Adsorption cooling systems (ACS) may contribute towards a sustainable way of satisfying the increasing cooling demand, as they utilize solar thermal energy and employ non-ozone-depleting substances. Apart from the intrinsic ACS performance, the successfulness of its operation depends on its integration within the entire thermal system (solar collectors, thermal storage and building), which is not straight-forward due to thermal inertia effects and its inherent cyclic operation. Numerical simulations can contribute in understanding the system behavior, its adequate dimensioning and the implementation of optimized control strategies. A computational model was developed, capable of performing conjugate, dynamic simulations of the entire thermal system. The influence of the control criteria is investigated and quantified through three simulation phases, conducted for various solar collectors areas and storage volumes. Higher solar fraction is achieved for lower auxiliary heater activation temperature and lower temperature difference activation of the solar pump. Subsequently, simulations with variable cycle duration were performed, using optimized cycle duration according to the instantaneous operating temperatures. This approach reduces significantly the auxiliary consumption or satifies the demand with less solar collectors. The potential CO2 emissions avoidance is calculated between 28.1-90.7% with respect to four scenarios of electricity-driven systems of different performance and CO2 emission intensity. Peer Reviewed