In response to the disruptive changes brought upon our society by the COVID-19 pandemic, most work activities and service providers had to resort to remote working. This is credited to reduce emissions for transportation, however the role of forced confinement within dwellings, especially if not designed for hosting working stations, deserves to be properly evaluated in terms of both user acceptance and long-term environmental impact. In this work, a dedicated survey campaign is used for investigating the potential pros and cons of remote working. In more detail, logistic regression and generalized linear models are used for capturing the effect of several independent variables on user acceptance of remote working. At a later stage, the main greenhouse gas emissions produced by each participant before and during remote working are assessed. According to the obtained results, the greater the distance between their home and workplace, the higher the acceptance score declared by the survey participants about remote working. Additionally, higher incomes and better-quality lifestyles with larger devotion to leisure activities also provide higher acceptance. Finally, the existence of a comfortable room to be used for work activities plays a crucial role on the declared acceptance. From an environmental point of view, remote working is always sustainable in case of long commuting distances (above 10 km) are avoided on a daily routine. In conclusion, a sensible use of remote working could reduce the environmental impact of any organization employing desk-workers as well as improve their work satisfaction and lifestyle.