GABAA–benzodiazepine receptor complex sensitivity in 5-HT1A receptor knockout mice on a 129/Sv background
Copyright policy )GABAA–benzodiazepine receptor complex sensitivity in 5-HT1A receptor knockout mice on a 129/Sv background
Previous studies in 5-HT(1A) receptor knockout (1AKO) mice on a mixed Swiss Websterx129/Sv (SWx129/Sv) and a pure 129/Sv genetic background suggest a differential gamma-aminobutyric acid (GABA(A))-benzodiazepine receptor complex sensitivity in both strains, independent from the anxious phenotype. To further investigate these discrepancies, various GABA(A)-benzodiazepine receptor ligands were tested in different behavioral paradigms in 1AKO and wild type (WT) mice on a 129/Sv background. 1AKO and WT mice responded comparably to alprazolam, flumazenil, alcohol and pentylenetetrazol as measured in the stress-induced hyperthermia paradigm. In addition, sedative-anesthetic effects of pentobarbital measured via the righting reflex were similar and a selected dose of diazepam exerted similar anxiolytic effects in both genotypes in the elevated plus maze. In conclusion, 1AKO mice on a 129/Sv background have undisturbed GABA(A)-benzodiazepine receptor sensitivity in contrast to those described on a mixed Swiss Websterx129/Sv background. The anxious phenotype of 1AKO mice seems to occur independent of the GABA(A)-benzodiazepine receptor complex functioning.
- Radboud University Nijmegen Netherlands
- Yale University United States
- Amsterdam UMC, location VUmc Netherlands
- Utrecht University Netherlands
Flumazenil, Male, Psychopharmacology, genotype, drug response, Farmacotherapie van psychomotorische ziektebeelden; fundamenteel en toegepast onderzoek, tranquilizing activity, Biomedische technologie en medicijnen, ligand, animal behavior, Biochemistry, righting reflex, Pentylenetetrazol, Farmacie/Biofarmaceutische wetenschappen (FARM), GABA Antagonists, alprazolam, stress, Mice, Hypnotics and Sedatives, strain difference, 4 aminobutyric acid A receptor, Mice, Knockout, alcohol, drug receptor binding, Farmacie(FARM), article, anxiety, hyperthermia, Positive righting reflex, (In vivo), priority journal, sedation, Phenobarbital, 5-HT1A receptor knockout mice, GABAA-benzodiazepine receptor, mouse strain, wild type, serotonin 1A receptor, Drugmisbruik en verslaving, Fever, phenotype, animal experiment, pentetrazole, anesthesia, male, Species Specificity, benzodiazepine receptor, Reflex, Genetics, flumazenil, Animals, controlled study, maze test, Maze Learning, pentobarbital, diazepam, Pharmacology, nonhuman, Diazepam, Alprazolam, Ethanol, animal model, receptor sensitivity, Pharmacotherapy of psychomotor diseases; fundamental and applied research, Receptors, GABA-A, Stress-induced hyperthermia, Anti-Anxiety Agents, Receptors, Serotonin, Pentylenetetrazole, knockout mouse, Analytical chemistry, Receptors, Serotonin, 5-HT1
Flumazenil, Male, Psychopharmacology, genotype, drug response, Farmacotherapie van psychomotorische ziektebeelden; fundamenteel en toegepast onderzoek, tranquilizing activity, Biomedische technologie en medicijnen, ligand, animal behavior, Biochemistry, righting reflex, Pentylenetetrazol, Farmacie/Biofarmaceutische wetenschappen (FARM), GABA Antagonists, alprazolam, stress, Mice, Hypnotics and Sedatives, strain difference, 4 aminobutyric acid A receptor, Mice, Knockout, alcohol, drug receptor binding, Farmacie(FARM), article, anxiety, hyperthermia, Positive righting reflex, (In vivo), priority journal, sedation, Phenobarbital, 5-HT1A receptor knockout mice, GABAA-benzodiazepine receptor, mouse strain, wild type, serotonin 1A receptor, Drugmisbruik en verslaving, Fever, phenotype, animal experiment, pentetrazole, anesthesia, male, Species Specificity, benzodiazepine receptor, Reflex, Genetics, flumazenil, Animals, controlled study, maze test, Maze Learning, pentobarbital, diazepam, Pharmacology, nonhuman, Diazepam, Alprazolam, Ethanol, animal model, receptor sensitivity, Pharmacotherapy of psychomotor diseases; fundamental and applied research, Receptors, GABA-A, Stress-induced hyperthermia, Anti-Anxiety Agents, Receptors, Serotonin, Pentylenetetrazole, knockout mouse, Analytical chemistry, Receptors, Serotonin, 5-HT1
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