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Cardioprotective effect of chronic low dose ethanol drinking: Insights into the concept of ethanol preconditioning

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Apr 2004 France Publisher:Elsevier BVJournal:Journal of Molecular and Cellular Cardiology, volume 36, pages 561-566 (issn: 0022-2828,

Authors: Guiraud, Annabelle; de Lorgeril, Michel; Boucher, François; Berthonneche, Corinne; Rakotovao, Andry; de Leiris, Joël;

doi: 10.1016/j.yjmcc.2004.02.003

pmid: 15081315

Cardioprotective effect of chronic low dose ethanol drinking: Insights into the concept of ethanol preconditioning

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Abstract

The reason why low-to-moderate alcohol drinking is associated with reduced cardiovascular mortality is not elucidated. While data suggested that ethanol drinking may have a protective effect on global cardiac ischemia, the effect of chronic low dose ethanol drinking (CLEthD) on myocardial infarct size has not been evaluated in a model of regional ischemia. Using an isolated rat heart model to exclude the effect of various in vivo confounders, we have studied the effect of CLEthD on infarct size (IS) and left ventricular function after 30 min of regional ischemia and 120 min of reperfusion. The effect of CLEthD was compared with ischemic preconditioning (IPC) and protein kinase C (PKC) isoforms were analysed in the myocardium before the 30-min ischemia. Ethanol-fed rats received 9% (v/v) ethanol in their drinking water for 7 weeks. Four groups of rats were studied: (1) control, (2) ethanol, (3) control + IPC, (4) ethanol + IPC. Compared with controls (59 +/- 10), IS (as percent of risk zone) was smaller in the ethanol (39 +/- 6) and IPC (31 +/- 8) groups (both p < 0.05). Combination of ethanol and IPC in the same rats further decreased IS (-46% vs. ethanol, p < 0.05). PKC analyses did not show sustained isoform translocation in that model. These data indicate that chronic low dose ethanol drinking actually induces in the rat heart a chronic protective state that is independent from an effect on the traditional (lipid and coagulation) risk factors. Further studies are required to elucidate the mechanisms of that protection.

Country

France

Related Organizations

French Institute for Research in Computer Science and Automation
France
University of Nantes
France
Université de Nantes
France
Joseph Fourier University
France
Grenoble Alpes University
France

Keywords

Perfusion [MESH], Central Nervous System Depressants [MESH], Time Factors, Left, Myocardial Infarction, Myocardial Ischemia, MESH: Protein Isoforms, MESH: Ventricular Function, Left, Ventricular Function, Left, MESH: Ischemic Preconditioning, MESH: Risk Factors, Risk Factors, Protein Isoforms, MESH: Animals, Protein Kinase C, Myocardial Infarction [MESH], Protein Isoforms [MESH], Ethanol [MESH], Heart, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Alcohol Drinking [MESH], Perfusion, MESH: Ischemic Preconditioning, Myocardial, MESH: Myocardial Infarction, Myocardium [MESH], Animals [MESH], Reperfusion Injury, Ischemic Preconditioning, Myocardial, MESH: Myocardial Ischemia, Risk Factors [MESH], MESH: Perfusion, Humans [MESH], MESH: Ethanol, MESH: Myocardium, MESH: Rats, Alcohol Drinking, [SDV.MHEP.CSC] Life Sciences/Human health and pathology/Cardiology and cardiovascular system, 610, Time Factors [MESH], [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, MESH: Ventricular Function, Myocardial, Animals, Humans, Rats [MESH], Heart [MESH], MESH: Humans, Ethanol, Myocardium, MESH: Time Factors, Reperfusion Injury [MESH], Ischemic Preconditioning, Myocardial [MESH], Central Nervous System Depressants, Myocardial Ischemia [MESH], MESH: Protein Kinase C, Rats, MESH: Heart, Ventricular Function, Left [MESH], Protein Kinase C [MESH], MESH: Reperfusion Injury, MESH: Central Nervous System Depressants, MESH: Alcohol Drinking, mesh: mesh:Rats, mesh: mesh:Humans, mesh: mesh:Central Nervous System Depressants, mesh: mesh:Ischemic Preconditioning, Myocardial, mesh: mesh:Protein Isoforms, mesh: mesh:Reperfusion Injury, mesh: mesh:Perfusion, mesh: mesh:Alcohol Drinking, mesh: mesh:Myocardial Infarction, mesh: mesh:Ethanol, mesh: mesh:Risk Factors, mesh: mesh:Myocardium, mesh: mesh:Protein Kinase C, mesh: mesh:Animals, mesh: mesh:Heart, mesh: mesh:Myocardial Ischemia, mesh: mesh:Time Factors, mesh: mesh:Ventricular Function, Left

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