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Prevalence of γ-hydroxybutyrate (GHB) in serum samples of amphetamine, metamphetamine and ecstasy impaired drivers

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Dec 2007 Germany Publisher:Elsevier BVJournal:Forensic Science International, volume 173, pages 112-116 (issn: 0379-0738,

Authors: Dresen, Sebastian; Kempf, Jürgen; Weinmann, Wolfgang;

doi: 10.1016/j.forsciint.2007.02.009

pmid: 17383132

Prevalence of γ-hydroxybutyrate (GHB) in serum samples of amphetamine, metamphetamine and ecstasy impaired drivers

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Abstract

Two hundred and forty-seven serum samples which have been collected by police during roadside testing and have been found positive for amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA) and/or 3,4-methylenedioxyethamphetamine (MDE) were analyzed for gamma-hydroxybutyrate (GHB). Serum samples were spiked with deuterated GHB as internal standard and acetonitrile was added to achieve dilution and protein precipitation. Samples were analyzed with a LC-MS/MS system operated in the multiple reaction monitoring mode (MRM) using a TurboIonSpray source. Chromatographic separation was achieved using a Synergi Polar RP column applying a gradient elution with a runtime of 15 min. To differentiate between endogenous and exogenously administered GHB a cut-off concentration of 10 microg/mL was applied. Five samples exceeded this concentration and were found positive for GHB. These samples were only found positive for amphetamine but no other amphetamine derivatives were detected, while in three samples THC and in one sample cocaine, benzoylecgonine and ethanol were found.

Country

Germany

Related Organizations

Instituto Universitario Hospital Italiano
Argentina
Victorian Institute of Forensic Medicine
Australia
University of Freiburg
Germany

Keywords

Adult, Male, Automobile Driving, Adolescent, Amphetamine-Related Disorders, Gas Chromatography-Mass Spectrometry, Forensic Toxicology, Cocaine, Dopamine Uptake Inhibitors, Humans, Ethanol, Amphetamines, Central Nervous System Depressants, Substance Abuse Detection, Female, Sodium Oxybate, Adjuvants, Anesthesia

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