This study developed a method to assess the techno-economic performance and spatial footprint of CO2 capture infrastructure configurations in industrial zones. The method has been successfully applied to a cluster of sixteen industrial plants in the Dutch industrial Botlek area (7.1 MtCO2/y) for 2020–2030. The configurations differ inter alia regarding capture technology (post-, pre-, oxyfuel combustion) and location of capture components (centralized vs. plant site). Results indicate that oxyfuel combustion with centralized oxygen production and decentralized CO2 compression is the most cost effective and realistic configuration when applying CO2 capture to all industrial plants (61€/tCO2; 5.8 MtCO2/y avoided), mainly due to relatively low energy costs compared to post- and pre-combustion. However, oxyfuel combustion at plant level is economically preferable when capturing CO2 from only the three largest industrial plants. For post-combustion, a separated absorber-stripper configuration (73€/tCO2; 7.1 MtCO2/y avoided) is preferable from a cost perspective, due to economic scale effects of capture equipment. The optimal pre-combustion configuration shows a slightly less favorable performance (81€/tCO2; 4.4 MtCO2/y avoided). Whereas many industrial plants have insufficient space available for capture equipment, centralized/hybrid configurations show no insurmountable space issues. The deployment of the most favorable configurations is addressed in Part B.