humans, Female, Vestibule, Labyrinth, Clinic for Otorhinolaryngology, Nystagmus, Optokinetic, Clinic for Neurology

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%