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G2-chromosome aberrations induced by high-let radiations

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 2001Publisher:Elsevier BVJournal:Advances in Space Research, volume 27, pages 383-391 (issn: 0273-1177,

Authors: Kerry George; Yoshiya Furusawa; Hisao Ito; Honglu Wu; Francesca A Cucinotta; Tetsuya Kawata; Marco Durante;

doi: 10.1016/s0273-1177(01)00006-0

pmid: 11642300

G2-chromosome aberrations induced by high-let radiations

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Abstract

We report measurement of initial G2-chromatid breaks in normal human fibroblasts exposed to various types of high-LET particles. Exponentially growing AG 1522 cells were exposed to gamma rays or heavy ions. Chromosomes were prematurely condensed by calyculin A. Chromatid-type breaks and isochromatid-type breaks were scored separately. The dose response curves for the induction of total chromatid breaks (chromatid-type + isochromatid-type) and chromatid-type breaks were linear for each type of radiation. However, dose response curves for the induction of isochromatid-type breaks were linear for high-LET radiations and linear-quadratic for gamma rays. Relative biological effectiveness (RBE), calculated from total breaks, showed a LET dependent tendency with a peak at 55 keV/micrometer silicon (2.7) or 80 keV/micrometer carbon (2.7) and then decreased with LET (1.5 at 440 keV/micrometer). RBE for chromatid-type break peaked at 55 keV/micrometer (2.4) then decreased rapidly with LET. The RBE of 440 keV/micrometer iron particles was 0.7. The RBE calculated from induction of isochromatid-type breaks was much higher for high-LET radiations. It is concluded that the increased production of isochromatid-type breaks, induced by the densely ionizing track structure, is a signature of high-LET radiation exposure.

Related Organizations

National Aeronautics and Space Administration
United States
Radiation Biophysics Laboratory
United States
Chiba University
Japan
Kelsey-Seybold Clinic
United States
Universities Space Research Association
United States

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Keywords

Chromosome Aberrations, G2 Phase, Dose-Response Relationship, Radiation, Chromatids, Fibroblasts, Chromosomes, Cell Line, Gamma Rays, Phosphoprotein Phosphatases, Humans, Heavy Ions, Linear Energy Transfer, Marine Toxins, Enzyme Inhibitors, Oxazoles, Cells, Cultured, Relative Biological Effectiveness, DNA Damage

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