A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus
Copyright policy )A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus
Mammals, including humans, prepare for sleep by nesting and/or curling up, creating microclimates of skin warmth. To address whether external warmth induces sleep through defined circuitry, we used c-Fos-dependent activity tagging, which captures populations of activated cells and allows them to be reactivated to test their physiological role. External warming tagged two principal groups of neurons in the median preoptic (MnPO)/medial preoptic (MPO) hypothalamic area. GABA neurons located mainly in MPO produced non-rapid eye movement (NREM) sleep but no body temperature decrease. Nitrergic-glutamatergic neurons in MnPO-MPO induced both body cooling and NREM sleep. This circuitry explains how skin warming induces sleep and why the maximal rate of core body cooling positively correlates with sleep onset. Thus, the pathways that promote NREM sleep, reduced energy expenditure, and body cooling are inextricably linked, commanded by the same neurons. This implies that one function of NREM sleep is to lower brain temperature and/or conserve energy.
Current Biology, 28 (14)
ISSN:0960-9822
ISSN:1879-0445
- ETH Zurich Switzerland
- Wellcome Trust United Kingdom
- Wellcome Trust United Kingdom
- University of Zurich Switzerland
- UK Dementia Research Institute United Kingdom
NEURAL CIRCUITRY, Male, Biochemistry & Molecular Biology, Hot Temperature, 610, THERMOSENSORY PATHWAY, ION-CHANNEL, LEPTIN ACTION, TORPOR, anesthesia, Article, MECHANISMS, Mice, 616, PROMOTE, Animals, sleep, TEMPERATURE, 11 Medical and Health Sciences, Neurons, thermoregulation, Science & Technology, Cell Biology, 06 Biological Sciences, energy balance, Adaptation, Physiological, Preoptic Area, 17 Psychology and Cognitive Sciences, RECEPTORS, Cold Temperature, Mice, Inbred C57BL, TetTagging, warm stimulus, sedation, hypothermia, Sleep, Life Sciences & Biomedicine, Proto-Oncogene Proteins c-fos, NOS1, torpor, Developmental Biology, Body Temperature Regulation
NEURAL CIRCUITRY, Male, Biochemistry & Molecular Biology, Hot Temperature, 610, THERMOSENSORY PATHWAY, ION-CHANNEL, LEPTIN ACTION, TORPOR, anesthesia, Article, MECHANISMS, Mice, 616, PROMOTE, Animals, sleep, TEMPERATURE, 11 Medical and Health Sciences, Neurons, thermoregulation, Science & Technology, Cell Biology, 06 Biological Sciences, energy balance, Adaptation, Physiological, Preoptic Area, 17 Psychology and Cognitive Sciences, RECEPTORS, Cold Temperature, Mice, Inbred C57BL, TetTagging, warm stimulus, sedation, hypothermia, Sleep, Life Sciences & Biomedicine, Proto-Oncogene Proteins c-fos, NOS1, torpor, Developmental Biology, Body Temperature Regulation
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