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Solubility of salbutamol and salbutamol sulphate in ethanol+water mixtures at 25°C

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Sep 2012 United Kingdom Publisher:Elsevier BVJournal:Journal of Molecular Liquids, volume 173, pages 62-65 (issn: 0167-7322,

Authors: Ali, H. S. M.; York, P.; Blagden, Nicholas; Khoubnasabjafari, M.; Acree Jr., W. E.; Jouyban, A.;

doi: 10.1016/j.molliq.2012.05.021

Solubility of salbutamol and salbutamol sulphate in ethanol+water mixtures at 25°C

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Abstract

Experimental solubilities of salbutamol and salbutamol sulphate in ethanol + water mixtures at 25 Â°C are reported. The solubility of salbutamol was found to increase with the addition of ethanol, and reached a maximum value at an ethanol volume fraction of 0.8. The solubility of salbutamol sulphate decreased with increasing ethanol concentration, and reached a minimum value in ethanol. The Jouyban-Acree model correlated the measured salbutamol and salbutamol sulphate solubility data to within mean relative deviations (MRD) of 3.4 and 13.4, respectively. Solubilities were predicted using previously trained models developed for crystalline non-electrolyte and electrolyte solutes. The trained models for non-electrolytes and electrolytes produced the prediction MRDs of 22.4 and 19.8, respectively. Crown Copyright Â© 2012 Published by Elsevier B.V. All rights reserved.

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United Kingdom

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Keywords

570, Ethanol, Salbutamol, Solubility data, Water mixture, F100 - Chemistry, Sulphates, Electrolytes, Maximum values, Minimum value, Solubility, Relative deviations, 617, F100 Chemistry, Jouyban-Acree model, Ethanol concentrations

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