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Electrophoretic behavior of alprenolol in mixed solvent electrolyte systems

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Oct 2003Publisher:Elsevier BVJournal:Il Farmaco, volume 58, pages 1,039-1,044 (issn: 0014-827X,

Authors: Abolghasem Jouyban; S. Yeghanli; Brian J. Clark; Maryam Khoubnasabjafari; S.C. Grosse;

doi: 10.1016/s0014-827x(03)00177-0

pmid: 14505736

Electrophoretic behavior of alprenolol in mixed solvent electrolyte systems

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Abstract

The electrophoretic mobilities of alprenolol have been determined in a mixed solvent background electrolyte system containing sodium acetate (40 mM)+acetic acid (40 mM) as buffering agent and different volume fractions of water, methanol and ethanol using capillary electrophoresis. The mobility of alprenolol has been used to test the prediction capability of a model trained by previously reported mobility data of five beta-blocker drugs at the same electrophoretic conditions. The average percentage mean deviations (APMD) between experimental and predicted values were used as an accuracy criterion. The APMD (+/-SD) obtained for alprenolol data in binary/ternary solvent electrolyte system employing the mobility values in mono-solvent buffers was 4.37 (+/-3.50)% and the corresponding value for an ab initio prediction method was 7.65 (+/-4.30)%.

Related Organizations

Tabriz University of Medical Sciences
Iran (Islamic Republic of)
Tabriz University of Medical Sciences
Iran (Islamic Republic of)
University of Bradford
United Kingdom
University of Bradford
United Kingdom

Keywords

Ethanol, Methanol, Adrenergic beta-Antagonists, Electrophoresis, Capillary, Water, Buffers, Electrolytes, Predictive Value of Tests, Solvents, Alprenolol

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