Pollution is a significant problem in both industrialized and developing countries, as well as in some developed countries. Heavy metal pollution poses a crucial concern for communities due to its detrimental impact on human health and the long-term well-being of the planet. Heavy metals, such as cadmium, chromium, arsenic, lead, and mercury, do not degrade and can enter the food chain, leading to significant health risks. Therefore, it is essential to monitor and take necessary steps to eliminate heavy metal residues that may be present in food, beverages, and the environment. Although the exact role of nanomaterials in pollution cleanup is still unclear, nanotechnology holds promise as a future solution. In the first part of this comprehensive review, a brief overview of nanoremediation is provided. The subsequent sections delve into various nanomaterials and their potential applications in different pollution cleanup scenarios. Following that, critical analysis is conducted on different nano-remediation methods, including oxidation, adsorption, chemical precipitation, filtration, ion exchange, coagulation-flocculation, and photo-catalysis. Lastly, further suggestions are put forward regarding the future utilization of nanotechnology for more effective and enduring pollution cleanup, particularly in eliminating heavy metals.