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Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 May 1997Publisher:Elsevier BVJournal:Brain Research, volume 756, pages 278-282 (issn: 0006-8993,

Authors: Gertjan van Dijk; Ilene L. Bernstein; Todd E. Thiele;

doi: 10.1016/s0006-8993(97)00228-x

pmid: 9187343

handle: 11370/06432d7b-4078-48dc-891f-4d6c4100c145

Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption

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Abstract

Selectively bred rat lines, developed to model genetic contributions to alcohol abuse, include the Indiana alcohol-preferring (P) and alcohol-nonpreferring (NP) lines, and the Alko-Alcohol (AA) and Alko-Nonalcohol (ANA) lines. Preferring and nonpreferring lines were compared in their response to intraperitoneal injection of either ethanol or isotonic saline using c-Fos expression as a marker of neuronal activity. Although line differences were noted in several brain regions, the principal finding was that alcohol-nonpreferring lines (NP and ANA) displayed greater c-Fos expression in the locus coeruleus (LC) relative to the alcohol-preferring lines (P and AA) following injection of 3.0 g ethanol/kg. These data point to the LC as an area which may play a role in the differences in voluntary ethanol consumption between rat lines genetically bred for low and high ethanol preference.

Related Organizations

University of Mary
United States
Washington State University
United States

Keywords

Male, c-Fos, Selected line, Alcohol Drinking, Ethanol, Brain, Rats, Inbred Strains, Sodium Chloride, Rats, Locus coeruleus, Genetics, Nucleus accumbens, Animals, Locus Coeruleus, Tissue Distribution, Isotonic Solutions, Selection, Genetic, Proto-Oncogene Proteins c-fos, Injections, Intraperitoneal

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