Abstract Forecasting of solar irradiance is in general significant for planning the operations of power plants which convert renewable energies into electricity. In particular, the possibility to predict the solar irradiance (up to 24 h or even more) can became – with reference to the Grid Connected Photovoltaic Plants (GCPV) – fundamental in making power dispatching plans and – with reference to stand alone and hybrid systems – also a useful reference for improving the control algorithms of charge controllers. In this paper, a practical method for solar irradiance forecast using artificial neural network (ANN) is presented. The proposed Multilayer Perceptron MLP-model makes it possible to forecast the solar irradiance on a base of 24 h using the present values of the mean daily solar irradiance and air temperature. An experimental database of solar irradiance and air temperature data (from July 1st 2008 to May 23rd 2009 and from November 23rd 2009 to January 24th 2010) has been used. The database has been collected in Trieste (latitude 45°40′N, longitude 13°46′E), Italy. In order to check the generalization capability of the MLP-forecaster, a K -fold cross-validation was carried out. The results indicate that the proposed model performs well, while the correlation coefficient is in the range 98–99% for sunny days and 94–96% for cloudy days. As an application, the comparison between the forecasted one and the energy produced by the GCPV plant installed on the rooftop of the municipality of Trieste shows the goodness of the proposed model.