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PHARMACOLOGICAL BLOCKADE OF CARCINOID FLUSHING PROVOKED BY CATECHOLAMINES AND ALCOHOL

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Aug 1969Publisher:Elsevier BVJournal:The Lancet, volume 294, pages 293-297 (issn: 0140-6736,

Authors: D.G. Grahame-Smith; W.S. Peart; M. Starr; A.R. Adamson;

doi: 10.1016/s0140-6736(69)90056-7 , 10.1016/s0140-6736(69)90295-5 , 10.1016/0002-8703(71)90064-0

pmid: 4185558 , 4184213 , 5539992

PHARMACOLOGICAL BLOCKADE OF CARCINOID FLUSHING PROVOKED BY CATECHOLAMINES AND ALCOHOL

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Abstract

Abstract In patients with the carcinoid syndrome flushing provoked by intravenous noradrenaline, adrenaline, and dopamine, and by oral alcohol, was accompanied by a rise in bradykinin concentration in arterial blood. Flushing provoked by the catecholamines was blocked by intravenous phentolamine which simultaneously inhibited the rise in bradykinin concentration. Intravenous phentolamine in high doses also blocked flushing provoked by alcohol. The time sequence of alcohol-induced flushing and the inhibition of this flushing by α-adrenergic blockade suggests that alcohol might release a catecholamine which acts upon the tumour cell to release kallikrein.

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Keywords

Adult, Male, Epinephrine, Dopamine, Hyperemia, Carcinoid Tumor, Bradykinin, Norepinephrine, Catecholamines, Skin Manifestations, Methods, Humans, Phentolamine, Aged, Malignant Carcinoid Syndrome, Phenoxybenzamine, Ethanol, Respiration, Middle Aged, Chemoreceptor Cells, Injections, Intravenous, Female, Kallikreins

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