This study is focused on the western part of the French Mediterranean area, namely the Pyre´ne´ es-Orientales and Aude administrative departments. The water resources (surface and groundwater) in the region are sensitive to climate change. The study addresses the question of whether any trend in the annual and monthly series of temperature, rainfall and potential evapotranspiration (PET) already appears at the scale of this region. Two data sources have been used: (a) direct local measurements using the meteorological network; and (b) spatially interpolated data from the French weather service model SAFRAN for the period 1970–2006. The non-parametric Mann–Kendall test was applied to identify significant trends at the local scale and, because of the natural spatial variability of the Mediterranean climate, regional interpretation was also performed. The trends observed in the 13 catchments of interest are consistent with those observed at a larger scale. An increase in annual mean temperature and annual PET was observed throughout the study area, whereas annual precipitation has not exhibited any trend. The monthly scale has revealed strong seasonal variability in trend. The trend for an increase in monthly PET has been observedmainly in the spring, and has not been seen in the coastal areas. A trend for an increase in monthly temperature has been observed in June and in the spring throughout the entire area. Monthly rainfall has been found to decrease in June and increase in November throughout the area. The significant trends observed in rainfall and temperature seem to be consistent between the different data sources.